Feasibility of robot-assisted radical prostatectomy for very-high risk prostate cancer: surgical and oncological outcomes in men aged ≥70 years
Identifieur interne : 002A91 ( Main/Merge ); précédent : 002A90; suivant : 002A92Feasibility of robot-assisted radical prostatectomy for very-high risk prostate cancer: surgical and oncological outcomes in men aged ≥70 years
Auteurs : Kyo Chul Koo ; Dae Chul Jung ; Seung Hwan Lee ; Young Deuk Choi ; Byung Ha Chung ; Sung Joon Hong ; Koon Ho RhaSource :
- Prostate International [ 2287-8882 ] ; 2014.
Abstract
Robot-assisted radical prostatectomy with pelvic lymph node dissection (RALP-PLND) is a feasible treatment option for high-risk prostate cancer (HPCa), but remains controversial for very high-risk prostate cancer (VHPCa). We aimed to assess the feasibility of RALP-PLND in men ≥70 years with VHPCa features by comparing outcomes to those of HPCa.
Among patients aged ≥70 years who underwent RALP-PLND between 2005 and 2012, 101 HPCa patients (31%) (PSA≥20 ng/mL or biopsy Gleason 8–10 or cT3a) and 53 VHPCa patients (16%) (≥cT3b or cN1) were identified. Perioperative, functional, and oncological outcomes were compared between groups.
Perioperative outcomes including operative time (
RALP-PLND is a feasible option for VHPCa in elderly patients with satisfactory oncologic outcomes; however, functional outcomes were not as favorable. Patients who are unable to accept the risk of adjuvant therapy and its side effects or incontinence should be deterred from surgical treatment, and other options such as radiation therapy could be an alternative.
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DOI: 10.12954/PI.14050
PubMed: 25325024
PubMed Central: 4186956
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Feasibility of robot-assisted radical prostatectomy for very-high risk prostate cancer: surgical and oncological outcomes in men aged ≥70 years</title><author><name sortKey="Koo, Kyo Chul" sort="Koo, Kyo Chul" uniqKey="Koo K" first="Kyo Chul" last="Koo">Kyo Chul Koo</name></author><author><name sortKey="Jung, Dae Chul" sort="Jung, Dae Chul" uniqKey="Jung D" first="Dae Chul" last="Jung">Dae Chul Jung</name></author><author><name sortKey="Lee, Seung Hwan" sort="Lee, Seung Hwan" uniqKey="Lee S" first="Seung Hwan" last="Lee">Seung Hwan Lee</name></author><author><name sortKey="Choi, Young Deuk" sort="Choi, Young Deuk" uniqKey="Choi Y" first="Young Deuk" last="Choi">Young Deuk Choi</name></author><author><name sortKey="Chung, Byung Ha" sort="Chung, Byung Ha" uniqKey="Chung B" first="Byung Ha" last="Chung">Byung Ha Chung</name></author><author><name sortKey="Hong, Sung Joon" sort="Hong, Sung Joon" uniqKey="Hong S" first="Sung Joon" last="Hong">Sung Joon Hong</name></author><author><name sortKey="Rha, Koon Ho" sort="Rha, Koon Ho" uniqKey="Rha K" first="Koon Ho" last="Rha">Koon Ho Rha</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25325024</idno><idno type="pmc">4186956</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186956</idno><idno type="RBID">PMC:4186956</idno><idno type="doi">10.12954/PI.14050</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004588</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004588</idno><idno type="wicri:Area/Pmc/Curation">004587</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004587</idno><idno type="wicri:Area/Pmc/Checkpoint">001B59</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001B59</idno><idno type="wicri:Area/Ncbi/Merge">006C22</idno><idno type="wicri:Area/Ncbi/Curation">006C22</idno><idno type="wicri:Area/Ncbi/Checkpoint">006C22</idno><idno type="wicri:doubleKey">2287-8882:2014:Koo K:feasibility:of:robot</idno><idno type="wicri:Area/Main/Merge">002A91</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Feasibility of robot-assisted radical prostatectomy for very-high risk prostate cancer: surgical and oncological outcomes in men aged ≥70 years</title><author><name sortKey="Koo, Kyo Chul" sort="Koo, Kyo Chul" uniqKey="Koo K" first="Kyo Chul" last="Koo">Kyo Chul Koo</name></author><author><name sortKey="Jung, Dae Chul" sort="Jung, Dae Chul" uniqKey="Jung D" first="Dae Chul" last="Jung">Dae Chul Jung</name></author><author><name sortKey="Lee, Seung Hwan" sort="Lee, Seung Hwan" uniqKey="Lee S" first="Seung Hwan" last="Lee">Seung Hwan Lee</name></author><author><name sortKey="Choi, Young Deuk" sort="Choi, Young Deuk" uniqKey="Choi Y" first="Young Deuk" last="Choi">Young Deuk Choi</name></author><author><name sortKey="Chung, Byung Ha" sort="Chung, Byung Ha" uniqKey="Chung B" first="Byung Ha" last="Chung">Byung Ha Chung</name></author><author><name sortKey="Hong, Sung Joon" sort="Hong, Sung Joon" uniqKey="Hong S" first="Sung Joon" last="Hong">Sung Joon Hong</name></author><author><name sortKey="Rha, Koon Ho" sort="Rha, Koon Ho" uniqKey="Rha K" first="Koon Ho" last="Rha">Koon Ho Rha</name></author></analytic><series><title level="j">Prostate International</title><idno type="ISSN">2287-8882</idno><idno type="eISSN">2287-903X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Robot-assisted radical prostatectomy with pelvic lymph node dissection (RALP-PLND) is a feasible treatment option for high-risk prostate cancer (HPCa), but remains controversial for very high-risk prostate cancer (VHPCa). We aimed to assess the feasibility of RALP-PLND in men ≥70 years with VHPCa features by comparing outcomes to those of HPCa.</p></sec><sec><title>Methods</title><p>Among patients aged ≥70 years who underwent RALP-PLND between 2005 and 2012, 101 HPCa patients (31%) (PSA≥20 ng/mL or biopsy Gleason 8–10 or cT3a) and 53 VHPCa patients (16%) (≥cT3b or cN1) were identified. Perioperative, functional, and oncological outcomes were compared between groups.</p></sec><sec><title>Results</title><p>Perioperative outcomes including operative time (<italic>P</italic>=0.917), estimated blood loss (<italic>P</italic>=0.181), and complications (<italic>P</italic>=0.239) were comparable. Due to Gleason score downgrading, 19% of HPCa and 4% of VHPCa were actually of intermediate risk. VHPCa revealed higher LN involvements (<italic>P</italic>=0.002). Discrepancy between clinical and pathological nodal status was more frequent in VHPCa (36% vs. 7%, <italic>P</italic><0.01). Nodal metastasis would have been missed in 23% patients without PLND, while 13% of cN1 patients were shown to be metastasis-free by PLND. Continence rates were lower for VHPCa (32% vs. 56%, <italic>P</italic>=0.013). Although biochemical recurrence-free survival rates were comparable (<italic>P</italic>=0.648), risk for later adjuvant treatments was higher for VHPCa patients (14% vs. 34%, <italic>P</italic><0.01).</p></sec><sec><title>Conclusions</title><p>RALP-PLND is a feasible option for VHPCa in elderly patients with satisfactory oncologic outcomes; however, functional outcomes were not as favorable. Patients who are unable to accept the risk of adjuvant therapy and its side effects or incontinence should be deterred from surgical treatment, and other options such as radiation therapy could be an alternative.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name></author><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Choi, Jh" uniqKey="Choi J">JH Choi</name></author><author><name sortKey="Koo, Kc" uniqKey="Koo K">KC Koo</name></author><author><name sortKey="Lee, Dh" uniqKey="Lee D">DH Lee</name></author><author><name sortKey="Chung, Bh" uniqKey="Chung B">BH Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kunz, I" uniqKey="Kunz I">I Kunz</name></author><author><name sortKey="Musch, M" uniqKey="Musch M">M Musch</name></author><author><name sortKey="Roggenbuck, U" uniqKey="Roggenbuck U">U Roggenbuck</name></author><author><name sortKey="Klevecka, V" uniqKey="Klevecka V">V Klevecka</name></author><author><name sortKey="Kroepfl, D" uniqKey="Kroepfl D">D Kroepfl</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Liss, Ma" uniqKey="Liss M">MA Liss</name></author><author><name sortKey="Lusch, A" uniqKey="Lusch A">A Lusch</name></author><author><name sortKey="Morales, B" uniqKey="Morales B">B Morales</name></author><author><name sortKey="Beheshti, N" uniqKey="Beheshti N">N Beheshti</name></author><author><name sortKey="Skarecky, D" uniqKey="Skarecky D">D Skarecky</name></author><author><name sortKey="Narula, N" uniqKey="Narula N">N Narula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xylinas, E" uniqKey="Xylinas E">E Xylinas</name></author><author><name sortKey="Dache, A" uniqKey="Dache A">A Dache</name></author><author><name sortKey="Roupret, M" uniqKey="Roupret M">M Roupret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greco, Ka" uniqKey="Greco K">KA Greco</name></author><author><name sortKey="Meeks, Jj" uniqKey="Meeks J">JJ Meeks</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name></author><author><name sortKey="Nadler, Rb" uniqKey="Nadler R">RB Nadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, Yc" uniqKey="Ou Y">YC Ou</name></author><author><name sortKey="Yang, Ck" uniqKey="Yang C">CK Yang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Hung, Sw" uniqKey="Hung S">SW Hung</name></author><author><name sortKey="Cheng, Cl" uniqKey="Cheng C">CL Cheng</name></author><author><name sortKey="Tewari, Ak" uniqKey="Tewari A">AK Tewari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Punnen, S" uniqKey="Punnen S">S Punnen</name></author><author><name sortKey="Meng, Mv" uniqKey="Meng M">MV Meng</name></author><author><name sortKey="Cooperberg, Mr" uniqKey="Cooperberg M">MR Cooperberg</name></author><author><name sortKey="Greene, Kl" uniqKey="Greene K">KL Greene</name></author><author><name sortKey="Cowan, Je" uniqKey="Cowan J">JE Cowan</name></author><author><name sortKey="Carroll, Pr" uniqKey="Carroll P">PR Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierorazio, Pm" uniqKey="Pierorazio P">PM Pierorazio</name></author><author><name sortKey="Mullins, Jk" uniqKey="Mullins J">JK Mullins</name></author><author><name sortKey="Eifler, Jb" uniqKey="Eifler J">JB Eifler</name></author><author><name sortKey="Voth, K" uniqKey="Voth K">K Voth</name></author><author><name sortKey="Hyams, Es" uniqKey="Hyams E">ES Hyams</name></author><author><name sortKey="Han, M" uniqKey="Han M">M Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohler, Jl" uniqKey="Mohler J">JL Mohler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koo, Kc" uniqKey="Koo K">KC Koo</name></author><author><name sortKey="Lee, Dh" uniqKey="Lee D">DH Lee</name></author><author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name></author><author><name sortKey="Chung, Bh" uniqKey="Chung B">BH Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sridharan, S" uniqKey="Sridharan S">S Sridharan</name></author><author><name sortKey="Warde, P" uniqKey="Warde P">P Warde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jayram, G" uniqKey="Jayram G">G Jayram</name></author><author><name sortKey="Decastro, Gj" uniqKey="Decastro G">GJ Decastro</name></author><author><name sortKey="Large, Mc" uniqKey="Large M">MC Large</name></author><author><name sortKey="Razmaria, A" uniqKey="Razmaria A">A Razmaria</name></author><author><name sortKey="Zagaja, Gp" uniqKey="Zagaja G">GP Zagaja</name></author><author><name sortKey="Shalhav, Al" uniqKey="Shalhav A">AL Shalhav</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oderda, M" uniqKey="Oderda M">M Oderda</name></author><author><name sortKey="Joniau, S" uniqKey="Joniau S">S Joniau</name></author><author><name sortKey="Spahn, M" uniqKey="Spahn M">M Spahn</name></author><author><name sortKey="Gontero, P" uniqKey="Gontero P">P Gontero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alibhai, Sm" uniqKey="Alibhai S">SM Alibhai</name></author><author><name sortKey="Naglie, G" uniqKey="Naglie G">G Naglie</name></author><author><name sortKey="Nam, R" uniqKey="Nam R">R Nam</name></author><author><name sortKey="Trachtenberg, J" uniqKey="Trachtenberg J">J Trachtenberg</name></author><author><name sortKey="Krahn, Md" uniqKey="Krahn M">MD Krahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albertsen, Pc" uniqKey="Albertsen P">PC Albertsen</name></author><author><name sortKey="Hanley, Ja" uniqKey="Hanley J">JA Hanley</name></author><author><name sortKey="Fine, J" uniqKey="Fine J">J Fine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ko, J" uniqKey="Ko J">J Ko</name></author><author><name sortKey="Falzarano, Sm" uniqKey="Falzarano S">SM Falzarano</name></author><author><name sortKey="Walker, E" uniqKey="Walker E">E Walker</name></author><author><name sortKey="Streator Smith, K" uniqKey="Streator Smith K">K Streator Smith</name></author><author><name sortKey="Stephenson, Aj" uniqKey="Stephenson A">AJ Stephenson</name></author><author><name sortKey="Klein, Ea" uniqKey="Klein E">EA Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogers, Cg" uniqKey="Rogers C">CG Rogers</name></author><author><name sortKey="Sammon, Jd" uniqKey="Sammon J">JD Sammon</name></author><author><name sortKey="Sukumar, S" uniqKey="Sukumar S">S Sukumar</name></author><author><name sortKey="Diaz, M" uniqKey="Diaz M">M Diaz</name></author><author><name sortKey="Peabody, J" uniqKey="Peabody J">J Peabody</name></author><author><name sortKey="Menon, M" uniqKey="Menon M">M Menon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, Ma" uniqKey="Hall M">MA Hall</name></author><author><name sortKey="Kwon, S" uniqKey="Kwon S">S Kwon</name></author><author><name sortKey="Robinson, H" uniqKey="Robinson H">H Robinson</name></author><author><name sortKey="Lachance, Pa" uniqKey="Lachance P">PA Lachance</name></author><author><name sortKey="Azhdarinia, A" uniqKey="Azhdarinia A">A Azhdarinia</name></author><author><name sortKey="Ranganathan, R" uniqKey="Ranganathan R">R Ranganathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooperberg, Mr" uniqKey="Cooperberg M">MR Cooperberg</name></author><author><name sortKey="Grossfeld, Gd" uniqKey="Grossfeld G">GD Grossfeld</name></author><author><name sortKey="Lubeck, Dp" uniqKey="Lubeck D">DP Lubeck</name></author><author><name sortKey="Carroll, Pr" uniqKey="Carroll P">PR Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bader, P" uniqKey="Bader P">P Bader</name></author><author><name sortKey="Burkhard, Fc" uniqKey="Burkhard F">FC Burkhard</name></author><author><name sortKey="Markwalder, R" uniqKey="Markwalder R">R Markwalder</name></author><author><name sortKey="Studer, Ue" uniqKey="Studer U">UE Studer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shikanov, S" uniqKey="Shikanov S">S Shikanov</name></author><author><name sortKey="Desai, V" uniqKey="Desai V">V Desai</name></author><author><name sortKey="Razmaria, A" uniqKey="Razmaria A">A Razmaria</name></author><author><name sortKey="Zagaja, Gp" uniqKey="Zagaja G">GP Zagaja</name></author><author><name sortKey="Shalhav, Al" uniqKey="Shalhav A">AL Shalhav</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sooriakumaran, P" uniqKey="Sooriakumaran P">P Sooriakumaran</name></author><author><name sortKey="Haendler, L" uniqKey="Haendler L">L Haendler</name></author><author><name sortKey="Nyberg, T" uniqKey="Nyberg T">T Nyberg</name></author><author><name sortKey="Gronberg, H" uniqKey="Gronberg H">H Gronberg</name></author><author><name sortKey="Nilsson, A" uniqKey="Nilsson A">A Nilsson</name></author><author><name sortKey="Carlsson, S" uniqKey="Carlsson S">S Carlsson</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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