Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells.
Identifieur interne : 002C55 ( Main/Exploration ); précédent : 002C54; suivant : 002C56Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells.
Auteurs : Takayuki Kimura [Japon] ; Tatsuo S. Hamazaki [Japon] ; Makoto Sugaya [Japon] ; Shoji Fukuda [Japon] ; Techuan Chan [Japon] ; Miwa Tamura-Nakano [Japon] ; Shinichi Sato [Japon] ; Hitoshi Okochi [Japon]Source :
- Journal of dermatological science [ 1873-569X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Cellules endothéliales (), Endothélium lymphatique (), Humains, Inhibiteurs de la phosphodiestérase-3 (pharmacologie), Inhibiteurs de la phosphodiestérase-3 (usage thérapeutique), Lymphangiogenèse (), Lymphoedème (traitement médicamenteux), Modèles animaux de maladie humaine, Mouvement cellulaire (), Prolifération cellulaire (), Souris, Souris transgéniques, Tétrazoles (pharmacologie), Tétrazoles (usage thérapeutique), Évaluation préclinique de médicament.
- MESH :
- pharmacologie : Inhibiteurs de la phosphodiestérase-3, Tétrazoles.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : Inhibiteurs de la phosphodiestérase-3, Tétrazoles.
- Animaux, Cellules cultivées, Cellules endothéliales, Endothélium lymphatique, Humains, Lymphangiogenèse, Modèles animaux de maladie humaine, Mouvement cellulaire, Prolifération cellulaire, Souris, Souris transgéniques, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Cell Movement (drug effects), Cell Proliferation (drug effects), Cells, Cultured, Disease Models, Animal, Drug Evaluation, Preclinical, Endothelial Cells (drug effects), Endothelium, Lymphatic (drug effects), Humans, Lymphangiogenesis (drug effects), Lymphedema (drug therapy), Mice, Mice, Transgenic, Phosphodiesterase 3 Inhibitors (pharmacology), Phosphodiesterase 3 Inhibitors (therapeutic use), Tetrazoles (pharmacology), Tetrazoles (therapeutic use).
- MESH :
- chemical , pharmacology : Phosphodiesterase 3 Inhibitors, Tetrazoles.
- drug effects : Cell Movement, Cell Proliferation, Endothelial Cells, Endothelium, Lymphatic, Lymphangiogenesis.
- drug therapy : Lymphedema.
- chemical , therapeutic use : Phosphodiesterase 3 Inhibitors, Tetrazoles.
- Animals, Cells, Cultured, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Mice, Mice, Transgenic.
Abstract
Cilostazol, an inhibitor of phosphodiesterase type III, is an antiplatelet agent and vasodilator. Some clinical reports have suggested that this drug can improve progressive and refractory lymphedema.
DOI: 10.1016/j.jdermsci.2014.01.001
PubMed: 24517869
Affiliations:
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Le document en format XML
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Hamazaki</name><affiliation wicri:level="3"><nlm:affiliation>Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. 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Chan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tamura Nakano, Miwa" sort="Tamura Nakano, Miwa" uniqKey="Tamura Nakano M" first="Miwa" last="Tamura-Nakano">Miwa Tamura-Nakano</name><affiliation wicri:level="3"><nlm:affiliation>EM Support Unit, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>EM Support Unit, National Center for Global Health and Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sato, Shinichi" sort="Sato, Shinichi" uniqKey="Sato S" first="Shinichi" last="Sato">Shinichi Sato</name><affiliation wicri:level="4"><nlm:affiliation>Department of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region><settlement type="city">Tokyo</settlement></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Okochi, Hitoshi" sort="Okochi, Hitoshi" uniqKey="Okochi H" first="Hitoshi" last="Okochi">Hitoshi Okochi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Journal of dermatological science</title><idno type="eISSN">1873-569X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Movement (drug effects)</term><term>Cell Proliferation (drug effects)</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Drug Evaluation, Preclinical</term><term>Endothelial Cells (drug effects)</term><term>Endothelium, Lymphatic (drug effects)</term><term>Humans</term><term>Lymphangiogenesis (drug effects)</term><term>Lymphedema (drug therapy)</term><term>Mice</term><term>Mice, Transgenic</term><term>Phosphodiesterase 3 Inhibitors (pharmacology)</term><term>Phosphodiesterase 3 Inhibitors (therapeutic use)</term><term>Tetrazoles (pharmacology)</term><term>Tetrazoles (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cellules endothéliales ()</term><term>Endothélium lymphatique ()</term><term>Humains</term><term>Inhibiteurs de la phosphodiestérase-3 (pharmacologie)</term><term>Inhibiteurs de la phosphodiestérase-3 (usage thérapeutique)</term><term>Lymphangiogenèse ()</term><term>Lymphoedème (traitement médicamenteux)</term><term>Modèles animaux de maladie humaine</term><term>Mouvement cellulaire ()</term><term>Prolifération cellulaire ()</term><term>Souris</term><term>Souris transgéniques</term><term>Tétrazoles (pharmacologie)</term><term>Tétrazoles (usage thérapeutique)</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phosphodiesterase 3 Inhibitors</term><term>Tetrazoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Movement</term><term>Cell Proliferation</term><term>Endothelial Cells</term><term>Endothelium, Lymphatic</term><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Inhibiteurs de la phosphodiestérase-3</term><term>Tétrazoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Phosphodiesterase 3 Inhibitors</term><term>Tetrazoles</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de la phosphodiestérase-3</term><term>Tétrazoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cellules endothéliales</term><term>Endothélium lymphatique</term><term>Humains</term><term>Lymphangiogenèse</term><term>Modèles animaux de maladie humaine</term><term>Mouvement cellulaire</term><term>Prolifération cellulaire</term><term>Souris</term><term>Souris transgéniques</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cilostazol, an inhibitor of phosphodiesterase type III, is an antiplatelet agent and vasodilator. Some clinical reports have suggested that this drug can improve progressive and refractory lymphedema.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Kimura, Takayuki" sort="Kimura, Takayuki" uniqKey="Kimura T" first="Takayuki" last="Kimura">Takayuki Kimura</name></region><name sortKey="Chan, Techuan" sort="Chan, Techuan" uniqKey="Chan T" first="Techuan" last="Chan">Techuan Chan</name><name sortKey="Fukuda, Shoji" sort="Fukuda, Shoji" uniqKey="Fukuda S" first="Shoji" last="Fukuda">Shoji Fukuda</name><name sortKey="Hamazaki, Tatsuo S" sort="Hamazaki, Tatsuo S" uniqKey="Hamazaki T" first="Tatsuo S" last="Hamazaki">Tatsuo S. Hamazaki</name><name sortKey="Okochi, Hitoshi" sort="Okochi, Hitoshi" uniqKey="Okochi H" first="Hitoshi" last="Okochi">Hitoshi Okochi</name><name sortKey="Sato, Shinichi" sort="Sato, Shinichi" uniqKey="Sato S" first="Shinichi" last="Sato">Shinichi Sato</name><name sortKey="Sugaya, Makoto" sort="Sugaya, Makoto" uniqKey="Sugaya M" first="Makoto" last="Sugaya">Makoto Sugaya</name><name sortKey="Tamura Nakano, Miwa" sort="Tamura Nakano, Miwa" uniqKey="Tamura Nakano M" first="Miwa" last="Tamura-Nakano">Miwa Tamura-Nakano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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