Non-invasive Detection of Breast Cancer Lymph Node Metastasis using Carbonic Anhydrases IX and XII Targeted Imaging Probes
Identifieur interne : 004C90 ( Main/Exploration ); précédent : 004C89; suivant : 004C91Non-invasive Detection of Breast Cancer Lymph Node Metastasis using Carbonic Anhydrases IX and XII Targeted Imaging Probes
Auteurs : Narges K. Tafreshi [États-Unis] ; Marilyn M. Bui [États-Unis] ; Kellsey Bishop [États-Unis] ; Mark C. Lloyd [États-Unis] ; Steven A. Enkemann [États-Unis] ; Alexis S. Lopez [États-Unis] ; Dominique Abrahams [États-Unis] ; Bradford W. Carter [États-Unis] ; Josef Vagner [États-Unis] ; Stephen R. Grobmyer [États-Unis] ; Robert J. Gillies [États-Unis] ; David L. Morse [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2011.
Abstract
To develop targeted molecular imaging probes for the non-invasive detection of breast cancer lymph node metastasis.
Six cell surface or secreted markers were identified by expression profiling and from the literature as being highly expressed in breast cancer lymph node metastases. Two of these markers were cell surface carbonic anhydrase isozymes (CAIX and/or CAXII) and were validated for protein expression by immunohistochemistry (IHC) of patient tissue samples on a breast cancer tissue microarray containing 47 normal breast tissue samples, 42 ductal carcinoma in situ, 43 invasive ductal carcinomas without metastasis, 46 invasive ductal carcinomas with metastasis and 49 lymph node macrometastases of breast carcinoma. Targeted probes were developed by conjugation of CAIX and CAXII specific monoclonal antibodies (mAbs) to a near-infrared fluorescent dye.
Together, these two markers were expressed in 100% of the lymph node metastases surveyed. Selectivity of the imaging probes were confirmed by intravenous injection into nude mice bearing mammary fat pad tumors of marker expressing cells, and non-expressing cells or by pre-injection of unlabeled antibody. Imaging of LN metastases showed that peritumorally-injected probes detected nodes harboring metastatic tumor cells. As few as 1,000 cells were detected, as determined by implanting, under ultrasound guidance, a range in number of CAIX and CAXII expressing cells into the axillary LNs.
These imaging probes have potential for non-invasive staging of breast cancer in the clinic and elimination of unneeded surgery, which is costly and associated with morbidities.
Url:
DOI: 10.1158/1078-0432.CCR-11-0238
PubMed: 22016510
PubMed Central: 4130557
Affiliations:
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Le document en format XML
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<author><name sortKey="Vagner, Josef" sort="Vagner, Josef" uniqKey="Vagner J" first="Josef" last="Vagner">Josef Vagner</name>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">To develop targeted molecular imaging probes for the non-invasive detection of breast cancer lymph node metastasis.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Six cell surface or secreted markers were identified by expression profiling and from the literature as being highly expressed in breast cancer lymph node metastases. Two of these markers were cell surface carbonic anhydrase isozymes (CAIX and/or CAXII) and were validated for protein expression by immunohistochemistry (IHC) of patient tissue samples on a breast cancer tissue microarray containing 47 normal breast tissue samples, 42 ductal carcinoma in situ, 43 invasive ductal carcinomas without metastasis, 46 invasive ductal carcinomas with metastasis and 49 lymph node macrometastases of breast carcinoma. Targeted probes were developed by conjugation of CAIX and CAXII specific monoclonal antibodies (mAbs) to a near-infrared fluorescent dye.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Together, these two markers were expressed in 100% of the lymph node metastases surveyed. Selectivity of the imaging probes were confirmed by intravenous injection into nude mice bearing mammary fat pad tumors of marker expressing cells, and non-expressing cells or by pre-injection of unlabeled antibody. Imaging of LN metastases showed that peritumorally-injected probes detected nodes harboring metastatic tumor cells. As few as 1,000 cells were detected, as determined by implanting, under ultrasound guidance, a range in number of CAIX and CAXII expressing cells into the axillary LNs.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">These imaging probes have potential for non-invasive staging of breast cancer in the clinic and elimination of unneeded surgery, which is costly and associated with morbidities.</p>
</sec>
</div>
</front>
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<tree><country name="États-Unis"><region name="Floride"><name sortKey="Tafreshi, Narges K" sort="Tafreshi, Narges K" uniqKey="Tafreshi N" first="Narges K." last="Tafreshi">Narges K. Tafreshi</name>
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<name sortKey="Bui, Marilyn M" sort="Bui, Marilyn M" uniqKey="Bui M" first="Marilyn M." last="Bui">Marilyn M. Bui</name>
<name sortKey="Bui, Marilyn M" sort="Bui, Marilyn M" uniqKey="Bui M" first="Marilyn M." last="Bui">Marilyn M. Bui</name>
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<name sortKey="Carter, Bradford W" sort="Carter, Bradford W" uniqKey="Carter B" first="Bradford W." last="Carter">Bradford W. Carter</name>
<name sortKey="Enkemann, Steven A" sort="Enkemann, Steven A" uniqKey="Enkemann S" first="Steven A." last="Enkemann">Steven A. Enkemann</name>
<name sortKey="Gillies, Robert J" sort="Gillies, Robert J" uniqKey="Gillies R" first="Robert J." last="Gillies">Robert J. Gillies</name>
<name sortKey="Grobmyer, Stephen R" sort="Grobmyer, Stephen R" uniqKey="Grobmyer S" first="Stephen R." last="Grobmyer">Stephen R. Grobmyer</name>
<name sortKey="Lloyd, Mark C" sort="Lloyd, Mark C" uniqKey="Lloyd M" first="Mark C." last="Lloyd">Mark C. Lloyd</name>
<name sortKey="Lopez, Alexis S" sort="Lopez, Alexis S" uniqKey="Lopez A" first="Alexis S." last="Lopez">Alexis S. Lopez</name>
<name sortKey="Morse, David L" sort="Morse, David L" uniqKey="Morse D" first="David L." last="Morse">David L. Morse</name>
<name sortKey="Vagner, Josef" sort="Vagner, Josef" uniqKey="Vagner J" first="Josef" last="Vagner">Josef Vagner</name>
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