Elevated D-dimer Level is Diagnostic for Venous Malformations
Identifieur interne : 006312 ( Main/Exploration ); précédent : 006311; suivant : 006313Elevated D-dimer Level is Diagnostic for Venous Malformations
Auteurs : Anne Dompmartin [France] ; Fanny Ballieux [Belgique] ; Pascal Thibon [France] ; Agnès Lequerrec [France] ; Cédric Hermans [Belgique] ; Philippe Clapuyt [Belgique] ; Marie-Thérèse Barrellier [France] ; Franck Hammer [Belgique] ; Daniel Labbé [France] ; Miikka Vikkula [Belgique] ; Laurence M. Boon [Belgique]Source :
- Archives of dermatology [ 0003-987X ] ; 2009.
Abstract
Differential diagnosis of vascular malformations can be problematic even in specialized interdisciplinary centers. Localized Intravascular Coagulopathy, characterized by elevated D-dimer levels, has been observed in about 40% of patients with venous malformations. We evaluated if this is specific for them, and thus useful for differential diagnosis.
Prospective convenience sample accrued from 2 interdisciplinary sites in Brussels, Belgium and Caen, France.
The study population comprised 280 patients with clinical data, Doppler ultrasound (for 251 patients) and coagulation parameters.
Measurement of D-dimer levels.
A venous malformation was diagnosed in 69,6% (n=195/280) of patients, and 83 of them had elevated D-dimer levels; the sensitivity of D-dimer dosage was 42.6% [95%CI: 35.6%–49.5%]. Among the 85 patients without venous malformation, D-dimer levels were elevated only in 3 patients; the specificity of the dosage was 96.5% [95%CI: 92.5%–100%].
Elevated D-dimer level is highly specific for venous malformations (pure, combined or syndromic), and therefore, this easy and cheap biomarker test should become part of the clinical evaluation of vascular anomalies. It can detect hidden venous malformations and help differentiate glomuvenous malformation (normal D-dimer levels) from other multifocal venous lesions. Elevated D-dimer level also differentiates a venous malformation from a lymphatic malformation. Moreover, slow-flow Klippel-Trenaunay syndrome (capillaro-lymphatico-
Url:
DOI: 10.1001/archdermatol.2009.296
PubMed: 19917952
PubMed Central: 5561655
Affiliations:
- Belgique, France
- Basse-Normandie, Province du Brabant wallon, Région Normandie, Région wallonne
- Caen, Louvain-la-Neuve
- Université catholique de Louvain, Université de Caen Basse-Normandie
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<author><name sortKey="Lequerrec, Agnes" sort="Lequerrec, Agnes" uniqKey="Lequerrec A" first="Agnès" last="Lequerrec">Agnès Lequerrec</name>
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<author><name sortKey="Hermans, Cedric" sort="Hermans, Cedric" uniqKey="Hermans C" first="Cédric" last="Hermans">Cédric Hermans</name>
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<author><name sortKey="Clapuyt, Philippe" sort="Clapuyt, Philippe" uniqKey="Clapuyt P" first="Philippe" last="Clapuyt">Philippe Clapuyt</name>
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<author><name sortKey="Hammer, Franck" sort="Hammer, Franck" uniqKey="Hammer F" first="Franck" last="Hammer">Franck Hammer</name>
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<author><name sortKey="Labbe, Daniel" sort="Labbe, Daniel" uniqKey="Labbe D" first="Daniel" last="Labbé">Daniel Labbé</name>
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<author><name sortKey="Vikkula, Miikka" sort="Vikkula, Miikka" uniqKey="Vikkula M" first="Miikka" last="Vikkula">Miikka Vikkula</name>
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<author><name sortKey="Boon, Laurence M" sort="Boon, Laurence M" uniqKey="Boon L" first="Laurence M" last="Boon">Laurence M. Boon</name>
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<orgName type="university">Université catholique de Louvain</orgName>
<country>Belgique</country>
<placeName><settlement type="city">Louvain-la-Neuve</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province du Brabant wallon</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A8">Laboratory of Human Molecular Genetics, Université catholique de Louvain, de Duve Institute, B-1200 Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Human Molecular Genetics, Université catholique de Louvain, de Duve Institute, B-1200 Brussels</wicri:regionArea>
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<series><title level="j">Archives of dermatology</title>
<idno type="ISSN">0003-987X</idno>
<idno type="eISSN">1538-3652</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Differential diagnosis of vascular malformations can be problematic even in specialized interdisciplinary centers. Localized Intravascular Coagulopathy, characterized by elevated D-dimer levels, has been observed in about 40% of patients with venous malformations. We evaluated if this is specific for them, and thus useful for differential diagnosis.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">Prospective convenience sample accrued from 2 interdisciplinary sites in Brussels, Belgium and Caen, France.</p>
</sec>
<sec id="S3"><title>Participants</title>
<p id="P3">The study population comprised 280 patients with clinical data, Doppler ultrasound (for 251 patients) and coagulation parameters.</p>
</sec>
<sec id="S4"><title>Main outcome measure</title>
<p id="P4">Measurement of D-dimer levels.</p>
</sec>
<sec id="S5"><title>Results</title>
<p id="P5">A venous malformation was diagnosed in 69,6% (n=195/280) of patients, and 83 of them had elevated D-dimer levels; the sensitivity of D-dimer dosage was 42.6% [95%CI: 35.6%–49.5%]. Among the 85 patients without venous malformation, D-dimer levels were elevated only in 3 patients; the specificity of the dosage was 96.5% [95%CI: 92.5%–100%].</p>
</sec>
<sec id="S6"><title>Conclusions</title>
<p id="P6">Elevated D-dimer level is highly specific for venous malformations (pure, combined or syndromic), and therefore, this easy and cheap biomarker test should become part of the clinical evaluation of vascular anomalies. It can detect hidden venous malformations and help differentiate glomuvenous malformation (normal D-dimer levels) from other multifocal venous lesions. Elevated D-dimer level also differentiates a venous malformation from a lymphatic malformation. Moreover, slow-flow Klippel-Trenaunay syndrome (capillaro-lymphatico-<italic>venous</italic>
malformation with limb hypertrophy) can be distinguished from fast-flow Parkes Weber syndrome (capillary malformation with underlying multiple microfistulas and limb hypertrophy). For these reasons, D-dimer level measurement is a useful complementary tool for diagnosing vascular anomalies in everyday practice.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>France</li>
</country>
<region><li>Basse-Normandie</li>
<li>Province du Brabant wallon</li>
<li>Région Normandie</li>
<li>Région wallonne</li>
</region>
<settlement><li>Caen</li>
<li>Louvain-la-Neuve</li>
</settlement>
<orgName><li>Université catholique de Louvain</li>
<li>Université de Caen Basse-Normandie</li>
</orgName>
</list>
<tree><country name="France"><region name="Région Normandie"><name sortKey="Dompmartin, Anne" sort="Dompmartin, Anne" uniqKey="Dompmartin A" first="Anne" last="Dompmartin">Anne Dompmartin</name>
</region>
<name sortKey="Barrellier, Marie Therese" sort="Barrellier, Marie Therese" uniqKey="Barrellier M" first="Marie-Thérèse" last="Barrellier">Marie-Thérèse Barrellier</name>
<name sortKey="Labbe, Daniel" sort="Labbe, Daniel" uniqKey="Labbe D" first="Daniel" last="Labbé">Daniel Labbé</name>
<name sortKey="Lequerrec, Agnes" sort="Lequerrec, Agnes" uniqKey="Lequerrec A" first="Agnès" last="Lequerrec">Agnès Lequerrec</name>
<name sortKey="Thibon, Pascal" sort="Thibon, Pascal" uniqKey="Thibon P" first="Pascal" last="Thibon">Pascal Thibon</name>
</country>
<country name="Belgique"><region name="Région wallonne"><name sortKey="Ballieux, Fanny" sort="Ballieux, Fanny" uniqKey="Ballieux F" first="Fanny" last="Ballieux">Fanny Ballieux</name>
</region>
<name sortKey="Boon, Laurence M" sort="Boon, Laurence M" uniqKey="Boon L" first="Laurence M" last="Boon">Laurence M. Boon</name>
<name sortKey="Boon, Laurence M" sort="Boon, Laurence M" uniqKey="Boon L" first="Laurence M" last="Boon">Laurence M. Boon</name>
<name sortKey="Clapuyt, Philippe" sort="Clapuyt, Philippe" uniqKey="Clapuyt P" first="Philippe" last="Clapuyt">Philippe Clapuyt</name>
<name sortKey="Hammer, Franck" sort="Hammer, Franck" uniqKey="Hammer F" first="Franck" last="Hammer">Franck Hammer</name>
<name sortKey="Hermans, Cedric" sort="Hermans, Cedric" uniqKey="Hermans C" first="Cédric" last="Hermans">Cédric Hermans</name>
<name sortKey="Vikkula, Miikka" sort="Vikkula, Miikka" uniqKey="Vikkula M" first="Miikka" last="Vikkula">Miikka Vikkula</name>
</country>
</tree>
</affiliations>
</record>
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