LymphedemaV1, Main, Merge, bibRecord, 004C26

Recombinant Wolbachia surface protein (WSP)-induced T cell responses in Wuchereria bancrofti infections

Identifieur interne : 004C26 ( Main/Merge ); précédent : 004C25; suivant : 004C27

Recombinant Wolbachia surface protein (WSP)-induced T cell responses in Wuchereria bancrofti infections

Auteurs : C. Shiny ; N. S. A. Krushna ; K. Haripriya ; S. Babu ; S. Elango ; G. Manokaran ; R. B. Narayanan

Source :

Parasitology research [ 0932-0113 ] ; 2011.

RBID : PMC:3518551

Descripteurs français

English descriptors

KwdEn :
- Animals, Antigens, CD (analysis), Antigens, Differentiation, T-Lymphocyte (analysis), Bacterial Outer Membrane Proteins (immunology), CTLA-4 Antigen (analysis), Cell Proliferation, Cytokines (secretion), Elephantiasis, Filarial (immunology), Humans, Interleukin-2 Receptor alpha Subunit (analysis), Interleukin-7 Receptor alpha Subunit (analysis), L-Selectin (analysis), Lectins, C-Type (analysis), Leukocytes, Mononuclear (chemistry), Leukocytes, Mononuclear (immunology), Membrane Proteins (immunology), T-Lymphocytes (chemistry), T-Lymphocytes (immunology), T-Lymphocytes, Regulatory (chemistry), T-Lymphocytes, Regulatory (immunology), Wolbachia (immunology), Wuchereria bancrofti (microbiology), Wuchereria bancrofti (pathogenicity).
MESH :
- chemical , analysis : Antigens, CD, Antigens, Differentiation, T-Lymphocyte, CTLA-4 Antigen, Interleukin-2 Receptor alpha Subunit, Interleukin-7 Receptor alpha Subunit, L-Selectin, Lectins, C-Type.
- chemical , immunology : Bacterial Outer Membrane Proteins, Membrane Proteins.
- chemical , secretion : Cytokines.
- chemistry : Leukocytes, Mononuclear, T-Lymphocytes, T-Lymphocytes, Regulatory.
- immunology : Elephantiasis, Filarial, Leukocytes, Mononuclear, T-Lymphocytes, T-Lymphocytes, Regulatory, Wolbachia.
- microbiology : Wuchereria bancrofti.
- pathogenicity : Wuchereria bancrofti.
- Animals, Cell Proliferation, Humans.

Abstract

Human lymphatic filariasis is a debilitating parasitic disease characterized by downregulation of the host’s immune response in asymptomatic carriers along with profound hyperreactivity in chronic patients apart from putatively immune endemic normals. The endosymbiont Wolbachia, a bacterium of filarial nematodes has received much attention as possible chemotherapeutic target and its involvement in disease pathogenesis. The role of recombinant Wolbachia surface protein (rWSP), one of the most abundantly expressed proteins of the endosymbiont, in modulating cell-mediated immune responses in patients harboring Wuchereria bancrofti infections was evaluated in the current study. rWSP-induced lymphoproliferation with peripheral blood mononuclear cells suggested an impaired proliferative response in asymptomatic microfilaremic (MF) and symptomatic chronic pathology (CP) patients compared to endemic normals (EN). This was further supported by a significantly diminished expression of CD69 along with elevated levels of CD127 and CD62L in filarial patients (MF and CP) compared to EN. Further, rWSP induced the expression of regulatory T cell markers CTLA-4 and CD25 along with suppressor cytokines IL-10 and TGF-β in MF and CP patients compared to EN. However, the rWSP-stimulated expression of IFN-γ was diminished significantly in filarial patients compared to endemic normals. Thus, these findings suggest that WSP may also contribute to the suppression of immune responses seen in filarial patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518551

DOI: 10.1007/s00436-011-2553-7
PubMed: 21786068
PubMed Central: 3518551

Links to Exploration step

PMC:3518551

Le document en format XML

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 infections</title>
<author><name sortKey="Shiny, C" sort="Shiny, C" uniqKey="Shiny C" first="C." last="Shiny">C. Shiny</name>
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<author><name sortKey="Krushna, N S A" sort="Krushna, N S A" uniqKey="Krushna N" first="N. S. A." last="Krushna">N. S. A. Krushna</name>
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<series><title level="j">Parasitology research</title>
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<term>Antigens, Differentiation, T-Lymphocyte (analysis)</term>
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<term>CTLA-4 Antigen (analysis)</term>
<term>Cell Proliferation</term>
<term>Cytokines (secretion)</term>
<term>Elephantiasis, Filarial (immunology)</term>
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<term>Interleukin-2 Receptor alpha Subunit (analysis)</term>
<term>Interleukin-7 Receptor alpha Subunit (analysis)</term>
<term>L-Selectin (analysis)</term>
<term>Lectins, C-Type (analysis)</term>
<term>Leukocytes, Mononuclear (chemistry)</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Membrane Proteins (immunology)</term>
<term>T-Lymphocytes (chemistry)</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes, Regulatory (chemistry)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>Wolbachia (immunology)</term>
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<term>Animaux</term>
<term>Antigène CTLA-4 (analyse)</term>
<term>Antigènes CD (analyse)</term>
<term>Antigènes de différenciation des lymphocytes T (analyse)</term>
<term>Cytokines (sécrétion)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Humains</term>
<term>Lectines de type C (analyse)</term>
<term>Lymphocytes T ()</term>
<term>Lymphocytes T (immunologie)</term>
<term>Lymphocytes T régulateurs ()</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Prolifération cellulaire</term>
<term>Protéines de la membrane externe bactérienne (immunologie)</term>
<term>Protéines membranaires (immunologie)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (analyse)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-7 (analyse)</term>
<term>Sélectine L (analyse)</term>
<term>Wolbachia (immunologie)</term>
<term>Wuchereria bancrofti (microbiologie)</term>
<term>Wuchereria bancrofti (pathogénicité)</term>
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<term>Antigens, Differentiation, T-Lymphocyte</term>
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<term>Interleukin-2 Receptor alpha Subunit</term>
<term>Interleukin-7 Receptor alpha Subunit</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Human lymphatic filariasis is a debilitating parasitic disease characterized by downregulation of the host’s immune response in asymptomatic carriers along with profound hyperreactivity in chronic patients apart from putatively immune endemic normals. The endosymbiont <italic>Wolbachia</italic>
, a bacterium of filarial nematodes has received much attention as possible chemotherapeutic target and its involvement in disease pathogenesis. The role of recombinant <italic>Wolbachia</italic>
 surface protein (rWSP), one of the most abundantly expressed proteins of the endosymbiont, in modulating cell-mediated immune responses in patients harboring <italic>Wuchereria bancrofti</italic>
 infections was evaluated in the current study. rWSP-induced lymphoproliferation with peripheral blood mononuclear cells suggested an impaired proliferative response in asymptomatic microfilaremic (MF) and symptomatic chronic pathology (CP) patients compared to endemic normals (EN). This was further supported by a significantly diminished expression of CD69 along with elevated levels of CD127 and CD62L in filarial patients (MF and CP) compared to EN. Further, rWSP induced the expression of regulatory T cell markers CTLA-4 and CD25 along with suppressor cytokines IL-10 and TGF-β in MF and CP patients compared to EN. However, the rWSP-stimulated expression of IFN-γ was diminished significantly in filarial patients compared to endemic normals. Thus, these findings suggest that WSP may also contribute to the suppression of immune responses seen in filarial patients.</p>
</div>
</front>
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Serveur d'exploration sur le lymphœdème

Recombinant Wolbachia surface protein (WSP)-induced T cell responses in Wuchereria bancrofti infections

Recombinant Wolbachia surface protein (WSP)-induced T cell responses in Wuchereria bancrofti infections

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

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