The mouse lymph node as an ectopic transplantation site for multiple tissues
Identifieur interne : 003E18 ( Main/Merge ); précédent : 003E17; suivant : 003E19The mouse lymph node as an ectopic transplantation site for multiple tissues
Auteurs : Junji Komori ; Lindsey Boone ; Aaron Deward ; Toshitaka Hoppo ; Eric LagasseSource :
- Nature biotechnology [ 1087-0156 ] ; 2012.
Abstract
Cell-based therapy has been viewed as a promising alternative to organ transplantation, but cell transplantation aimed at organ repair is not always possible. Here, we show that the mouse lymph node can support the engraftment and growth of healthy cells from multiple tissues. Direct injection of hepatocytes into a single mouse lymph node generated enough ectopic liver mass to rescue survival of mice with lethal metabolic disease. Furthermore, thymuses transplanted into a lymph node of athymic nude mice generate a functional immune system capable of rejecting allogeneic and xenogeneic grafts. Finally, pancreatic islets injected into the lymph node of diabetic mice restore normal glucose control. Collectively, these results suggest the practical approach of targeting lymph nodes to restore, maintain or improve tissue and organ functions.
Url:
DOI: 10.1038/nbt.2379
PubMed: 23000933
PubMed Central: 3469750
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code="subfield">Pittsburgh PA</wicri:noCountry></affiliation></author><author><name sortKey="Deward, Aaron" sort="Deward, Aaron" uniqKey="Deward A" first="Aaron" last="Deward">Aaron Deward</name><affiliation><nlm:aff id="A1">McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh PA</nlm:aff><wicri:noCountry code="subfield">Pittsburgh PA</wicri:noCountry></affiliation></author><author><name sortKey="Hoppo, Toshitaka" sort="Hoppo, Toshitaka" uniqKey="Hoppo T" first="Toshitaka" last="Hoppo">Toshitaka Hoppo</name><affiliation><nlm:aff id="A1">McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh PA</nlm:aff><wicri:noCountry code="subfield">Pittsburgh PA</wicri:noCountry></affiliation></author><author><name sortKey="Lagasse, Eric" sort="Lagasse, Eric" uniqKey="Lagasse E" first="Eric" last="Lagasse">Eric Lagasse</name><affiliation><nlm:aff id="A1">McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh PA</nlm:aff><wicri:noCountry code="subfield">Pittsburgh PA</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature biotechnology</title><idno type="ISSN">1087-0156</idno><idno type="eISSN">1546-1696</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cell-based therapy has been viewed as a promising alternative to organ transplantation, but cell transplantation aimed at organ repair is not always possible. Here, we show that the mouse lymph node can support the engraftment and growth of healthy cells from multiple tissues. Direct injection of hepatocytes into a single mouse lymph node generated enough ectopic liver mass to rescue survival of mice with lethal metabolic disease. Furthermore, thymuses transplanted into a lymph node of athymic nude mice generate a functional immune system capable of rejecting allogeneic and xenogeneic grafts. Finally, pancreatic islets injected into the lymph node of diabetic mice restore normal glucose control. Collectively, these results suggest the practical approach of targeting lymph nodes to restore, maintain or improve tissue and organ functions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fisher, Ra" uniqKey="Fisher R">RA Fisher</name></author><author><name sortKey="Strom, Sc" uniqKey="Strom S">SC Strom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapiro, Am" uniqKey="Shapiro A">AM Shapiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuppan, D" uniqKey="Schuppan D">D Schuppan</name></author><author><name sortKey="Afdhal, Nh" uniqKey="Afdhal N">NH Afdhal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markert, Ml" uniqKey="Markert M">ML Markert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markert, Ml" uniqKey="Markert M">ML Markert</name></author><author><name 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