Expression of Angiopoietin-TIE System Components in Angiosarcoma
Identifieur interne : 003655 ( Main/Merge ); précédent : 003654; suivant : 003656Expression of Angiopoietin-TIE System Components in Angiosarcoma
Auteurs : Darya Buehler [États-Unis] ; Patrick Rush [États-Unis] ; Jason R. Hasenstein [États-Unis] ; Stephanie R. Rice [États-Unis] ; Gholam Reza Hafez [États-Unis] ; B. Jack Longley [États-Unis] ; Kevin R. Kozak [États-Unis]Source :
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [ 0893-3952 ] ; 2013.
Abstract
Angiosarcoma is an aggressive malignancy of endothelial differentiation. Potential roles of the endothelial angiopoietin-tunica internal endothelial cell kinase (ANGPT-TIE) system in angiosarcoma diagnosis, pathogenesis, prognosis and treatment are undefined. To examine the expression and prognostic significance of angiopoietin-1, angiopoietin-2, TIE1 and TEK (TIE2) proteins in angiosarcoma, we immunohistochemically evaluated clinically annotated human angiosarcoma samples. Correlations of protein expression with overall survival and pathologic features were explored. The cohort included 51 patients diagnosed with angiosarcoma at age 30-86 years old (median 67). The 5-year overall survival was 45% with a median of 26 months. Moderate to strong expression of angiopoietin-1, TIE1 and TEK (TIE2) was identified in the majority of angiosarcomas and moderate to strong expression of angiopoietin-2 was observed in 42% of angiosarcomas. Increased angiopoietin-1 expression correlated with improved survival. Non-significant trends toward longer survival were also observed with increased TIE1 and TEK (TIE2) expression. Increased expression of angiopoietin-2, TIE1 and TEK (TIE2) was associated with vasoformative architecture. No differences in expression of these proteins were observed when patients were segregated by age, gender, presence or absence of metastases at diagnosis, primary tumor location, radiation association or the presence of necrosis. We conclude that components of the ANGPT-TIE system are commonly expressed in angiosarcomas. Reduced expression of these proteins is associated with non-vasoformative and clinically more aggressive lesions.
Url:
DOI: 10.1038/modpathol.2013.43
PubMed: 23558570
PubMed Central: 3706492
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004706
- to stream Pmc, to step Curation: 004705
- to stream Pmc, to step Checkpoint: 002339
- to stream Ncbi, to step Merge: 005798
- to stream Ncbi, to step Curation: 005798
- to stream Ncbi, to step Checkpoint: 005798
Links to Exploration step
PMC:3706492Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expression of Angiopoietin-TIE System Components in Angiosarcoma</title>
<author><name sortKey="Buehler, Darya" sort="Buehler, Darya" uniqKey="Buehler D" first="Darya" last="Buehler">Darya Buehler</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rush, Patrick" sort="Rush, Patrick" uniqKey="Rush P" first="Patrick" last="Rush">Patrick Rush</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hasenstein, Jason R" sort="Hasenstein, Jason R" uniqKey="Hasenstein J" first="Jason R." last="Hasenstein">Jason R. Hasenstein</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rice, Stephanie R" sort="Rice, Stephanie R" uniqKey="Rice S" first="Stephanie R." last="Rice">Stephanie R. Rice</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hafez, Gholam Reza" sort="Hafez, Gholam Reza" uniqKey="Hafez G" first="Gholam Reza" last="Hafez">Gholam Reza Hafez</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Longley, B Jack" sort="Longley, B Jack" uniqKey="Longley B" first="B. Jack" last="Longley">B. Jack Longley</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kozak, Kevin R" sort="Kozak, Kevin R" uniqKey="Kozak K" first="Kevin R" last="Kozak">Kevin R. Kozak</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23558570</idno>
<idno type="pmc">3706492</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706492</idno>
<idno type="RBID">PMC:3706492</idno>
<idno type="doi">10.1038/modpathol.2013.43</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">004706</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004706</idno>
<idno type="wicri:Area/Pmc/Curation">004705</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004705</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002339</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002339</idno>
<idno type="wicri:Area/Ncbi/Merge">005798</idno>
<idno type="wicri:Area/Ncbi/Curation">005798</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005798</idno>
<idno type="wicri:doubleKey">0893-3952:2013:Buehler D:expression:of:angiopoietin</idno>
<idno type="wicri:Area/Main/Merge">003655</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Expression of Angiopoietin-TIE System Components in Angiosarcoma</title>
<author><name sortKey="Buehler, Darya" sort="Buehler, Darya" uniqKey="Buehler D" first="Darya" last="Buehler">Darya Buehler</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rush, Patrick" sort="Rush, Patrick" uniqKey="Rush P" first="Patrick" last="Rush">Patrick Rush</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hasenstein, Jason R" sort="Hasenstein, Jason R" uniqKey="Hasenstein J" first="Jason R." last="Hasenstein">Jason R. Hasenstein</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rice, Stephanie R" sort="Rice, Stephanie R" uniqKey="Rice S" first="Stephanie R." last="Rice">Stephanie R. Rice</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hafez, Gholam Reza" sort="Hafez, Gholam Reza" uniqKey="Hafez G" first="Gholam Reza" last="Hafez">Gholam Reza Hafez</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Longley, B Jack" sort="Longley, B Jack" uniqKey="Longley B" first="B. Jack" last="Longley">B. Jack Longley</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kozak, Kevin R" sort="Kozak, Kevin R" uniqKey="Kozak K" first="Kevin R" last="Kozak">Kevin R. Kozak</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc</title>
<idno type="ISSN">0893-3952</idno>
<idno type="eISSN">1530-0285</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Angiosarcoma is an aggressive malignancy of endothelial differentiation. Potential roles of the endothelial angiopoietin-tunica internal endothelial cell kinase (ANGPT-TIE) system in angiosarcoma diagnosis, pathogenesis, prognosis and treatment are undefined. To examine the expression and prognostic significance of angiopoietin-1, angiopoietin-2, TIE1 and TEK (TIE2) proteins in angiosarcoma, we immunohistochemically evaluated clinically annotated human angiosarcoma samples. Correlations of protein expression with overall survival and pathologic features were explored. The cohort included 51 patients diagnosed with angiosarcoma at age 30-86 years old (median 67). The 5-year overall survival was 45% with a median of 26 months. Moderate to strong expression of angiopoietin-1, TIE1 and TEK (TIE2) was identified in the majority of angiosarcomas and moderate to strong expression of angiopoietin-2 was observed in 42% of angiosarcomas. Increased angiopoietin-1 expression correlated with improved survival. Non-significant trends toward longer survival were also observed with increased TIE1 and TEK (TIE2) expression. Increased expression of angiopoietin-2, TIE1 and TEK (TIE2) was associated with vasoformative architecture. No differences in expression of these proteins were observed when patients were segregated by age, gender, presence or absence of metastases at diagnosis, primary tumor location, radiation association or the presence of necrosis. We conclude that components of the ANGPT-TIE system are commonly expressed in angiosarcomas. Reduced expression of these proteins is associated with non-vasoformative and clinically more aggressive lesions.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abraham, Ja" uniqKey="Abraham J">JA Abraham</name>
</author>
<author><name sortKey="Hornicek, Fj" uniqKey="Hornicek F">FJ Hornicek</name>
</author>
<author><name sortKey="Kaufman, Am" uniqKey="Kaufman A">AM Kaufman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fayette, J" uniqKey="Fayette J">J Fayette</name>
</author>
<author><name sortKey="Martin, E" uniqKey="Martin E">E Martin</name>
</author>
<author><name sortKey="Piperno Neumann, S" uniqKey="Piperno Neumann S">S Piperno-Neumann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fury, Mg" uniqKey="Fury M">MG Fury</name>
</author>
<author><name sortKey="Antonescu, Cr" uniqKey="Antonescu C">CR Antonescu</name>
</author>
<author><name sortKey="Van Zee, Kj" uniqKey="Van Zee K">KJ Van Zee</name>
</author>
<author><name sortKey="Brennan, Mf" uniqKey="Brennan M">MF Brennan</name>
</author>
<author><name sortKey="Maki, Rg" uniqKey="Maki R">RG Maki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mark, Rj" uniqKey="Mark R">RJ Mark</name>
</author>
<author><name sortKey="Poen, Jc" uniqKey="Poen J">JC Poen</name>
</author>
<author><name sortKey="Tran, Lm" uniqKey="Tran L">LM Tran</name>
</author>
<author><name sortKey="Fu, Ys" uniqKey="Fu Y">YS Fu</name>
</author>
<author><name sortKey="Juillard, Gf" uniqKey="Juillard G">GF Juillard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naka, N" uniqKey="Naka N">N Naka</name>
</author>
<author><name sortKey="Ohsawa, M" uniqKey="Ohsawa M">M Ohsawa</name>
</author>
<author><name sortKey="Tomita, Y" uniqKey="Tomita Y">Y Tomita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Penel, N" uniqKey="Penel N">N Penel</name>
</author>
<author><name sortKey="Marreaud, S" uniqKey="Marreaud S">S Marreaud</name>
</author>
<author><name sortKey="Robin, Ym" uniqKey="Robin Y">YM Robin</name>
</author>
<author><name sortKey="Hohenberger, P" uniqKey="Hohenberger P">P Hohenberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brown, Lf" uniqKey="Brown L">LF Brown</name>
</author>
<author><name sortKey="Tognazzi, K" uniqKey="Tognazzi K">K Tognazzi</name>
</author>
<author><name sortKey="Dvorak, Hf" uniqKey="Dvorak H">HF Dvorak</name>
</author>
<author><name sortKey="Harrist, Tj" uniqKey="Harrist T">TJ Harrist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M Hashimoto</name>
</author>
<author><name sortKey="Ohsawa, M" uniqKey="Ohsawa M">M Ohsawa</name>
</author>
<author><name sortKey="Ohnishi, A" uniqKey="Ohnishi A">A Ohnishi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Itakura, E" uniqKey="Itakura E">E Itakura</name>
</author>
<author><name sortKey="Yamamoto, H" uniqKey="Yamamoto H">H Yamamoto</name>
</author>
<author><name sortKey="Oda, Y" uniqKey="Oda Y">Y Oda</name>
</author>
<author><name sortKey="Tsuneyoshi, M" uniqKey="Tsuneyoshi M">M Tsuneyoshi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lahat, G" uniqKey="Lahat G">G Lahat</name>
</author>
<author><name sortKey="Dhuka, Ar" uniqKey="Dhuka A">AR Dhuka</name>
</author>
<author><name sortKey="Hallevi, H" uniqKey="Hallevi H">H Hallevi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohsawa, M" uniqKey="Ohsawa M">M Ohsawa</name>
</author>
<author><name sortKey="Naka, N" uniqKey="Naka N">N Naka</name>
</author>
<author><name sortKey="Tomita, Y" uniqKey="Tomita Y">Y Tomita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stacher, E" uniqKey="Stacher E">E Stacher</name>
</author>
<author><name sortKey="Gruber Mosenbacher, U" uniqKey="Gruber Mosenbacher U">U Gruber-Mosenbacher</name>
</author>
<author><name sortKey="Halbwedl, I" uniqKey="Halbwedl I">I Halbwedl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tokuyama, W" uniqKey="Tokuyama W">W Tokuyama</name>
</author>
<author><name sortKey="Mikami, T" uniqKey="Mikami T">T Mikami</name>
</author>
<author><name sortKey="Masuzawa, M" uniqKey="Masuzawa M">M Masuzawa</name>
</author>
<author><name sortKey="Okayasu, I" uniqKey="Okayasu I">I Okayasu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zietz, C" uniqKey="Zietz C">C Zietz</name>
</author>
<author><name sortKey="Rossle, M" uniqKey="Rossle M">M Rossle</name>
</author>
<author><name sortKey="Haas, C" uniqKey="Haas C">C Haas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antonescu, Cr" uniqKey="Antonescu C">CR Antonescu</name>
</author>
<author><name sortKey="Yoshida, A" uniqKey="Yoshida A">A Yoshida</name>
</author>
<author><name sortKey="Guo, T" uniqKey="Guo T">T Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maki, Rg" uniqKey="Maki R">RG Maki</name>
</author>
<author><name sortKey="D Damo, Dr" uniqKey="D Damo D">DR D’Adamo</name>
</author>
<author><name sortKey="Keohan, Ml" uniqKey="Keohan M">ML Keohan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ray Coquard, I" uniqKey="Ray Coquard I">I Ray-Coquard</name>
</author>
<author><name sortKey="Italiano, A" uniqKey="Italiano A">A Italiano</name>
</author>
<author><name sortKey="Bompas, E" uniqKey="Bompas E">E Bompas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agulnik, M" uniqKey="Agulnik M">M Agulnik</name>
</author>
<author><name sortKey="O, S" uniqKey="O S">S O</name>
</author>
<author><name sortKey="Von Mehren, M" uniqKey="Von Mehren M">M von Mehren</name>
</author>
<author><name sortKey="Jovanovic, B" uniqKey="Jovanovic B">B Jovanovic</name>
</author>
<author><name sortKey="Brockstein, B" uniqKey="Brockstein B">B Brockstein</name>
</author>
<author><name sortKey="Benjamin, Rs" uniqKey="Benjamin R">RS Benjamin</name>
</author>
<author><name sortKey="Evens, Am" uniqKey="Evens A">AM Evens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosen, A" uniqKey="Rosen A">A Rosen</name>
</author>
<author><name sortKey="Thimon, S" uniqKey="Thimon S">S Thimon</name>
</author>
<author><name sortKey="Ternant, D" uniqKey="Ternant D">D Ternant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, H" uniqKey="Huang H">H Huang</name>
</author>
<author><name sortKey="Bhat, A" uniqKey="Bhat A">A Bhat</name>
</author>
<author><name sortKey="Woodnutt, G" uniqKey="Woodnutt G">G Woodnutt</name>
</author>
<author><name sortKey="Lappe, R" uniqKey="Lappe R">R Lappe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fukuhara, S" uniqKey="Fukuhara S">S Fukuhara</name>
</author>
<author><name sortKey="Sako, K" uniqKey="Sako K">K Sako</name>
</author>
<author><name sortKey="Minami, T" uniqKey="Minami T">T Minami</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fukuhara, S" uniqKey="Fukuhara S">S Fukuhara</name>
</author>
<author><name sortKey="Sako, K" uniqKey="Sako K">K Sako</name>
</author>
<author><name sortKey="Noda, K" uniqKey="Noda K">K Noda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kanda, S" uniqKey="Kanda S">S Kanda</name>
</author>
<author><name sortKey="Miyata, Y" uniqKey="Miyata Y">Y Miyata</name>
</author>
<author><name sortKey="Mochizuki, Y" uniqKey="Mochizuki Y">Y Mochizuki</name>
</author>
<author><name sortKey="Matsuyama, T" uniqKey="Matsuyama T">T Matsuyama</name>
</author>
<author><name sortKey="Kanetake, H" uniqKey="Kanetake H">H Kanetake</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saharinen, P" uniqKey="Saharinen P">P Saharinen</name>
</author>
<author><name sortKey="Eklund, L" uniqKey="Eklund L">L Eklund</name>
</author>
<author><name sortKey="Miettinen, J" uniqKey="Miettinen J">J Miettinen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, I" uniqKey="Kim I">I Kim</name>
</author>
<author><name sortKey="Kim, Hg" uniqKey="Kim H">HG Kim</name>
</author>
<author><name sortKey="So, Jn" uniqKey="So J">JN So</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name>
</author>
<author><name sortKey="Cheng, Sy" uniqKey="Cheng S">SY Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valenzuela, Dm" uniqKey="Valenzuela D">DM Valenzuela</name>
</author>
<author><name sortKey="Griffiths, Ja" uniqKey="Griffiths J">JA Griffiths</name>
</author>
<author><name sortKey="Rojas, J" uniqKey="Rojas J">J Rojas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brown, Lf" uniqKey="Brown L">LF Brown</name>
</author>
<author><name sortKey="Dezube, Bj" uniqKey="Dezube B">BJ Dezube</name>
</author>
<author><name sortKey="Tognazzi, K" uniqKey="Tognazzi K">K Tognazzi</name>
</author>
<author><name sortKey="Dvorak, Hf" uniqKey="Dvorak H">HF Dvorak</name>
</author>
<author><name sortKey="Yancopoulos, Gd" uniqKey="Yancopoulos G">GD Yancopoulos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hasenstein, Jr" uniqKey="Hasenstein J">JR Hasenstein</name>
</author>
<author><name sortKey="Kasmerchak, K" uniqKey="Kasmerchak K">K Kasmerchak</name>
</author>
<author><name sortKey="Buehler, D" uniqKey="Buehler D">D Buehler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shon, W" uniqKey="Shon W">W Shon</name>
</author>
<author><name sortKey="Jenkins, Sm" uniqKey="Jenkins S">SM Jenkins</name>
</author>
<author><name sortKey="Ross, Dt" uniqKey="Ross D">DT Ross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maisonpierre, Pc" uniqKey="Maisonpierre P">PC Maisonpierre</name>
</author>
<author><name sortKey="Suri, C" uniqKey="Suri C">C Suri</name>
</author>
<author><name sortKey="Jones, Pf" uniqKey="Jones P">PF Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suri, C" uniqKey="Suri C">C Suri</name>
</author>
<author><name sortKey="Jones, Pf" uniqKey="Jones P">PF Jones</name>
</author>
<author><name sortKey="Patan, S" uniqKey="Patan S">S Patan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gale, Nw" uniqKey="Gale N">NW Gale</name>
</author>
<author><name sortKey="Thurston, G" uniqKey="Thurston G">G Thurston</name>
</author>
<author><name sortKey="Hackett, Sf" uniqKey="Hackett S">SF Hackett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dumont, Dj" uniqKey="Dumont D">DJ Dumont</name>
</author>
<author><name sortKey="Gradwohl, G" uniqKey="Gradwohl G">G Gradwohl</name>
</author>
<author><name sortKey="Fong, Gh" uniqKey="Fong G">GH Fong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sato, Tn" uniqKey="Sato T">TN Sato</name>
</author>
<author><name sortKey="Tozawa, Y" uniqKey="Tozawa Y">Y Tozawa</name>
</author>
<author><name sortKey="Deutsch, U" uniqKey="Deutsch U">U Deutsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Puri, Mc" uniqKey="Puri M">MC Puri</name>
</author>
<author><name sortKey="Rossant, J" uniqKey="Rossant J">J Rossant</name>
</author>
<author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name>
</author>
<author><name sortKey="Bernstein, A" uniqKey="Bernstein A">A Bernstein</name>
</author>
<author><name sortKey="Partanen, J" uniqKey="Partanen J">J Partanen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chung, Yc" uniqKey="Chung Y">YC Chung</name>
</author>
<author><name sortKey="Hou, Yc" uniqKey="Hou Y">YC Hou</name>
</author>
<author><name sortKey="Chang, Cn" uniqKey="Chang C">CN Chang</name>
</author>
<author><name sortKey="Hseu, Th" uniqKey="Hseu T">TH Hseu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dhiwakar, M" uniqKey="Dhiwakar M">M Dhiwakar</name>
</author>
<author><name sortKey="M, J" uniqKey="M J">J M</name>
</author>
<author><name sortKey="Kay, Pa" uniqKey="Kay P">PA Kay</name>
</author>
<author><name sortKey="Robbins, Kt" uniqKey="Robbins K">KT Robbins</name>
</author>
<author><name sortKey="Ran, S" uniqKey="Ran S">S Ran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oka, N" uniqKey="Oka N">N Oka</name>
</author>
<author><name sortKey="Yamamoto, Y" uniqKey="Yamamoto Y">Y Yamamoto</name>
</author>
<author><name sortKey="Takahashi, M" uniqKey="Takahashi M">M Takahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tanaka, F" uniqKey="Tanaka F">F Tanaka</name>
</author>
<author><name sortKey="Ishikawa, S" uniqKey="Ishikawa S">S Ishikawa</name>
</author>
<author><name sortKey="Yanagihara, K" uniqKey="Yanagihara K">K Yanagihara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sfiligoi, C" uniqKey="Sfiligoi C">C Sfiligoi</name>
</author>
<author><name sortKey="De Luca, A" uniqKey="De Luca A">A de Luca</name>
</author>
<author><name sortKey="Cascone, I" uniqKey="Cascone I">I Cascone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitsuhashi, N" uniqKey="Mitsuhashi N">N Mitsuhashi</name>
</author>
<author><name sortKey="Shimizu, H" uniqKey="Shimizu H">H Shimizu</name>
</author>
<author><name sortKey="Ohtsuka, M" uniqKey="Ohtsuka M">M Ohtsuka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ahmad, Sa" uniqKey="Ahmad S">SA Ahmad</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name>
</author>
<author><name sortKey="Jung, Yd" uniqKey="Jung Y">YD Jung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Srirajaskanthan, R" uniqKey="Srirajaskanthan R">R Srirajaskanthan</name>
</author>
<author><name sortKey="Dancey, G" uniqKey="Dancey G">G Dancey</name>
</author>
<author><name sortKey="Hackshaw, A" uniqKey="Hackshaw A">A Hackshaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Mp" uniqKey="Wong M">MP Wong</name>
</author>
<author><name sortKey="Chan, Sy" uniqKey="Chan S">SY Chan</name>
</author>
<author><name sortKey="Fu, Kh" uniqKey="Fu K">KH Fu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lind, Aj" uniqKey="Lind A">AJ Lind</name>
</author>
<author><name sortKey="Wikstrom, P" uniqKey="Wikstrom P">P Wikstrom</name>
</author>
<author><name sortKey="Granfors, T" uniqKey="Granfors T">T Granfors</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hata, K" uniqKey="Hata K">K Hata</name>
</author>
<author><name sortKey="Nakayama, K" uniqKey="Nakayama K">K Nakayama</name>
</author>
<author><name sortKey="Fujiwaki, R" uniqKey="Fujiwaki R">R Fujiwaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schulz, P" uniqKey="Schulz P">P Schulz</name>
</author>
<author><name sortKey="Fischer, C" uniqKey="Fischer C">C Fischer</name>
</author>
<author><name sortKey="Detjen, Km" uniqKey="Detjen K">KM Detjen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herbst, Rs" uniqKey="Herbst R">RS Herbst</name>
</author>
<author><name sortKey="Hong, D" uniqKey="Hong D">D Hong</name>
</author>
<author><name sortKey="Chap, L" uniqKey="Chap L">L Chap</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlan, By" uniqKey="Karlan B">BY Karlan</name>
</author>
<author><name sortKey="Oza, Am" uniqKey="Oza A">AM Oza</name>
</author>
<author><name sortKey="Richardson, Ge" uniqKey="Richardson G">GE Richardson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mita, Ac" uniqKey="Mita A">AC Mita</name>
</author>
<author><name sortKey="Takimoto, Ch" uniqKey="Takimoto C">CH Takimoto</name>
</author>
<author><name sortKey="Mita, M" uniqKey="Mita M">M Mita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rini, B" uniqKey="Rini B">B Rini</name>
</author>
<author><name sortKey="Szczylik, C" uniqKey="Szczylik C">C Szczylik</name>
</author>
<author><name sortKey="Tannir, Nm" uniqKey="Tannir N">NM Tannir</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amo, Y" uniqKey="Amo Y">Y Amo</name>
</author>
<author><name sortKey="Masuzawa, M" uniqKey="Masuzawa M">M Masuzawa</name>
</author>
<author><name sortKey="Hamada, Y" uniqKey="Hamada Y">Y Hamada</name>
</author>
<author><name sortKey="Katsuoka, K" uniqKey="Katsuoka K">K Katsuoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davis, S" uniqKey="Davis S">S Davis</name>
</author>
<author><name sortKey="Aldrich, Th" uniqKey="Aldrich T">TH Aldrich</name>
</author>
<author><name sortKey="Jones, Pf" uniqKey="Jones P">PF Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Staton, Ca" uniqKey="Staton C">CA Staton</name>
</author>
<author><name sortKey="Valluru, M" uniqKey="Valluru M">M Valluru</name>
</author>
<author><name sortKey="Hoh, L" uniqKey="Hoh L">L Hoh</name>
</author>
<author><name sortKey="Reed, Mw" uniqKey="Reed M">MW Reed</name>
</author>
<author><name sortKey="Brown, Nj" uniqKey="Brown N">NJ Brown</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003655 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003655 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:3706492 |texte= Expression of Angiopoietin-TIE System Components in Angiosarcoma }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:23558570" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |