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[Significance of cutaneous microangiopathy for the pathogenesis of dermatitis in venous congestion due to chronic venous insufficiency].

Identifieur interne : 00C772 ( Main/Exploration ); précédent : 00C771; suivant : 00C773

[Significance of cutaneous microangiopathy for the pathogenesis of dermatitis in venous congestion due to chronic venous insufficiency].

Auteurs : M. Jünger [Allemagne] ; U. Hahn ; S. Bort ; T. Klyscz ; M. Hahn ; G. Rassner

Source :

RBID : pubmed:7856186

Descripteurs français

English descriptors

Abstract

Skin damage due to chronic venous insufficiency is preceded by severe microangiopathy of skin. With increasing clinical symptoms like edema, hyperpigmentation, induration, ulcer and atrophy blanche number of nutritive capillaries and transcutaneous oxygen-tension decreases, transcapillary, and interstitial leakage increases and cutaneous vascular reserve disappears. These congruent results were found by means of capillaroscopy, fluorescence-videomicroscopy, transcutaneously measured oxygen partial pressure and Laser Doppler Fluxmetry. Most of capillaries are elongated and tortuous, especially in ulcer stage they look glomerular. Compared to pin-shaped capillaries glomerular capillaries contribute less to nutrition because of functional AV-shunts. As dilated capillaries are already seen in skin areas without any trophic skin changes, cutaneous microangiopathy seems to be first consequence of venous hemodynamic disturbances which then is followed by skin disease. As severe microangiopathy still remains after healing of ulcer, it explains frequent recurrencies.

PubMed: 7856186


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Le document en format XML

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<term>Blood Flow Velocity (physiology)</term>
<term>Capillaries (pathology)</term>
<term>Capillary Permeability (physiology)</term>
<term>Dermatitis (pathology)</term>
<term>Dermatitis (physiopathology)</term>
<term>Humans</term>
<term>Lymphedema (pathology)</term>
<term>Lymphedema (physiopathology)</term>
<term>Oxygen Consumption (physiology)</term>
<term>Postphlebitic Syndrome (pathology)</term>
<term>Postphlebitic Syndrome (physiopathology)</term>
<term>Skin (blood supply)</term>
<term>Varicose Ulcer (pathology)</term>
<term>Varicose Ulcer (physiopathology)</term>
<term>Venous Insufficiency (pathology)</term>
<term>Venous Insufficiency (physiopathology)</term>
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<term>Consommation d'oxygène (physiologie)</term>
<term>Dermatite (anatomopathologie)</term>
<term>Dermatite (physiopathologie)</term>
<term>Humains</term>
<term>Insuffisance veineuse (anatomopathologie)</term>
<term>Insuffisance veineuse (physiopathologie)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Peau ()</term>
<term>Perméabilité capillaire (physiologie)</term>
<term>Syndrome post-phlébitique (anatomopathologie)</term>
<term>Syndrome post-phlébitique (physiopathologie)</term>
<term>Ulcère variqueux (anatomopathologie)</term>
<term>Ulcère variqueux (physiopathologie)</term>
<term>Vaisseaux capillaires (anatomopathologie)</term>
<term>Vitesse du flux sanguin (physiologie)</term>
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<term>Dermatite</term>
<term>Insuffisance veineuse</term>
<term>Lymphoedème</term>
<term>Syndrome post-phlébitique</term>
<term>Ulcère variqueux</term>
<term>Vaisseaux capillaires</term>
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<term>Skin</term>
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<term>Capillaries</term>
<term>Dermatitis</term>
<term>Lymphedema</term>
<term>Postphlebitic Syndrome</term>
<term>Varicose Ulcer</term>
<term>Venous Insufficiency</term>
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<term>Syndrome post-phlébitique</term>
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<div type="abstract" xml:lang="en">Skin damage due to chronic venous insufficiency is preceded by severe microangiopathy of skin. With increasing clinical symptoms like edema, hyperpigmentation, induration, ulcer and atrophy blanche number of nutritive capillaries and transcutaneous oxygen-tension decreases, transcapillary, and interstitial leakage increases and cutaneous vascular reserve disappears. These congruent results were found by means of capillaroscopy, fluorescence-videomicroscopy, transcutaneously measured oxygen partial pressure and Laser Doppler Fluxmetry. Most of capillaries are elongated and tortuous, especially in ulcer stage they look glomerular. Compared to pin-shaped capillaries glomerular capillaries contribute less to nutrition because of functional AV-shunts. As dilated capillaries are already seen in skin areas without any trophic skin changes, cutaneous microangiopathy seems to be first consequence of venous hemodynamic disturbances which then is followed by skin disease. As severe microangiopathy still remains after healing of ulcer, it explains frequent recurrencies.</div>
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