C-MYC positive angiosarcoma of skin and breast following MammoSite® treatment.
Identifieur interne : 002063 ( Main/Merge ); précédent : 002062; suivant : 002064C-MYC positive angiosarcoma of skin and breast following MammoSite® treatment.
Auteurs : W James Tidwell [Oman] ; Jim Haq ; Kamila F. Kozlowski ; Paul B. GoogeSource :
- Dermatology online journal [ 1087-2108 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Biopsie, Curiethérapie (effets indésirables), Diagnostic différentiel, Facteurs de transcription (métabolisme), Femelle, Gènes myc, Humains, Hémangiosarcome (anatomopathologie), Hémangiosarcome (métabolisme), Hémangiosarcome (étiologie), Marqueurs biologiques tumoraux (métabolisme), Mastectomie (effets indésirables), Protéines de liaison à l'ADN (métabolisme), Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (métabolisme), Tumeurs cutanées (étiologie), Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie), Tumeurs radio-induites (anatomopathologie), Tumeurs radio-induites (métabolisme), Tumeurs radio-induites (étiologie).
- MESH :
- anatomopathologie : Hémangiosarcome, Tumeurs cutanées, Tumeurs du sein, Tumeurs radio-induites.
- effets indésirables : Curiethérapie, Mastectomie.
- métabolisme : Facteurs de transcription, Hémangiosarcome, Marqueurs biologiques tumoraux, Protéines de liaison à l'ADN, Tumeurs cutanées, Tumeurs radio-induites.
- radiothérapie : Tumeurs du sein.
- étiologie : Hémangiosarcome, Tumeurs cutanées, Tumeurs radio-induites.
- Adulte d'âge moyen, Biopsie, Diagnostic différentiel, Femelle, Gènes myc, Humains, Tumeurs du sein.
English descriptors
- KwdEn :
- Biomarkers, Tumor (metabolism), Biopsy, Brachytherapy (adverse effects), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), DNA-Binding Proteins (metabolism), Diagnosis, Differential, Female, Genes, myc, Hemangiosarcoma (etiology), Hemangiosarcoma (metabolism), Hemangiosarcoma (pathology), Humans, Mastectomy (adverse effects), Middle Aged, Neoplasms, Radiation-Induced (etiology), Neoplasms, Radiation-Induced (metabolism), Neoplasms, Radiation-Induced (pathology), Skin Neoplasms (etiology), Skin Neoplasms (metabolism), Skin Neoplasms (pathology), Transcription Factors (metabolism).
- MESH :
- chemical , metabolism : Biomarkers, Tumor, DNA-Binding Proteins, Transcription Factors.
- adverse effects : Brachytherapy, Mastectomy.
- etiology : Hemangiosarcoma, Neoplasms, Radiation-Induced, Skin Neoplasms.
- metabolism : Hemangiosarcoma, Neoplasms, Radiation-Induced, Skin Neoplasms.
- pathology : Breast Neoplasms, Hemangiosarcoma, Neoplasms, Radiation-Induced, Skin Neoplasms.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Biopsy, Diagnosis, Differential, Female, Genes, myc, Humans, Middle Aged.
Abstract
Angiosarcoma of the skin and breast is a known complication of chronic lymphedema following mastectomy or external radiation therapy for breast cancer. We report a 68-year-old woman who presented with a 2.5 cm violaceous plaque on the skin of the right breast and a 3 cm mixed mass of the same breast by ultrasound 9 years after MammoSite® balloon brachytherapy. Biopsy of the skin lesion and the breast mass showed an infiltrating high grade angiosarcoma. The tumor cells in the skin and breast showed immunohistochemical reactivity for C-MYC. A total mastectomy confirmed the presence of high grade angiosarcoma in the skin and parenchyma of the breast and radiation changes in the breast parenchyma. Surgical margins were considered negative. The patient had cutaneous recurrence of angiosarcoma three months after the mastectomy. There have been only two other case reports in the literature of angiosarcoma on the skin following MammoSite® therapy. The c-myc mutation has been shown to be a specific mutation for angiosarcoma following radiation treatment. It is not found in atypical vascular lesions following irradiation or angiosarcoma unrelated to radiation treatment.
PubMed: 26632799
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pubmed:26632799Le document en format XML
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<author><name sortKey="Tidwell, W James" sort="Tidwell, W James" uniqKey="Tidwell W" first="W James" last="Tidwell">W James Tidwell</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Louisville Division of Dermatology; University of Tennessee Graduate School of Medicine. wjamestidwell@gmail.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
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<author><name sortKey="Haq, Jim" sort="Haq, Jim" uniqKey="Haq J" first="Jim" last="Haq">Jim Haq</name>
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<author><name sortKey="Kozlowski, Kamila F" sort="Kozlowski, Kamila F" uniqKey="Kozlowski K" first="Kamila F" last="Kozlowski">Kamila F. Kozlowski</name>
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<author><name sortKey="Googe, Paul B" sort="Googe, Paul B" uniqKey="Googe P" first="Paul B" last="Googe">Paul B. Googe</name>
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<affiliation wicri:level="1"><nlm:affiliation>University of Louisville Division of Dermatology; University of Tennessee Graduate School of Medicine. wjamestidwell@gmail.com.</nlm:affiliation>
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<author><name sortKey="Haq, Jim" sort="Haq, Jim" uniqKey="Haq J" first="Jim" last="Haq">Jim Haq</name>
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<author><name sortKey="Kozlowski, Kamila F" sort="Kozlowski, Kamila F" uniqKey="Kozlowski K" first="Kamila F" last="Kozlowski">Kamila F. Kozlowski</name>
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<author><name sortKey="Googe, Paul B" sort="Googe, Paul B" uniqKey="Googe P" first="Paul B" last="Googe">Paul B. Googe</name>
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<series><title level="j">Dermatology online journal</title>
<idno type="eISSN">1087-2108</idno>
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<term>Biopsy</term>
<term>Brachytherapy (adverse effects)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Breast Neoplasms (surgery)</term>
<term>DNA-Binding Proteins (metabolism)</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Genes, myc</term>
<term>Hemangiosarcoma (etiology)</term>
<term>Hemangiosarcoma (metabolism)</term>
<term>Hemangiosarcoma (pathology)</term>
<term>Humans</term>
<term>Mastectomy (adverse effects)</term>
<term>Middle Aged</term>
<term>Neoplasms, Radiation-Induced (etiology)</term>
<term>Neoplasms, Radiation-Induced (metabolism)</term>
<term>Neoplasms, Radiation-Induced (pathology)</term>
<term>Skin Neoplasms (etiology)</term>
<term>Skin Neoplasms (metabolism)</term>
<term>Skin Neoplasms (pathology)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Curiethérapie (effets indésirables)</term>
<term>Diagnostic différentiel</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Femelle</term>
<term>Gènes myc</term>
<term>Humains</term>
<term>Hémangiosarcome (anatomopathologie)</term>
<term>Hémangiosarcome (métabolisme)</term>
<term>Hémangiosarcome (étiologie)</term>
<term>Marqueurs biologiques tumoraux (métabolisme)</term>
<term>Mastectomie (effets indésirables)</term>
<term>Protéines de liaison à l'ADN (métabolisme)</term>
<term>Tumeurs cutanées (anatomopathologie)</term>
<term>Tumeurs cutanées (métabolisme)</term>
<term>Tumeurs cutanées (étiologie)</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (radiothérapie)</term>
<term>Tumeurs radio-induites (anatomopathologie)</term>
<term>Tumeurs radio-induites (métabolisme)</term>
<term>Tumeurs radio-induites (étiologie)</term>
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<term>DNA-Binding Proteins</term>
<term>Transcription Factors</term>
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<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Brachytherapy</term>
<term>Mastectomy</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hémangiosarcome</term>
<term>Tumeurs cutanées</term>
<term>Tumeurs du sein</term>
<term>Tumeurs radio-induites</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Curiethérapie</term>
<term>Mastectomie</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hemangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hemangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Hémangiosarcome</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Protéines de liaison à l'ADN</term>
<term>Tumeurs cutanées</term>
<term>Tumeurs radio-induites</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Hemangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hémangiosarcome</term>
<term>Tumeurs cutanées</term>
<term>Tumeurs radio-induites</term>
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<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Genes, myc</term>
<term>Humans</term>
<term>Middle Aged</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Diagnostic différentiel</term>
<term>Femelle</term>
<term>Gènes myc</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">Angiosarcoma of the skin and breast is a known complication of chronic lymphedema following mastectomy or external radiation therapy for breast cancer. We report a 68-year-old woman who presented with a 2.5 cm violaceous plaque on the skin of the right breast and a 3 cm mixed mass of the same breast by ultrasound 9 years after MammoSite® balloon brachytherapy. Biopsy of the skin lesion and the breast mass showed an infiltrating high grade angiosarcoma. The tumor cells in the skin and breast showed immunohistochemical reactivity for C-MYC. A total mastectomy confirmed the presence of high grade angiosarcoma in the skin and parenchyma of the breast and radiation changes in the breast parenchyma. Surgical margins were considered negative. The patient had cutaneous recurrence of angiosarcoma three months after the mastectomy. There have been only two other case reports in the literature of angiosarcoma on the skin following MammoSite® therapy. The c-myc mutation has been shown to be a specific mutation for angiosarcoma following radiation treatment. It is not found in atypical vascular lesions following irradiation or angiosarcoma unrelated to radiation treatment.</div>
</front>
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