LymphedemaV1, Main, Exploration, bibRecordById, Pascal:86-0241196

The inheritance of primary lymphoedema.

Identifieur interne : 00EE76 ( Main/Exploration ); précédent : 00EE75; suivant : 00EE77

The inheritance of primary lymphoedema.

Auteurs : R F Dale

Source :

Journal of Medical Genetics [ 0022-2593 ] ; 1985-08.

RBID : ISTEX:36263F315444999D73274D470A2E736EF55319EE

Descripteurs français

KwdFr :
- Détection d'hétérozygote, Facteurs de l'âge, Facteurs sexuels, Femelle, Gènes dominants, Humains, Lymphoedème (génétique), Mâle, Pedigree.
MESH :
- génétique : Lymphoedème.
Pascal (Inist)
- Appareil circulatoire pathologie, Détection d'hétérozygote, Déterminisme génétique, Etude familiale, Facteurs de l'âge, Facteurs sexuels, Femelle, Gènes dominants, Homme, Humains, Lymphoedème, Mâle, Pedigree, Primaire, Système lymphatique.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Age Factors, Cardiovascular disease, Family study, Female, Genes, Dominant, Heterozygote Detection, Human, Humans, Inheritance, Lymphatic system, Lymphedema, Lymphedema (genetics), Male, Pedigree, Primary, Sex Factors.
MESH :
- genetics : Lymphedema.
- Age Factors, Female, Genes, Dominant, Heterozygote Detection, Humans, Male, Pedigree, Sex Factors.

Abstract

A family study is reported on 312 index patients who had primary lymphoedema with onset before 36 years. All had been investigated at St Thomas's Hospital, London, between 1965 and 1980. Most of the information was obtained by questionnaire, but 70 patients were also interviewed to check the reliability of the answers to the questionnaire. The frequency at birth of those who will develop primary lymphoedema is estimated to be about 1 in 6000, with a sex ratio of about one male to three females. Approximately 10% of children of index patients and 10% of sibs were affected when these relatives were at least five years older than the age of onset in the index patient. The proportion of female relatives affected was between two and four times that of males affected. The proportion of parents affected was about 10%. The proportion of grandparents, aunts, and uncles was about 2.5%. Where the index patient had an affected parent, the proportion affected of sibs and children was about 20%. The risk to relatives of male index patients was about 50% higher than for female index patients.

Url:

DOI: 10.1136/jmg.22.4.274

Affiliations:

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<front><div type="abstract" xml:lang="en">A family study is reported on 312 index patients who had primary lymphoedema with onset before 36 years. All had been investigated at St Thomas's Hospital, London, between 1965 and 1980. Most of the information was obtained by questionnaire, but 70 patients were also interviewed to check the reliability of the answers to the questionnaire. The frequency at birth of those who will develop primary lymphoedema is estimated to be about 1 in 6000, with a sex ratio of about one male to three females. Approximately 10% of children of index patients and 10% of sibs were affected when these relatives were at least five years older than the age of onset in the index patient. The proportion of female relatives affected was between two and four times that of males affected. The proportion of parents affected was about 10%. The proportion of grandparents, aunts, and uncles was about 2.5%. Where the index patient had an affected parent, the proportion affected of sibs and children was about 20%. The risk to relatives of male index patients was about 50% higher than for female index patients.</div>
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Serveur d'exploration sur le lymphœdème

The inheritance of primary lymphoedema.

The inheritance of primary lymphoedema.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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