Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system
Identifieur interne : 004472 ( Main/Merge ); précédent : 004471; suivant : 004473Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system
Auteurs : W. L. Olszewski [Pologne] ; P. Jain [Inde] ; M. Zaleska [Pologne] ; E. Stelmach [Pologne] ; E. Swoboda [Pologne]Source :
- Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India [ 0970-0358 ] ; 2012.
Abstract
Wound healing should not be considered as a process limited only to the damaged tissues. It is always accompanied by an intensive local immune response and in advanced stages, the systemic lymphatic (immune) structure. In this review we present evidence from our own studies as well as pertinent literature on the role of skin and subcutaneous tissue lymphatics at the wound site and of transport of antigens along with collecting afferent lymphatics to the lymph nodes. We also speculate the role of lymph nodes in raising cohorts of bacterial and own tissue antigen-specific lymphocytes and their participation in healing and not infrequently evoking uncontrolled chronic immune reaction causing a delay of healing. It is also speculated as to why there is a rapid response of lymph node cells to microbial antigens and tolerance to damaged-tissue-derived antigens occurs
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DOI: 10.4103/0970-0358.101289
PubMed: 23162224
PubMed Central: 3495375
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L." last="Olszewski">W. L. Olszewski</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Central Clinical Hospital, Warsaw Medical University, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Central Clinical Hospital, Warsaw Medical University, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Jain, P" sort="Jain, P" uniqKey="Jain P" first="P." last="Jain">P. 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Olszewski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szczesny, G" uniqKey="Szczesny G">G Szczesny</name></author><author><name sortKey="Olszewski, Wl" uniqKey="Olszewski W">WL Olszewski</name></author><author><name sortKey="Zaleska, M" uniqKey="Zaleska M">M Zaleska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szczesny, G" uniqKey="Szczesny G">G Szczesny</name></author><author><name sortKey="Olszewski, Wl" uniqKey="Olszewski W">WL Olszewski</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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