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Ivermectin 400 micrograms/kg: long-term suppression of microfilariae in Bancroftian filariasis.

Identifieur interne : 012C72 ( Main/Exploration ); précédent : 012C71; suivant : 012C73

Ivermectin 400 micrograms/kg: long-term suppression of microfilariae in Bancroftian filariasis.

Auteurs : J P Moulia-Pelat ; P. Glaziou ; L N Nguyen ; S. Chanteau ; R. Plichart ; I. Beylier ; P M Martin ; J L Cartel

Source :

Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]

RBID : pubmed:8153984

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Calendrier d'administration des médicaments, Facteurs temps, Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (administration et posologie), Ivermectine (usage thérapeutique), Porteur sain (traitement médicamenteux), Récidive, Wuchereria bancrofti.
MESH :
- administration et posologie : Ivermectine.
- traitement médicamenteux : Filariose lymphatique, Porteur sain.
- usage thérapeutique : Ivermectine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Calendrier d'administration des médicaments, Facteurs temps, Humains, Récidive, Wuchereria bancrofti.

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Carrier State (drug therapy), Drug Administration Schedule, Elephantiasis, Filarial (drug therapy), Humans, Ivermectin (administration & dosage), Ivermectin (therapeutic use), Middle Aged, Recurrence, Time Factors, Wuchereria bancrofti.
MESH :
- chemical , administration & dosage : Ivermectin.
- drug therapy : Carrier State, Elephantiasis, Filarial.
- chemical , therapeutic use : Ivermectin.
- Adolescent, Adult, Animals, Drug Administration Schedule, Humans, Middle Aged, Recurrence, Time Factors, Wuchereria bancrofti.

Abstract

Forty-three Wuchereria bancrofti carriers were given 4 successive semi-annual single doses of ivermectin 100 micrograms/kg (IVER 100). The geometric mean microfilaremia (mf) recurrence percentages, compared to the pre-initial treatment mf level, were 35%, 21%, 17% and 17% at 6, 12, 18 and 24 months respectively. However, the recurrence of mf 6 months after the fourth treatment remained high in 15 individuals, considered as 'bad responders'. At month 24, the subjects were randomly allocated into 2 groups: the first group was treated with a fifth dose of IVER 100 and the second with a first, single dose of 400 micrograms/kg of ivermectin (IVER 400). At month 30, the mf recurrence percentage was significantly higher in patients treated with IVER 100 than in those receiving IVER 400 (61% vs. 8%, P < 0.05). In the IVER 100 group, 6 of the 8 'bad responders' remained 'bad responders', whereas only 2 of 7 did so in the IVER 400 group. Only 3 additional patients in the IVER 100 group became consistently amicrofilaraemic, whereas 9 did so in the IVER 400 group. Two 'good responders' in the IVER 100 group became 'bad responders'. A single dose of 400 micrograms/kg of ivermectin has been demonstrated to be efficient for the treatment of carriers refractory to repeated doses of 100 micrograms/kg and to result in better long-term mf suppression. These results suggest a possible effect of 400 micrograms/kg of ivermectin on macrofilaria.

PubMed: 8153984

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Forty-three Wuchereria bancrofti carriers were given 4 successive semi-annual single doses of ivermectin 100 micrograms/kg (IVER 100). The geometric mean microfilaremia (mf) recurrence percentages, compared to the pre-initial treatment mf level, were 35%, 21%, 17% and 17% at 6, 12, 18 and 24 months respectively. However, the recurrence of mf 6 months after the fourth treatment remained high in 15 individuals, considered as 'bad responders'. At month 24, the subjects were randomly allocated into 2 groups: the first group was treated with a fifth dose of IVER 100 and the second with a first, single dose of 400 micrograms/kg of ivermectin (IVER 400). At month 30, the mf recurrence percentage was significantly higher in patients treated with IVER 100 than in those receiving IVER 400 (61% vs. 8%, P < 0.05). In the IVER 100 group, 6 of the 8 'bad responders' remained 'bad responders', whereas only 2 of 7 did so in the IVER 400 group. Only 3 additional patients in the IVER 100 group became consistently amicrofilaraemic, whereas 9 did so in the IVER 400 group. Two 'good responders' in the IVER 100 group became 'bad responders'. A single dose of 400 micrograms/kg of ivermectin has been demonstrated to be efficient for the treatment of carriers refractory to repeated doses of 100 micrograms/kg and to result in better long-term mf suppression. These results suggest a possible effect of 400 micrograms/kg of ivermectin on macrofilaria.</div>
</front>
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Ivermectin 400 micrograms/kg: long-term suppression of microfilariae in Bancroftian filariasis.

Ivermectin 400 micrograms/kg: long-term suppression of microfilariae in Bancroftian filariasis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

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