LymphedemaV1, Main, Exploration, bibRecordById, PMC:424428

Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.

Identifieur interne : 00E610 ( Main/Exploration ); précédent : 00E609; suivant : 00E611

Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.

Auteurs : T B Nutman ; V. Kumaraswami ; E A Ottesen

Source :

Journal of Clinical Investigation [ 0021-9738 ] ; 1987.

RBID : PMC:424428

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Antigènes d'helminthe (immunologie), Brugia (immunologie), Cinétique, Femelle, Filarioses (immunologie), Humains, Lymphokines (biosynthèse), Mâle, Production d'anticorps, Wuchereria (immunologie), Wuchereria bancrofti (immunologie), Éléphantiasis (immunologie).
MESH :
- biosynthèse : Lymphokines.
- immunologie : Antigènes d'helminthe, Brugia, Filarioses, Wuchereria, Wuchereria bancrofti, Éléphantiasis.
- Adulte, Adulte d'âge moyen, Cinétique, Femelle, Humains, Mâle, Production d'anticorps.

English descriptors

KwdEn :
- Adult, Antibody Formation, Antigens, Helminth (immunology), Brugia (immunology), Elephantiasis (immunology), Female, Filariasis (immunology), Humans, Kinetics, Lymphokines (biosynthesis), Male, Middle Aged, Wuchereria (immunology), Wuchereria bancrofti (immunology).
MESH :
- chemical , biosynthesis : Lymphokines.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filariasis, Wuchereria, Wuchereria bancrofti.
- Adult, Antibody Formation, Female, Humans, Kinetics, Male, Middle Aged.

Abstract

The antigen-specific immune unresponsiveness seen in bancroftian filariasis was studied by examining lymphokine production in peripheral blood mononuclear cells (PBMC) or PBMC subpopulations from 10 patients with asymptomatic microfilaremia, 13 patients with elephantiasis and 6 normal North Americans. In each group of patients, the kinetics of the lymphokine response and the response to mitogens and nonparasite antigens did not differ significantly. In marked contrast, when antigen-induced lymphokine production was examined, most patients with microfilaremia were unable to produce either interleukin 2 (IL-2) or gamma-interferon (i.e., were nonresponders), and the few who could (hyporesponders, generally with quite low microfilaremia levels) did so at levels significantly less than those of patients with elephantiasis, all of whom showed strong responses to parasite antigen. Removal of neither adherent cells or T8+ cells affected the parasite-specific anergy seen in those with microfilaremia, suggesting a state of T cell tolerance to the parasite in patients with this most common clinical manifestation of bancroftian filariasis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC424428

PubMed: 3553242
PubMed Central: 424428

Affiliations:

Le document en format XML

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<term>Elephantiasis (immunology)</term>
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<term>Filariasis (immunology)</term>
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<term>Filarioses (immunologie)</term>
<term>Humains</term>
<term>Lymphokines (biosynthèse)</term>
<term>Mâle</term>
<term>Production d'anticorps</term>
<term>Wuchereria (immunologie)</term>
<term>Wuchereria bancrofti (immunologie)</term>
<term>Éléphantiasis (immunologie)</term>
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<front><div type="abstract" xml:lang="en"><p>The antigen-specific immune unresponsiveness seen in bancroftian filariasis was studied by examining lymphokine production in peripheral blood mononuclear cells (PBMC) or PBMC subpopulations from 10 patients with asymptomatic microfilaremia, 13 patients with elephantiasis and 6 normal North Americans. In each group of patients, the kinetics of the lymphokine response and the response to mitogens and nonparasite antigens did not differ significantly. In marked contrast, when antigen-induced lymphokine production was examined, most patients with microfilaremia were unable to produce either interleukin 2 (IL-2) or gamma-interferon (i.e., were nonresponders), and the few who could (hyporesponders, generally with quite low microfilaremia levels) did so at levels significantly less than those of patients with elephantiasis, all of whom showed strong responses to parasite antigen. Removal of neither adherent cells or T8+ cells affected the parasite-specific anergy seen in those with microfilaremia, suggesting a state of T cell tolerance to the parasite in patients with this most common clinical manifestation of bancroftian filariasis.</p>
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Serveur d'exploration sur le lymphœdème

Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.

Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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