Community diagnosis of Bancroftian filariasis.
Identifieur interne : 012E55 ( Main/Exploration ); précédent : 012E54; suivant : 012E56Community diagnosis of Bancroftian filariasis.
Auteurs : R. Faris [Égypte] ; R M Ramzy ; A M Gad ; G J Weil ; A A BuckSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (analyse), Enfant, Femelle, Filariose lymphatique (diagnostic), Filariose lymphatique (épidémiologie), Humains, Mâle, Prévalence, Sensibilité et spécificité, Sujet âgé, Valeur prédictive des tests, Wuchereria bancrofti (immunologie), Wuchereria bancrofti (isolement et purification), Égypte (épidémiologie).
- MESH :
- analyse : Antigènes d'helminthe.
- diagnostic : Filariose lymphatique.
- immunologie : Wuchereria bancrofti.
- isolement et purification : Wuchereria bancrofti.
- épidémiologie : Filariose lymphatique, Égypte.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Femelle, Humains, Mâle, Prévalence, Sensibilité et spécificité, Sujet âgé, Valeur prédictive des tests.
- Wicri :
- geographic : Égypte.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antigens, Helminth (analysis), Child, Egypt (epidemiology), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prevalence, Sensitivity and Specificity, Wuchereria bancrofti (immunology), Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , analysis : Antigens, Helminth.
- geographic , epidemiology : Egypt.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Wuchereria bancrofti.
- isolation & purification : Wuchereria bancrofti.
- Adolescent, Adult, Aged, Animals, Child, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prevalence, Sensitivity and Specificity.
Abstract
The objective of this study was to find the best tests for efficiently estimating the true prevalence of Bancroftian filariasis in endemic areas. The study population comprised 427 people over 10 years of age in an endemic village in Egypt. Four tests were evaluated; a standardized clinical examination, night blood examinations for microfilariae (50 microL thick films and 1 mL membrane filtration), and a test for circulating filarial antigen. 191 subjects (44.75%) had at least one positive test and were considered to have filariasis. The sensitivities of clinical examination, thick films, membrane filtration and antigen testing for filariasis were 16%, 50%, 64%, and 88%, respectively. Relative to membrane filtration of night blood, the filarial antigen test had a sensitivity of 97.5%, a positive predictive power of 71%, and a negative predictive power of 99%. None of the blood tests was a sensitive indicator of clinical filariasis; 69% of clinical cases were negative in all 3 blood tests and would have been missed if clinical examinations had not been done. Therefore, we recommend a combination of clinical examination and the filarial antigen test (with optional examination for microfilariae of those with positive antigen tests) for community diagnosis of Bancroftian filariasis in endemic areas.
PubMed: 8296366
Affiliations:
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Le document en format XML
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<term>Aged</term>
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<term>Child</term>
<term>Egypt (epidemiology)</term>
<term>Elephantiasis, Filarial (diagnosis)</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
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<term>Predictive Value of Tests</term>
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<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Antigènes d'helminthe (analyse)</term>
<term>Enfant</term>
<term>Femelle</term>
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<term>Filariose lymphatique (épidémiologie)</term>
<term>Humains</term>
<term>Mâle</term>
<term>Prévalence</term>
<term>Sensibilité et spécificité</term>
<term>Sujet âgé</term>
<term>Valeur prédictive des tests</term>
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<term>Wuchereria bancrofti (isolement et purification)</term>
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<term>Aged</term>
<term>Animals</term>
<term>Child</term>
<term>Female</term>
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<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Prevalence</term>
<term>Sensitivity and Specificity</term>
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<term>Adulte d'âge moyen</term>
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<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
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<term>Sensibilité et spécificité</term>
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<front><div type="abstract" xml:lang="en">The objective of this study was to find the best tests for efficiently estimating the true prevalence of Bancroftian filariasis in endemic areas. The study population comprised 427 people over 10 years of age in an endemic village in Egypt. Four tests were evaluated; a standardized clinical examination, night blood examinations for microfilariae (50 microL thick films and 1 mL membrane filtration), and a test for circulating filarial antigen. 191 subjects (44.75%) had at least one positive test and were considered to have filariasis. The sensitivities of clinical examination, thick films, membrane filtration and antigen testing for filariasis were 16%, 50%, 64%, and 88%, respectively. Relative to membrane filtration of night blood, the filarial antigen test had a sensitivity of 97.5%, a positive predictive power of 71%, and a negative predictive power of 99%. None of the blood tests was a sensitive indicator of clinical filariasis; 69% of clinical cases were negative in all 3 blood tests and would have been missed if clinical examinations had not been done. Therefore, we recommend a combination of clinical examination and the filarial antigen test (with optional examination for microfilariae of those with positive antigen tests) for community diagnosis of Bancroftian filariasis in endemic areas.</div>
</front>
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<name sortKey="Weil, G J" sort="Weil, G J" uniqKey="Weil G" first="G J" last="Weil">G J Weil</name>
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