Quality of Life Among a Population-Based Cohort of Older Patients with Breast Cancer
Identifieur interne : 002623 ( Main/Exploration ); précédent : 002622; suivant : 002624Quality of Life Among a Population-Based Cohort of Older Patients with Breast Cancer
Auteurs : Joan M. Neuner [États-Unis] ; Nathan Zokoe [États-Unis] ; Emily L. Mcginley [États-Unis] ; Liliana E. Pezzin [États-Unis] ; Tina W. F. Yen [États-Unis] ; Marilyn M. Schapira [États-Unis] ; Ann B. Nattinger [États-Unis]Source :
- Breast (Edinburgh, Scotland) [ 0960-9776 ] ; 2014.
Descripteurs français
- KwdFr :
- Association thérapeutique, Enquêtes de santé, Enquêtes et questionnaires, Facteurs de l'âge, Femelle, Humains, Lymphoedème (psychologie), Lymphoedème (étiologie), Modèles statistiques, Qualité de vie, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein (), Tumeurs du sein (psychologie), États-Unis d'Amérique, Études de suivi.
- MESH :
- psychologie : Lymphoedème, Tumeurs du sein.
- étiologie : Lymphoedème.
- Association thérapeutique, Enquêtes de santé, Enquêtes et questionnaires, Facteurs de l'âge, Femelle, Humains, Modèles statistiques, Qualité de vie, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein, États-Unis d'Amérique, Études de suivi.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Age Factors, Aged, Aged, 80 and over, Breast Neoplasms (complications), Breast Neoplasms (psychology), Breast Neoplasms (therapy), Combined Modality Therapy, Female, Follow-Up Studies, Health Surveys, Humans, Lymphedema (etiology), Lymphedema (psychology), Models, Statistical, Quality of Life, Surveys and Questionnaires, United States.
- MESH :
- geographic : United States.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- psychology : Breast Neoplasms, Lymphedema.
- therapy : Breast Neoplasms.
- Age Factors, Aged, Aged, 80 and over, Combined Modality Therapy, Female, Follow-Up Studies, Health Surveys, Humans, Models, Statistical, Quality of Life, Surveys and Questionnaires.
Abstract
Growing numbers of older women receive adjuvant breast cancer therapies, but little is known about the long-term effects of current therapies upon health-related quality of life outside of clinical trials.
A population-based cohort of postmenopausal women with incident breast cancer aged sixty-five and older was identified from Medicare claims from four states and followed over five years. General health-related quality of life (HRQOL) was assessed using the Medical Outcomes Study SF-12 Health Survey, and breast cancer-related HRQOL was assessed using the breast cancer subscale of the functional assessment of cancer therapy (FACT-B BCS). The association of HRQOL with sociodemographic variables, comorbidity, and breast cancer variables (stage, treatments, and treatment sequelae) was examined in longitudinal models.
Among the 3,083 older breast cancer survivors, general HRQOL as measured by SF-12 mental and physical component scores was similar to norms for non-cancer populations, and remained stable throughout follow-up. Breast cancer treatments, including surgery and radiation, adjuvant hormonal therapy, and cytotoxic chemotherapy were not associated with worsened general health scores. A similar pattern was seen for breast cancer-related HRQOL scores, except that chemotherapy was associated with slightly worse scores. Lymphedema occurred in 17% of the cohort, and was strongly associated with all measures of HRQOL. Reductions in general HRQOL with lymphedema development were larger than those with an age increase of 10 years.
There is little association of breast cancer treatment with HRQOL in older breast cancer patients followed for up to five years, but the development of lymphedema is associated with substantial reductions in HRQOL.
Url:
DOI: 10.1016/j.breast.2014.06.002
PubMed: 25034932
PubMed Central: 4184951
Affiliations:
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Le document en format XML
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<author><name sortKey="Schapira, Marilyn M" sort="Schapira, Marilyn M" uniqKey="Schapira M" first="Marilyn M." last="Schapira">Marilyn M. Schapira</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Breast Neoplasms (complications)</term>
<term>Breast Neoplasms (psychology)</term>
<term>Breast Neoplasms (therapy)</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Health Surveys</term>
<term>Humans</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (psychology)</term>
<term>Models, Statistical</term>
<term>Quality of Life</term>
<term>Surveys and Questionnaires</term>
<term>United States</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Association thérapeutique</term>
<term>Enquêtes de santé</term>
<term>Enquêtes et questionnaires</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphoedème (psychologie)</term>
<term>Lymphoedème (étiologie)</term>
<term>Modèles statistiques</term>
<term>Qualité de vie</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (psychologie)</term>
<term>États-Unis d'Amérique</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Lymphoedème</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Health Surveys</term>
<term>Humans</term>
<term>Models, Statistical</term>
<term>Quality of Life</term>
<term>Surveys and Questionnaires</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Association thérapeutique</term>
<term>Enquêtes de santé</term>
<term>Enquêtes et questionnaires</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Modèles statistiques</term>
<term>Qualité de vie</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tumeurs du sein</term>
<term>États-Unis d'Amérique</term>
<term>Études de suivi</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Growing numbers of older women receive adjuvant breast cancer therapies, but little is known about the long-term effects of current therapies upon health-related quality of life outside of clinical trials.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">A population-based cohort of postmenopausal women with incident breast cancer aged sixty-five and older was identified from Medicare claims from four states and followed over five years. General health-related quality of life (HRQOL) was assessed using the Medical Outcomes Study SF-12 Health Survey, and breast cancer-related HRQOL was assessed using the breast cancer subscale of the functional assessment of cancer therapy (FACT-B BCS). The association of HRQOL with sociodemographic variables, comorbidity, and breast cancer variables (stage, treatments, and treatment sequelae) was examined in longitudinal models.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among the 3,083 older breast cancer survivors, general HRQOL as measured by SF-12 mental and physical component scores was similar to norms for non-cancer populations, and remained stable throughout follow-up. Breast cancer treatments, including surgery and radiation, adjuvant hormonal therapy, and cytotoxic chemotherapy were not associated with worsened general health scores. A similar pattern was seen for breast cancer-related HRQOL scores, except that chemotherapy was associated with slightly worse scores. Lymphedema occurred in 17% of the cohort, and was strongly associated with all measures of HRQOL. Reductions in general HRQOL with lymphedema development were larger than those with an age increase of 10 years.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">There is little association of breast cancer treatment with HRQOL in older breast cancer patients followed for up to five years, but the development of lymphedema is associated with substantial reductions in HRQOL.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
<li>Wisconsin</li>
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<tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Neuner, Joan M" sort="Neuner, Joan M" uniqKey="Neuner J" first="Joan M." last="Neuner">Joan M. Neuner</name>
</region>
<name sortKey="Mcginley, Emily L" sort="Mcginley, Emily L" uniqKey="Mcginley E" first="Emily L." last="Mcginley">Emily L. Mcginley</name>
<name sortKey="Nattinger, Ann B" sort="Nattinger, Ann B" uniqKey="Nattinger A" first="Ann B." last="Nattinger">Ann B. Nattinger</name>
<name sortKey="Nattinger, Ann B" sort="Nattinger, Ann B" uniqKey="Nattinger A" first="Ann B." last="Nattinger">Ann B. Nattinger</name>
<name sortKey="Neuner, Joan M" sort="Neuner, Joan M" uniqKey="Neuner J" first="Joan M." last="Neuner">Joan M. Neuner</name>
<name sortKey="Pezzin, Liliana E" sort="Pezzin, Liliana E" uniqKey="Pezzin L" first="Liliana E." last="Pezzin">Liliana E. Pezzin</name>
<name sortKey="Pezzin, Liliana E" sort="Pezzin, Liliana E" uniqKey="Pezzin L" first="Liliana E." last="Pezzin">Liliana E. Pezzin</name>
<name sortKey="Schapira, Marilyn M" sort="Schapira, Marilyn M" uniqKey="Schapira M" first="Marilyn M." last="Schapira">Marilyn M. Schapira</name>
<name sortKey="Yen, Tina W F" sort="Yen, Tina W F" uniqKey="Yen T" first="Tina W. F." last="Yen">Tina W. F. Yen</name>
<name sortKey="Yen, Tina W F" sort="Yen, Tina W F" uniqKey="Yen T" first="Tina W. F." last="Yen">Tina W. F. Yen</name>
<name sortKey="Zokoe, Nathan" sort="Zokoe, Nathan" uniqKey="Zokoe N" first="Nathan" last="Zokoe">Nathan Zokoe</name>
</country>
</tree>
</affiliations>
</record>
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