Hereditary vascular anomalies: new insights into their pathogenesis.
Identifieur interne : 008793 ( Main/Exploration ); précédent : 008792; suivant : 008794Hereditary vascular anomalies: new insights into their pathogenesis.
Auteurs : J-C Tille [Suisse] ; M S PepperSource :
- Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Femelle, Humains, Hémangiome (anatomopathologie), Hémangiome (embryologie), Hémangiome (génétique), Lymphangiogenèse (génétique), Lymphoedème (), Lymphoedème (génétique), Malformations (embryologie), Malformations (génétique), Malformations artérioveineuses (anatomopathologie), Malformations artérioveineuses (embryologie), Malformations artérioveineuses (génétique), Mâle, Nouveau-né, Néovascularisation physiologique (génétique), Récepteur facteur croissance (génétique), Récepteur facteur croissance (physiologie), Rémission spontanée, Souris, Souris transgéniques, Substances de croissance (génétique), Substances de croissance (physiologie), Système lymphatique (malformations), Système lymphatique (métabolisme), Vaisseaux sanguins (embryologie), Vaisseaux sanguins (malformations).
- MESH :
- anatomopathologie : Hémangiome, Malformations artérioveineuses.
- embryologie : Hémangiome, Malformations, Malformations artérioveineuses, Vaisseaux sanguins.
- génétique : Hémangiome, Lymphangiogenèse, Lymphoedème, Malformations, Malformations artérioveineuses, Néovascularisation physiologique, Récepteur facteur croissance, Substances de croissance.
- malformations : Système lymphatique, Vaisseaux sanguins.
- métabolisme : Système lymphatique.
- physiologie : Récepteur facteur croissance, Substances de croissance.
- Animaux, Femelle, Humains, Lymphoedème, Mâle, Nouveau-né, Rémission spontanée, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Arteriovenous Malformations (embryology), Arteriovenous Malformations (genetics), Arteriovenous Malformations (pathology), Blood Vessels (abnormalities), Blood Vessels (embryology), Congenital Abnormalities (embryology), Congenital Abnormalities (genetics), Female, Growth Substances (genetics), Growth Substances (physiology), Hemangioma (embryology), Hemangioma (genetics), Hemangioma (pathology), Humans, Infant, Newborn, Lymphangiogenesis (genetics), Lymphatic System (abnormalities), Lymphatic System (metabolism), Lymphedema (classification), Lymphedema (genetics), Male, Mice, Mice, Transgenic, Neovascularization, Physiologic (genetics), Receptors, Growth Factor (genetics), Receptors, Growth Factor (physiology), Remission, Spontaneous.
- MESH :
- chemical , genetics : Growth Substances, Receptors, Growth Factor.
- abnormalities : Blood Vessels, Lymphatic System.
- classification : Lymphedema.
- embryology : Arteriovenous Malformations, Blood Vessels, Congenital Abnormalities, Hemangioma.
- genetics : Arteriovenous Malformations, Congenital Abnormalities, Hemangioma, Lymphangiogenesis, Lymphedema, Neovascularization, Physiologic.
- metabolism : Lymphatic System.
- pathology : Arteriovenous Malformations, Hemangioma.
- chemical , physiology : Growth Substances, Receptors, Growth Factor.
- Animals, Female, Humans, Infant, Newborn, Male, Mice, Mice, Transgenic, Remission, Spontaneous.
Abstract
Increased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.
DOI: 10.1161/01.ATV.0000137390.56554.df
PubMed: 15231518
Affiliations:
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Le document en format XML
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mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Pepper, M S" sort="Pepper, M S" uniqKey="Pepper M" first="M S" last="Pepper">M S Pepper</name></noCountry><country name="Suisse"><noRegion><name sortKey="Tille, J C" sort="Tille, J C" uniqKey="Tille J" first="J-C" last="Tille">J-C Tille</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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