Immunocytochemical localization of antigens recognized by asymptomatic microfilaremic patient's antisera in microfilariae of Wuchereria bancrofti.
Identifieur interne : 009A24 ( Main/Exploration ); précédent : 009A23; suivant : 009A25Immunocytochemical localization of antigens recognized by asymptomatic microfilaremic patient's antisera in microfilariae of Wuchereria bancrofti.
Auteurs : L C Alves [Brésil] ; F A Brayner ; L F Silva ; J. Miranda ; A. Rocha ; C A PeixotoSource :
- Parasitology research [ 0932-0113 ] ; 2001.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Antigènes d'helminthe.
- croissance et développement : Wuchereria bancrofti.
- immunologie : Anticorps antihelminthe, Filariose lymphatique, Microfilaria, Wuchereria bancrofti.
- Animaux, Humains, Immunohistochimie.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antigens, Helminth.
- chemical , immunology : Antibodies, Helminth.
- growth & development : Wuchereria bancrofti.
- immunology : Elephantiasis, Filarial, Microfilariae, Wuchereria bancrofti.
- Animals, Humans, Immunohistochemistry.
Abstract
Ultrathin sections of microfilariae of Wuchereria bancrofti embedded in hydrophilic resin were incubated with sera from patients, using antisera from asymptomatic microfilaremic patients with different microfilarial densities [1-100 microfilariae (mf)/ml, 101-500 mf/ml, > 1,000 mf/ml]. All groups studied showed reactivity against relevant epitopes in all tissues of microfilariae of W. bancrofti, instead of being localized in a specific nematode region, although the number of colloidal per square micron was inversely proportional to the microfilaremia. Such results confirm data obtained by other authors and indicate a possible role for the humoral response in the mechanism for the destruction of circulating microfilariae.
PubMed: 11763438
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Ultrathin sections of microfilariae of Wuchereria bancrofti embedded in hydrophilic resin were incubated with sera from patients, using antisera from asymptomatic microfilaremic patients with different microfilarial densities [1-100 microfilariae (mf)/ml, 101-500 mf/ml, > 1,000 mf/ml]. All groups studied showed reactivity against relevant epitopes in all tissues of microfilariae of W. bancrofti, instead of being localized in a specific nematode region, although the number of colloidal per square micron was inversely proportional to the microfilaremia. Such results confirm data obtained by other authors and indicate a possible role for the humoral response in the mechanism for the destruction of circulating microfilariae.</div>
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