Quality of life and sexuality in disease-free survivors of cervical cancer after radical hysterectomy alone
Identifieur interne : 000C08 ( Main/Exploration ); précédent : 000C07; suivant : 000C09Quality of life and sexuality in disease-free survivors of cervical cancer after radical hysterectomy alone
Auteurs : Meizhu Xiao ; Huiqiao Gao ; Huimin Bai ; Zhenyu ZhangSource :
- Medicine [ 0025-7974 ] ; 2016.
Abstract
The aim of the present study was to evaluate the possible differences between total laparoscopy and laparotomy regarding their impact on postoperative quality of life and sexuality in disease-free cervical cancer survivors who received radical hysterectomy (RH) and/or lymphadenectomy alone and were followed for >1 year.
We reviewed all patients with cervical cancer who had received surgical treatment in our hospital between January 2001 and March 2014. Consecutive sexually active survivors who received RH and/or lymphadenectomy for early stage cervical cancer were enrolled and divided into 2 groups based on surgical approach. Survivors were interviewed and completed validated questionnaires, including the European Organization for Research Treatment of Cancer Quality-of-Life Core Questionnaire including 30 items, the Cervical Cancer-Specific Module of European Organization for Research Treatment of Cancer Quality-of-Life Questionnaire including 24 items (EORTC QLQ-CX24), and the Female Sexual Function Index (FSFI).
In total, 273 patients with histologically confirmed cervical cancer were retrospectively reviewed. However, only 64 patients had received RH and/or lymphadenectomy alone; 58 survivors meeting the inclusion criteria were enrolled, including 42 total laparoscopy cases and 16 laparotomy cases, with an average follow-up of 46.1 and 51.2 months, respectively. The survivors in the 2 groups obtained good and similar scores on all items of the European Organization for Research Treatment of Cancer Quality-of-Life Core Questionnaire including 30 items and Cervical Cancer-Specific Module of European Organization for Research Treatment of Cancer Quality-of-Life Questionnaire including 24 items, without significant differences after controlling for covariate background characteristics. To the date of submission, 21.4% (9/42) of cases in the total laparoscopy group and 31.2% (5/16) of cases in the laparotomy group had not resumed sexual behavior after RH. Additionally, the scores on the FSFI items were comparable between the 2 groups; however, the total FSFI scores were 19.7 and 17.4 for total laparoscopy and laparotomy survivors, respectively, both of which were less than the validated cutoff value of 26.6 for diagnosing female sexual dysfunction.
Disease-free cervical cancer survivors after RH and/or lymphadenectomy were able to cope well, although RH could greatly impair females’ sexual function regardless of surgical approach. Moreover, the long-term quality of life and sexual function of survivors seemed to be independent of the surgical approach chosen. Randomized controlled and longitudinal trials with larger populations are needed to better compare these issues between patients receiving laparoscopy and laparotomy.
Url:
DOI: 10.1097/MD.0000000000004787
PubMed: 27603383
PubMed Central: 5023906
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quality of life and sexuality in disease-free survivors of cervical cancer after radical hysterectomy alone</title><author><name sortKey="Xiao, Meizhu" sort="Xiao, Meizhu" uniqKey="Xiao M" first="Meizhu" last="Xiao">Meizhu Xiao</name></author><author><name sortKey="Gao, Huiqiao" sort="Gao, Huiqiao" uniqKey="Gao H" first="Huiqiao" last="Gao">Huiqiao Gao</name></author><author><name sortKey="Bai, Huimin" sort="Bai, Huimin" uniqKey="Bai H" first="Huimin" last="Bai">Huimin Bai</name></author><author><name sortKey="Zhang, Zhenyu" sort="Zhang, Zhenyu" uniqKey="Zhang Z" first="Zhenyu" last="Zhang">Zhenyu Zhang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27603383</idno><idno type="pmc">5023906</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023906</idno><idno type="RBID">PMC:5023906</idno><idno type="doi">10.1097/MD.0000000000004787</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">004197</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004197</idno><idno type="wicri:Area/Pmc/Curation">004196</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004196</idno><idno type="wicri:Area/Pmc/Checkpoint">000655</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000655</idno><idno type="wicri:Area/Ncbi/Merge">008776</idno><idno type="wicri:Area/Ncbi/Curation">008776</idno><idno type="wicri:Area/Ncbi/Checkpoint">008776</idno><idno type="wicri:doubleKey">0025-7974:2016:Xiao M:quality:of:life</idno><idno type="wicri:Area/Main/Merge">000C09</idno><idno type="wicri:Area/Main/Curation">000C08</idno><idno type="wicri:Area/Main/Exploration">000C08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Quality of life and sexuality in disease-free survivors of cervical cancer after radical hysterectomy alone</title><author><name sortKey="Xiao, Meizhu" sort="Xiao, Meizhu" uniqKey="Xiao M" first="Meizhu" last="Xiao">Meizhu Xiao</name></author><author><name sortKey="Gao, Huiqiao" sort="Gao, Huiqiao" uniqKey="Gao H" first="Huiqiao" last="Gao">Huiqiao Gao</name></author><author><name sortKey="Bai, Huimin" sort="Bai, Huimin" uniqKey="Bai H" first="Huimin" last="Bai">Huimin Bai</name></author><author><name sortKey="Zhang, Zhenyu" sort="Zhang, Zhenyu" uniqKey="Zhang Z" first="Zhenyu" last="Zhang">Zhenyu Zhang</name></author></analytic><series><title level="j">Medicine</title><idno type="ISSN">0025-7974</idno><idno type="eISSN">1536-5964</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The aim of the present study was to evaluate the possible differences between total laparoscopy and laparotomy regarding their impact on postoperative quality of life and sexuality in disease-free cervical cancer survivors who received radical hysterectomy (RH) and/or lymphadenectomy alone and were followed for >1 year.</p><p>We reviewed all patients with cervical cancer who had received surgical treatment in our hospital between January 2001 and March 2014. Consecutive sexually active survivors who received RH and/or lymphadenectomy for early stage cervical cancer were enrolled and divided into 2 groups based on surgical approach. Survivors were interviewed and completed validated questionnaires, including the European Organization for Research Treatment of Cancer Quality-of-Life Core Questionnaire including 30 items, the Cervical Cancer-Specific Module of European Organization for Research Treatment of Cancer Quality-of-Life Questionnaire including 24 items (EORTC QLQ-CX24), and the Female Sexual Function Index (FSFI).</p><p>In total, 273 patients with histologically confirmed cervical cancer were retrospectively reviewed. However, only 64 patients had received RH and/or lymphadenectomy alone; 58 survivors meeting the inclusion criteria were enrolled, including 42 total laparoscopy cases and 16 laparotomy cases, with an average follow-up of 46.1 and 51.2 months, respectively. The survivors in the 2 groups obtained good and similar scores on all items of the European Organization for Research Treatment of Cancer Quality-of-Life Core Questionnaire including 30 items and Cervical Cancer-Specific Module of European Organization for Research Treatment of Cancer Quality-of-Life Questionnaire including 24 items, without significant differences after controlling for covariate background characteristics. To the date of submission, 21.4% (9/42) of cases in the total laparoscopy group and 31.2% (5/16) of cases in the laparotomy group had not resumed sexual behavior after RH. Additionally, the scores on the FSFI items were comparable between the 2 groups; however, the total FSFI scores were 19.7 and 17.4 for total laparoscopy and laparotomy survivors, respectively, both of which were less than the validated cutoff value of 26.6 for diagnosing female sexual dysfunction.</p><p>Disease-free cervical cancer survivors after RH and/or lymphadenectomy were able to cope well, although RH could greatly impair females’ sexual function regardless of surgical approach. Moreover, the long-term quality of life and sexual function of survivors seemed to be independent of the surgical approach chosen. Randomized controlled and longitudinal trials with larger populations are needed to better compare these issues between patients receiving laparoscopy and laparotomy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Henry, Mk" uniqKey="Henry M">MK Henry</name></author><author><name sortKey="Brian, Nb" uniqKey="Brian N">NB Brian</name></author><author><name sortKey="Frederick, Bs" uniqKey="Frederick B">BS Frederick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieterse, Qd" uniqKey="Pieterse Q">QD Pieterse</name></author><author><name sortKey="Maas, Cp" uniqKey="Maas C">CP 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Möller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fabio, G" uniqKey="Fabio G">G Fabio</name></author><author><name sortKey="Antonella, C" uniqKey="Antonella C">C Antonella</name></author><author><name sortKey="Giuseppe, C" uniqKey="Giuseppe C">C Giuseppe</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bai, Huimin" sort="Bai, Huimin" uniqKey="Bai H" first="Huimin" last="Bai">Huimin Bai</name><name sortKey="Gao, Huiqiao" sort="Gao, Huiqiao" uniqKey="Gao H" first="Huiqiao" last="Gao">Huiqiao Gao</name><name sortKey="Xiao, Meizhu" sort="Xiao, Meizhu" uniqKey="Xiao M" first="Meizhu" last="Xiao">Meizhu Xiao</name><name sortKey="Zhang, Zhenyu" sort="Zhang, Zhenyu" uniqKey="Zhang Z" first="Zhenyu" last="Zhang">Zhenyu Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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