Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells.
Identifieur interne : 002C55 ( Main/Exploration ); précédent : 002C54; suivant : 002C56Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells.
Auteurs : Takayuki Kimura [Japon] ; Tatsuo S. Hamazaki [Japon] ; Makoto Sugaya [Japon] ; Shoji Fukuda [Japon] ; Techuan Chan [Japon] ; Miwa Tamura-Nakano [Japon] ; Shinichi Sato [Japon] ; Hitoshi Okochi [Japon]Source :
- Journal of dermatological science [ 1873-569X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Cellules endothéliales (), Endothélium lymphatique (), Humains, Inhibiteurs de la phosphodiestérase-3 (pharmacologie), Inhibiteurs de la phosphodiestérase-3 (usage thérapeutique), Lymphangiogenèse (), Lymphoedème (traitement médicamenteux), Modèles animaux de maladie humaine, Mouvement cellulaire (), Prolifération cellulaire (), Souris, Souris transgéniques, Tétrazoles (pharmacologie), Tétrazoles (usage thérapeutique), Évaluation préclinique de médicament.
- MESH :
- pharmacologie : Inhibiteurs de la phosphodiestérase-3, Tétrazoles.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : Inhibiteurs de la phosphodiestérase-3, Tétrazoles.
- Animaux, Cellules cultivées, Cellules endothéliales, Endothélium lymphatique, Humains, Lymphangiogenèse, Modèles animaux de maladie humaine, Mouvement cellulaire, Prolifération cellulaire, Souris, Souris transgéniques, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Cell Movement (drug effects), Cell Proliferation (drug effects), Cells, Cultured, Disease Models, Animal, Drug Evaluation, Preclinical, Endothelial Cells (drug effects), Endothelium, Lymphatic (drug effects), Humans, Lymphangiogenesis (drug effects), Lymphedema (drug therapy), Mice, Mice, Transgenic, Phosphodiesterase 3 Inhibitors (pharmacology), Phosphodiesterase 3 Inhibitors (therapeutic use), Tetrazoles (pharmacology), Tetrazoles (therapeutic use).
- MESH :
- chemical , pharmacology : Phosphodiesterase 3 Inhibitors, Tetrazoles.
- drug effects : Cell Movement, Cell Proliferation, Endothelial Cells, Endothelium, Lymphatic, Lymphangiogenesis.
- drug therapy : Lymphedema.
- chemical , therapeutic use : Phosphodiesterase 3 Inhibitors, Tetrazoles.
- Animals, Cells, Cultured, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Mice, Mice, Transgenic.
Abstract
Cilostazol, an inhibitor of phosphodiesterase type III, is an antiplatelet agent and vasodilator. Some clinical reports have suggested that this drug can improve progressive and refractory lymphedema.
DOI: 10.1016/j.jdermsci.2014.01.001
PubMed: 24517869
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Movement (drug effects)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Cells, Cultured</term>
<term>Disease Models, Animal</term>
<term>Drug Evaluation, Preclinical</term>
<term>Endothelial Cells (drug effects)</term>
<term>Endothelium, Lymphatic (drug effects)</term>
<term>Humans</term>
<term>Lymphangiogenesis (drug effects)</term>
<term>Lymphedema (drug therapy)</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Phosphodiesterase 3 Inhibitors (pharmacology)</term>
<term>Phosphodiesterase 3 Inhibitors (therapeutic use)</term>
<term>Tetrazoles (pharmacology)</term>
<term>Tetrazoles (therapeutic use)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cellules endothéliales ()</term>
<term>Endothélium lymphatique ()</term>
<term>Humains</term>
<term>Inhibiteurs de la phosphodiestérase-3 (pharmacologie)</term>
<term>Inhibiteurs de la phosphodiestérase-3 (usage thérapeutique)</term>
<term>Lymphangiogenèse ()</term>
<term>Lymphoedème (traitement médicamenteux)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mouvement cellulaire ()</term>
<term>Prolifération cellulaire ()</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Tétrazoles (pharmacologie)</term>
<term>Tétrazoles (usage thérapeutique)</term>
<term>Évaluation préclinique de médicament</term>
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<term>Tetrazoles</term>
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<term>Cell Proliferation</term>
<term>Endothelial Cells</term>
<term>Endothelium, Lymphatic</term>
<term>Lymphangiogenesis</term>
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<term>Tetrazoles</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de la phosphodiestérase-3</term>
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<term>Cells, Cultured</term>
<term>Disease Models, Animal</term>
<term>Drug Evaluation, Preclinical</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cellules endothéliales</term>
<term>Endothélium lymphatique</term>
<term>Humains</term>
<term>Lymphangiogenèse</term>
<term>Modèles animaux de maladie humaine</term>
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<term>Prolifération cellulaire</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Évaluation préclinique de médicament</term>
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<front><div type="abstract" xml:lang="en">Cilostazol, an inhibitor of phosphodiesterase type III, is an antiplatelet agent and vasodilator. Some clinical reports have suggested that this drug can improve progressive and refractory lymphedema.</div>
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