High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis.
Identifieur interne : 00BD22 ( Main/Exploration ); précédent : 00BD21; suivant : 00BD23High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis.
Auteurs : S. Mahanty [États-Unis] ; S N Mollis ; M. Ravichandran ; J S Abrams ; V. Kumaraswami ; K. Jayaraman ; E A Ottesen ; T B NutmanSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1996.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe, Enfant, Facteur de nécrose tumorale alpha (biosynthèse), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Humains, Interleukine-10 (biosynthèse), Interleukine-6 (biosynthèse), Lymphocytes T (immunologie), Monocytes (immunologie), Mâle, Régulation négative, Techniques in vitro, Tolérance immunitaire, Wuchereria bancrofti (immunologie).
- MESH :
- biosynthèse : Facteur de nécrose tumorale alpha, Interleukine-10, Interleukine-6.
- immunologie : Filariose lymphatique, Lymphocytes T, Monocytes, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- sang : Anticorps antihelminthe.
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe, Enfant, Femelle, Humains, Mâle, Régulation négative, Techniques in vitro, Tolérance immunitaire.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antibodies, Helminth (blood), Antigens, Helminth, Child, Down-Regulation, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Female, Humans, Immune Tolerance, In Vitro Techniques, Interleukin-10 (biosynthesis), Interleukin-6 (biosynthesis), Lymphocyte Activation, Male, Middle Aged, Monocytes (immunology), T-Lymphocytes (immunology), Tumor Necrosis Factor-alpha (biosynthesis), Wuchereria bancrofti (immunology).
- MESH :
- chemical , biosynthesis : Interleukin-10, Interleukin-6, Tumor Necrosis Factor-alpha.
- chemical , blood : Antibodies, Helminth.
- immunology : Elephantiasis, Filarial, Monocytes, T-Lymphocytes, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Antigens, Helminth, Child, Down-Regulation, Female, Humans, Immune Tolerance, In Vitro Techniques, Lymphocyte Activation, Male, Middle Aged.
Abstract
To determine whether counterregulation by interleukin (IL)-10 plays a role in the generation or maintenance of the antigen-specific hyporesponsiveness seen in asymptomatic microfilaremic (MF) patients, parasite antigen (PAg)- and nonparasite antigen (NPAg)-driven IL-10 production by peripheral blood mononuclear cells (PBMC) was studied in 10 MF patients and in ll patients with chronic lymphatic pathology (CP). PBMC from MF patients spontaneously secreted 10-fold more IL-10 than did PBMC from patients with CP. PAg also induced significantly more IL-10 production by PBMC from CP patients. There was a negative correlation between PAg driven IL-10 production by PBMC and PAg-specific T cell proliferation in the MF group. IL-10 secretion by plastic adherent cells from MF persons was higher in response to PAg than NPAg, whereas IL-6 and tumor necrosis factor-alpha secretion were equivalent for PAg and NPAg, suggesting that PAg preferentially induces IL-10 secretion in these cells. Thus, PAg-induced IL-10 likely plays an important role in down-regulating antigen-specific proliferative responses in MF patients.
PubMed: 8627051
Affiliations:
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Le document en format XML
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Mahanty</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Mollis, S N" sort="Mollis, S N" uniqKey="Mollis S" first="S N" last="Mollis">S N Mollis</name></author><author><name sortKey="Ravichandran, M" sort="Ravichandran, M" uniqKey="Ravichandran M" first="M" last="Ravichandran">M. 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Mahanty</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Mollis, S N" sort="Mollis, S N" uniqKey="Mollis S" first="S N" last="Mollis">S N Mollis</name></author><author><name sortKey="Ravichandran, M" sort="Ravichandran, M" uniqKey="Ravichandran M" first="M" last="Ravichandran">M. Ravichandran</name></author><author><name sortKey="Abrams, J S" sort="Abrams, J S" uniqKey="Abrams J" first="J S" last="Abrams">J S Abrams</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Jayaraman, K" sort="Jayaraman, K" uniqKey="Jayaraman K" first="K" last="Jayaraman">K. Jayaraman</name></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth</term><term>Child</term><term>Down-Regulation</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>In Vitro Techniques</term><term>Interleukin-10 (biosynthesis)</term><term>Interleukin-6 (biosynthesis)</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>Monocytes (immunology)</term><term>T-Lymphocytes (immunology)</term><term>Tumor Necrosis Factor-alpha (biosynthesis)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe</term><term>Enfant</term><term>Facteur de nécrose tumorale alpha (biosynthèse)</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Humains</term><term>Interleukine-10 (biosynthèse)</term><term>Interleukine-6 (biosynthèse)</term><term>Lymphocytes T (immunologie)</term><term>Monocytes (immunologie)</term><term>Mâle</term><term>Régulation négative</term><term>Techniques in vitro</term><term>Tolérance immunitaire</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukin-10</term><term>Interleukin-6</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Interleukine-10</term><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphocytes T</term><term>Monocytes</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Monocytes</term><term>T-Lymphocytes</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antigens, Helminth</term><term>Child</term><term>Down-Regulation</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>In Vitro Techniques</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Antigènes d'helminthe</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Régulation négative</term><term>Techniques in vitro</term><term>Tolérance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether counterregulation by interleukin (IL)-10 plays a role in the generation or maintenance of the antigen-specific hyporesponsiveness seen in asymptomatic microfilaremic (MF) patients, parasite antigen (PAg)- and nonparasite antigen (NPAg)-driven IL-10 production by peripheral blood mononuclear cells (PBMC) was studied in 10 MF patients and in ll patients with chronic lymphatic pathology (CP). PBMC from MF patients spontaneously secreted 10-fold more IL-10 than did PBMC from patients with CP. PAg also induced significantly more IL-10 production by PBMC from CP patients. There was a negative correlation between PAg driven IL-10 production by PBMC and PAg-specific T cell proliferation in the MF group. IL-10 secretion by plastic adherent cells from MF persons was higher in response to PAg than NPAg, whereas IL-6 and tumor necrosis factor-alpha secretion were equivalent for PAg and NPAg, suggesting that PAg preferentially induces IL-10 secretion in these cells. Thus, PAg-induced IL-10 likely plays an important role in down-regulating antigen-specific proliferative responses in MF patients.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Abrams, J S" sort="Abrams, J S" uniqKey="Abrams J" first="J S" last="Abrams">J S Abrams</name><name sortKey="Jayaraman, K" sort="Jayaraman, K" uniqKey="Jayaraman K" first="K" last="Jayaraman">K. Jayaraman</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name><name sortKey="Mollis, S N" sort="Mollis, S N" uniqKey="Mollis S" first="S N" last="Mollis">S N Mollis</name><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name><name sortKey="Ravichandran, M" sort="Ravichandran, M" uniqKey="Ravichandran M" first="M" last="Ravichandran">M. Ravichandran</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Mahanty, S" sort="Mahanty, S" uniqKey="Mahanty S" first="S" last="Mahanty">S. Mahanty</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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