In the Era of Genomics, Should Tumor Size Be Reconsidered as a Criterion for Neoadjuvant Chemotherapy?
Identifieur interne : 001C64 ( Main/Exploration ); précédent : 001C63; suivant : 001C65In the Era of Genomics, Should Tumor Size Be Reconsidered as a Criterion for Neoadjuvant Chemotherapy?
Auteurs : Xavier Pivot ; Laura Mansi ; Loic Chaigneau ; Philippe Montcuquet ; Antoine Thiery-Vuillemin ; Fernando Bazan ; Erion Dobi ; Jean L. Sautiere ; Frederic Rigenbach ; Marie P. Algros ; Steve Butler ; Farid Jamshidian ; Phillip Febbo ; Christer Svedman ; Sophie Paget-Bailly ; Franck Bonnetain ; Christian VillanuevaSource :
- The Oncologist [ 1083-7159 ] ; 2015.
Abstract
The aim of this study was to assess the distribution of Oncotype DX recurrence score (RS) in patients selected for neoadjuvant chemotherapy primarily according to tumor size. Neoadjuvant chemotherapy provides limited benefit with no pathological complete response (pCR) observed in patients with low RS results. Inclusion of patients with such tumors in neoadjuvant trials using pCR as an efficacy measure will dilute the ability to look at treatment effects.
Url:
DOI: 10.1634/theoncologist.2014-0198
PubMed: 25795632
PubMed Central: 4391758
Affiliations:
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Algros</name><name sortKey="Bazan, Fernando" sort="Bazan, Fernando" uniqKey="Bazan F" first="Fernando" last="Bazan">Fernando Bazan</name><name sortKey="Bonnetain, Franck" sort="Bonnetain, Franck" uniqKey="Bonnetain F" first="Franck" last="Bonnetain">Franck Bonnetain</name><name sortKey="Butler, Steve" sort="Butler, Steve" uniqKey="Butler S" first="Steve" last="Butler">Steve Butler</name><name sortKey="Chaigneau, Loic" sort="Chaigneau, Loic" uniqKey="Chaigneau L" first="Loic" last="Chaigneau">Loic Chaigneau</name><name sortKey="Dobi, Erion" sort="Dobi, Erion" uniqKey="Dobi E" first="Erion" last="Dobi">Erion Dobi</name><name sortKey="Febbo, Phillip" sort="Febbo, Phillip" uniqKey="Febbo P" first="Phillip" last="Febbo">Phillip Febbo</name><name sortKey="Jamshidian, Farid" sort="Jamshidian, Farid" uniqKey="Jamshidian F" first="Farid" last="Jamshidian">Farid Jamshidian</name><name sortKey="Mansi, Laura" sort="Mansi, Laura" uniqKey="Mansi L" first="Laura" last="Mansi">Laura Mansi</name><name sortKey="Montcuquet, Philippe" sort="Montcuquet, Philippe" uniqKey="Montcuquet P" first="Philippe" last="Montcuquet">Philippe Montcuquet</name><name sortKey="Paget Bailly, Sophie" sort="Paget Bailly, Sophie" uniqKey="Paget Bailly S" first="Sophie" last="Paget-Bailly">Sophie Paget-Bailly</name><name sortKey="Pivot, Xavier" sort="Pivot, Xavier" uniqKey="Pivot X" first="Xavier" last="Pivot">Xavier Pivot</name><name sortKey="Rigenbach, Frederic" sort="Rigenbach, Frederic" uniqKey="Rigenbach F" first="Frederic" last="Rigenbach">Frederic Rigenbach</name><name sortKey="Sautiere, Jean L" sort="Sautiere, Jean L" uniqKey="Sautiere J" first="Jean L." last="Sautiere">Jean L. Sautiere</name><name sortKey="Svedman, Christer" sort="Svedman, Christer" uniqKey="Svedman C" first="Christer" last="Svedman">Christer Svedman</name><name sortKey="Thiery Vuillemin, Antoine" sort="Thiery Vuillemin, Antoine" uniqKey="Thiery Vuillemin A" first="Antoine" last="Thiery-Vuillemin">Antoine Thiery-Vuillemin</name><name sortKey="Villanueva, Christian" sort="Villanueva, Christian" uniqKey="Villanueva C" first="Christian" last="Villanueva">Christian Villanueva</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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