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Aggressive simultaneous radiochemotherapy with cisplatin and paclitaxel in combination with accelerated hyperfractionated radiotherapy in locally advanced head and neck tumors. Results of a phase I-II trial.

Identifieur interne : 008F46 ( Main/Exploration ); précédent : 008F45; suivant : 008F47

Aggressive simultaneous radiochemotherapy with cisplatin and paclitaxel in combination with accelerated hyperfractionated radiotherapy in locally advanced head and neck tumors. Results of a phase I-II trial.

Auteurs : Thomas Kuhnt [Allemagne] ; Axel Becker ; Steffi Pigorsch ; Tanja Pelz ; Marc Bloching ; Marcus Passmann ; Erwin Lotterer ; Gabriele H Nsgen ; Jürgen Dunst

Source :

RBID : pubmed:14566475

Descripteurs français

English descriptors

Abstract

Simultaneous radiochemotherapy (sRCT) is the treatment of first choice in locally advanced head and neck cancers. We have tested a very aggressive combination protocol with cisplatin and escalated paclitaxel in combination with accelerated hyperfractionated radiotherapy to assess the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), overall toxicity, and response rate.

DOI: 10.1007/s00066-003-1106-0
PubMed: 14566475


Affiliations:


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Le document en format XML

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<front>
<div type="abstract" xml:lang="en">Simultaneous radiochemotherapy (sRCT) is the treatment of first choice in locally advanced head and neck cancers. We have tested a very aggressive combination protocol with cisplatin and escalated paclitaxel in combination with accelerated hyperfractionated radiotherapy to assess the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), overall toxicity, and response rate.</div>
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