Heightened anti-filarial immune responsiveness in a Haitian pediatric population.
Identifieur interne : 00DE47 ( Main/Exploration ); précédent : 00DE46; suivant : 00DE48Heightened anti-filarial immune responsiveness in a Haitian pediatric population.
Auteurs : W L Hitch [États-Unis] ; P J Lammie ; M L EberhardSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1989.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (analyse), Brugia (immunologie), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Filariose lymphatique (immunologie), Filarioses (immunologie), Haïti, Humains, Immunoglobuline E (analyse), Immunoglobuline G (analyse), Microfilaria (immunologie), Mâle, Nourrisson, Études transversales.
- MESH :
- analyse : Anticorps antihelminthe, Immunoglobuline E, Immunoglobuline G.
- immunologie : Brugia, Filariose lymphatique, Filarioses, Microfilaria.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Haïti, Humains, Mâle, Nourrisson, Études transversales.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Animals, Antibodies, Helminth (analysis), Brugia (immunology), Child, Child, Preschool, Cross-Sectional Studies, Elephantiasis, Filarial (immunology), Female, Filariasis (immunology), Haiti, Humans, Immunoglobulin E (analysis), Immunoglobulin G (analysis), Infant, Male, Microfilariae (immunology), Middle Aged.
- MESH :
- chemical , analysis : Antibodies, Helminth, Immunoglobulin E, Immunoglobulin G.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Microfilariae.
- Adolescent, Adult, Age Factors, Animals, Child, Child, Preschool, Cross-Sectional Studies, Female, Haiti, Humans, Infant, Male, Middle Aged.
Abstract
The immunological consequences of exposure to filarial infection were examined by cross-sectional serological studies. Serum samples from 121 pediatric patients (18 months-15 years of age) were analyzed in parallel with a panel of sera from adults residing in the same area of Haiti. Parasite antigen specific IgG and IgE levels were determined by ELISA. IgG levels in children were significantly elevated in humoral immunoreactivity to Brugia pahangi extracts compared to adults. In addition, anti-filarial IgG levels in amicrofilaremic children were significantly greater than in microfilaremic children. In contrast, IgG levels in adults were equivalent independent of microfilaremic status. Anti-filarial IgE levels in sera from both children and adults were low in comparison to that of a subject with tropical pulmonary eosinophilia and were unrelated to clinical status. No correlations were found between humoral responses and age, sex, or degree of parasitemia. Sera from amicrofilaremic children and, to a lesser extent, adults recognize more antigens, particularly those of high molecular weight (greater than 55 kDa), than sera from microfilaremic patients.
PubMed: 2641643
Affiliations:
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sortKey="Hitch, W L" sort="Hitch, W L" uniqKey="Hitch W" first="W L" last="Hitch">W L Hitch</name><affiliation wicri:level="2"><nlm:affiliation>Tulane University, New Orleans, Louisiana.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>Tulane University, New Orleans</wicri:cityArea></affiliation></author><author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name></author><author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Brugia (immunology)</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Filariasis (immunology)</term><term>Haiti</term><term>Humans</term><term>Immunoglobulin E (analysis)</term><term>Immunoglobulin G (analysis)</term><term>Infant</term><term>Male</term><term>Microfilariae (immunology)</term><term>Middle Aged</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (analyse)</term><term>Brugia (immunologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Haïti</term><term>Humains</term><term>Immunoglobuline E (analyse)</term><term>Immunoglobuline G (analyse)</term><term>Microfilaria (immunologie)</term><term>Mâle</term><term>Nourrisson</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin E</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline E</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Microfilaria</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Microfilariae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Female</term><term>Haiti</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Haïti</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The immunological consequences of exposure to filarial infection were examined by cross-sectional serological studies. Serum samples from 121 pediatric patients (18 months-15 years of age) were analyzed in parallel with a panel of sera from adults residing in the same area of Haiti. Parasite antigen specific IgG and IgE levels were determined by ELISA. IgG levels in children were significantly elevated in humoral immunoreactivity to Brugia pahangi extracts compared to adults. In addition, anti-filarial IgG levels in amicrofilaremic children were significantly greater than in microfilaremic children. In contrast, IgG levels in adults were equivalent independent of microfilaremic status. Anti-filarial IgE levels in sera from both children and adults were low in comparison to that of a subject with tropical pulmonary eosinophilia and were unrelated to clinical status. No correlations were found between humoral responses and age, sex, or degree of parasitemia. Sera from amicrofilaremic children and, to a lesser extent, adults recognize more antigens, particularly those of high molecular weight (greater than 55 kDa), than sera from microfilaremic patients.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Louisiane</li></region></list><tree><noCountry><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name></noCountry><country name="États-Unis"><region name="Louisiane"><name sortKey="Hitch, W L" sort="Hitch, W L" uniqKey="Hitch W" first="W L" last="Hitch">W L Hitch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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