Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial.
Identifieur interne : 001686 ( Main/Merge ); précédent : 001685; suivant : 001687Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial.
Auteurs : K. Papp [Canada] ; D. Thaçi [Allemagne] ; K. Reich [Allemagne] ; E. Riedl [Autriche] ; R G Langley [Canada] ; J G Krueger [États-Unis] ; A B Gottlieb [États-Unis] ; H. Nakagawa [Japon] ; E P Bowman [États-Unis] ; A. Mehta [États-Unis] ; Q. Li [États-Unis] ; Y. Zhou [États-Unis] ; R. Shames [États-Unis]Source :
- The British journal of dermatology [ 1365-2133 ] ; 2015.
Descripteurs français
- KwdFr :
- Administration par voie cutanée, Adolescent, Adulte, Adulte d'âge moyen, Anticorps monoclonaux (administration et posologie), Anticorps monoclonaux (effets indésirables), Anticorps monoclonaux (pharmacocinétique), Anticorps monoclonaux humanisés (administration et posologie), Anticorps monoclonaux humanisés (effets indésirables), Anticorps monoclonaux humanisés (pharmacocinétique), Calendrier d'administration des médicaments, Femelle, Humains, Jeune adulte, Mâle, Méthode en double aveugle, Produits dermatologiques (administration et posologie), Produits dermatologiques (effets indésirables), Produits dermatologiques (pharmacocinétique), Psoriasis (traitement médicamenteux), Résultat thérapeutique, Sous-unité p19 de l'interleukine-23 (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- administration et posologie : Anticorps monoclonaux, Anticorps monoclonaux humanisés, Produits dermatologiques.
- effets indésirables : Anticorps monoclonaux, Anticorps monoclonaux humanisés, Produits dermatologiques.
- immunologie : Sous-unité p19 de l'interleukine-23.
- pharmacocinétique : Anticorps monoclonaux, Anticorps monoclonaux humanisés, Produits dermatologiques.
- traitement médicamenteux : Psoriasis.
- Administration par voie cutanée, Adolescent, Adulte, Adulte d'âge moyen, Calendrier d'administration des médicaments, Femelle, Humains, Jeune adulte, Mâle, Méthode en double aveugle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Administration, Cutaneous, Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal (administration & dosage), Antibodies, Monoclonal (adverse effects), Antibodies, Monoclonal (pharmacokinetics), Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (pharmacokinetics), Dermatologic Agents (administration & dosage), Dermatologic Agents (adverse effects), Dermatologic Agents (pharmacokinetics), Double-Blind Method, Drug Administration Schedule, Female, Humans, Interleukin-23 Subunit p19 (immunology), Male, Middle Aged, Psoriasis (drug therapy), Treatment Outcome, Young Adult.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Dermatologic Agents.
- chemical , adverse effects : Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Dermatologic Agents.
- chemical , immunology : Interleukin-23 Subunit p19.
- chemical , pharmacokinetics : Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Dermatologic Agents.
- drug therapy : Psoriasis.
- Administration, Cutaneous, Adolescent, Adult, Aged, Aged, 80 and over, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Treatment Outcome, Young Adult.
Abstract
Tildrakizumab is a high-affinity, humanized, IgG1/κ, anti-interleukin (IL)-23p19 monoclonal antibody that does not bind human IL-12 or p40 is being developed for the treatment of chronic plaque psoriasis.
DOI: 10.1111/bjd.13932
PubMed: 26042589
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000E52
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- to stream Ncbi, to step Curation: 007458
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pubmed:26042589Le document en format XML
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<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie cutanée</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Calendrier d'administration des médicaments</term>
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<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
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<front><div type="abstract" xml:lang="en">Tildrakizumab is a high-affinity, humanized, IgG1/κ, anti-interleukin (IL)-23p19 monoclonal antibody that does not bind human IL-12 or p40 is being developed for the treatment of chronic plaque psoriasis.</div>
</front>
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