Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness
Identifieur interne : 002400 ( Main/Merge ); précédent : 002399; suivant : 002401Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness
Auteurs : Martin Walker [Royaume-Uni] ; Sabine Specht [Allemagne] ; Thomas S. Churcher [Royaume-Uni] ; Achim Hoerauf [Allemagne] ; Mark J. Taylor [Royaume-Uni] ; María-Gloria Basá Ez [Royaume-Uni]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2014.
Abstract
The efficacy of 4–6 weeks of oral doxycycline in depleting
Url:
DOI: 10.1093/cid/ciu1152
PubMed: 25537873
PubMed Central: 4370165
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PMC:4370165Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The efficacy of 4–6 weeks of oral doxycycline in depleting <italic>Wolbachia</italic>
from <italic>Onchocerca volvulus</italic>
is >95% in the majority of patients. <italic>Wolbachia</italic>
depletion induces a 70%–80% reduction in worm life span, confirming doxycycline as a potent macrofilaricide.</p>
</div>
</front>
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<author><name sortKey="Awadzi, K" uniqKey="Awadzi K">K Awadzi</name>
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<author><name sortKey="Basa Ez, M G" uniqKey="Basa Ez M">M-G Basáñez</name>
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<author><name sortKey="Pion, Sd" uniqKey="Pion S">SD Pion</name>
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<author><name sortKey="Osei Atweneboana, My" uniqKey="Osei Atweneboana M">MY Osei-Atweneboana</name>
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<author><name sortKey="Eng, Jk" uniqKey="Eng J">JK Eng</name>
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<author><name sortKey="Boakye, Da" uniqKey="Boakye D">DA Boakye</name>
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