Saraca indica Bark Extract Shows In Vitro Antioxidant, Antibreast Cancer Activity and Does Not Exhibit Toxicological Effects
Identifieur interne : 002271 ( Main/Merge ); précédent : 002270; suivant : 002272Saraca indica Bark Extract Shows In Vitro Antioxidant, Antibreast Cancer Activity and Does Not Exhibit Toxicological Effects
Auteurs : Navneet Kumar Yadav [Inde] ; Karan Singh Saini [Inde] ; Zakir Hossain [Inde] ; Ankur Omer [Inde] ; Chetan Sharma [Inde] ; Jiaur R. Gayen [Inde] ; Poonam Singh [Inde] ; K. R. Arya [Inde] ; R. K. Singh [Inde]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2015.
Abstract
Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability.
Url:
DOI: 10.1155/2015/205360
PubMed: 25861411
PubMed Central: 4378602
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Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation></author><author><name sortKey="Gayen, Jiaur R" sort="Gayen, Jiaur R" uniqKey="Gayen J" first="Jiaur R." last="Gayen">Jiaur R. Gayen</name><affiliation wicri:level="1"><nlm:aff id="I3">Division of Pharmacokinetics & Metabolism, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Pharmacokinetics & Metabolism, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Poonam" sort="Singh, Poonam" uniqKey="Singh P" first="Poonam" last="Singh">Poonam Singh</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation></author><author><name sortKey="Arya, K R" sort="Arya, K R" uniqKey="Arya K" first="K. R." last="Arya">K. R. Arya</name><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I5">Division of Botany, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Botany, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation></author><author><name sortKey="Singh, R K" sort="Singh, R K" uniqKey="Singh R" first="R. K." last="Singh">R. K. Singh</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25861411</idno><idno type="pmc">4378602</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378602</idno><idno type="RBID">PMC:4378602</idno><idno type="doi">10.1155/2015/205360</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">004287</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004287</idno><idno type="wicri:Area/Pmc/Curation">004286</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004286</idno><idno type="wicri:Area/Pmc/Checkpoint">001601</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001601</idno><idno type="wicri:Area/Ncbi/Merge">007240</idno><idno type="wicri:Area/Ncbi/Curation">007240</idno><idno type="wicri:Area/Ncbi/Checkpoint">007240</idno><idno type="wicri:Area/Main/Merge">002271</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Saraca indica</italic> Bark Extract Shows <italic>In Vitro</italic> Antioxidant, Antibreast Cancer Activity and Does Not Exhibit Toxicological Effects</title><author><name sortKey="Yadav, Navneet Kumar" sort="Yadav, Navneet Kumar" uniqKey="Yadav N" first="Navneet Kumar" last="Yadav">Navneet Kumar Yadav</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation></author><author><name sortKey="Saini, Karan Singh" sort="Saini, Karan Singh" uniqKey="Saini K" first="Karan Singh" last="Saini">Karan Singh Saini</name><affiliation wicri:level="1"><nlm:aff id="I2">Division of Endocrinology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Endocrinology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation></author><author><name sortKey="Hossain, Zakir" sort="Hossain, Zakir" uniqKey="Hossain Z" first="Zakir" last="Hossain">Zakir Hossain</name><affiliation wicri:level="1"><nlm:aff id="I3">Division of Pharmacokinetics & Metabolism, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Pharmacokinetics & Metabolism, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation></author><author><name sortKey="Omer, Ankur" sort="Omer, Ankur" uniqKey="Omer A" first="Ankur" last="Omer">Ankur Omer</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Chetan" sort="Sharma, Chetan" uniqKey="Sharma C" first="Chetan" last="Sharma">Chetan Sharma</name><affiliation wicri:level="1"><nlm:aff id="I5">Division of Botany, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Botany, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation></author><author><name sortKey="Gayen, Jiaur R" sort="Gayen, Jiaur R" uniqKey="Gayen J" first="Jiaur R." last="Gayen">Jiaur R. Gayen</name><affiliation wicri:level="1"><nlm:aff id="I3">Division of Pharmacokinetics & Metabolism, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Pharmacokinetics & Metabolism, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Poonam" sort="Singh, Poonam" uniqKey="Singh P" first="Poonam" last="Singh">Poonam Singh</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation></author><author><name sortKey="Arya, K R" sort="Arya, K R" uniqKey="Arya K" first="K. R." last="Arya">K. R. Arya</name><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I5">Division of Botany, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Botany, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation></author><author><name sortKey="Singh, R K" sort="Singh, R K" uniqKey="Singh R" first="R. K." last="Singh">R. K. Singh</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031</wicri:regionArea><wicri:noRegion>Lucknow 226031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Academy of Scientific and Innovative Research, New Delhi 110 001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research, New Delhi 110 001</wicri:regionArea><wicri:noRegion>New Delhi 110 001</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability. <italic>Saraca indica</italic> (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects. Antioxidant, antibreast cancer activity and toxicological evaluation of <italic>Saraca indica bark extract</italic> (SIE) were carried out in the present study. The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity. Toxicological studies suggest that SIE is safer to use and may have a potential to be used as complementary and alternative medicine for breast cancer therapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Prasad, S" uniqKey="Prasad S">S. 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Al-Lazikani</name></author><author><name sortKey="Banerji, U" uniqKey="Banerji U">U. Banerji</name></author><author><name sortKey="Workman, P" uniqKey="Workman P">P. Workman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa, M A" uniqKey="Costa M">M. A. Costa</name></author><author><name sortKey="Palazzo De Mello, J C" uniqKey="Palazzo De Mello J">J. C. Palazzo De Mello</name></author><author><name sortKey="Kaneshima, E N" uniqKey="Kaneshima E">E. N. Kaneshima</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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