Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma
Identifieur interne : 003649 ( Main/Exploration ); précédent : 003648; suivant : 003650Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma
Auteurs : Chao Li [République populaire de Chine] ; Jinchuan Fan [République populaire de Chine] ; Xicheng Song [République populaire de Chine] ; Bing Zhang [République populaire de Chine] ; Yu Chen [République populaire de Chine] ; Chunhua Li [République populaire de Chine] ; Kun Mi [République populaire de Chine] ; Hong Ma [République populaire de Chine] ; Yufeng Song [République populaire de Chine] ; Xiaofeng Tao [République populaire de Chine] ; Guojun Li [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC. We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC.
Ang-2 and VEGFR-3 expression was determined immunohistochemically in tumor tissues from 112 patients with OSCC; OSCC-adjacent noncancerous oral tissue from 85 OSCC patients; and normal oral mucosa from 37 cancer-free individuals. A log-rank test and Cox proportional hazard models were used to compare survival among different groups with expression of Ang-2 and VEGFR-3.
Ang-2 and VEGFR-3 expression was upregulated in OSCC compared to nontumor tissue (all
These results suggest that increased expression in tumors of Ang-2 may individually, or in combination with VEGFR-3, predict poor prognosis of OSCC.
Url:
DOI: 10.1371/journal.pone.0075388
PubMed: 24040410
PubMed Central: 3770542
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004486
- to stream Pmc, to step Curation: 004485
- to stream Pmc, to step Checkpoint: 002340
- to stream Ncbi, to step Merge: 005D43
- to stream Ncbi, to step Curation: 005D43
- to stream Ncbi, to step Checkpoint: 005D43
- to stream Main, to step Merge: 003656
- to stream Main, to step Curation: 003649
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma</title>
<author><name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fan, Jinchuan" sort="Fan, Jinchuan" uniqKey="Fan J" first="Jinchuan" last="Fan">Jinchuan Fan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Xicheng" sort="Song, Xicheng" uniqKey="Song X" first="Xicheng" last="Song">Xicheng Song</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai</wicri:regionArea>
<wicri:noRegion>Yantai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Chunhua" sort="Li, Chunhua" uniqKey="Li C" first="Chunhua" last="Li">Chunhua Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mi, Kun" sort="Mi, Kun" uniqKey="Mi K" first="Kun" last="Mi">Kun Mi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ma, Hong" sort="Ma, Hong" uniqKey="Ma H" first="Hong" last="Ma">Hong Ma</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea>
<wicri:noRegion>Guiyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea>
<wicri:noRegion>Guiyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tao, Xiaofeng" sort="Tao, Xiaofeng" uniqKey="Tao X" first="Xiaofeng" last="Tao">Xiaofeng Tao</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Guojun" sort="Li, Guojun" uniqKey="Li G" first="Guojun" last="Li">Guojun Li</name>
<affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24040410</idno>
<idno type="pmc">3770542</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770542</idno>
<idno type="RBID">PMC:3770542</idno>
<idno type="doi">10.1371/journal.pone.0075388</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">004486</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004486</idno>
<idno type="wicri:Area/Pmc/Curation">004485</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004485</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002340</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002340</idno>
<idno type="wicri:Area/Ncbi/Merge">005D43</idno>
<idno type="wicri:Area/Ncbi/Curation">005D43</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005D43</idno>
<idno type="wicri:Area/Main/Merge">003656</idno>
<idno type="wicri:Area/Main/Curation">003649</idno>
<idno type="wicri:Area/Main/Exploration">003649</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma</title>
<author><name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fan, Jinchuan" sort="Fan, Jinchuan" uniqKey="Fan J" first="Jinchuan" last="Fan">Jinchuan Fan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Xicheng" sort="Song, Xicheng" uniqKey="Song X" first="Xicheng" last="Song">Xicheng Song</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai</wicri:regionArea>
<wicri:noRegion>Yantai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan</wicri:regionArea>
<wicri:noRegion>Sichuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Chunhua" sort="Li, Chunhua" uniqKey="Li C" first="Chunhua" last="Li">Chunhua Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mi, Kun" sort="Mi, Kun" uniqKey="Mi K" first="Kun" last="Mi">Kun Mi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ma, Hong" sort="Ma, Hong" uniqKey="Ma H" first="Hong" last="Ma">Hong Ma</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea>
<wicri:noRegion>Guiyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea>
<wicri:noRegion>Guiyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tao, Xiaofeng" sort="Tao, Xiaofeng" uniqKey="Tao X" first="Xiaofeng" last="Tao">Xiaofeng Tao</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Guojun" sort="Li, Guojun" uniqKey="Li G" first="Guojun" last="Li">Guojun Li</name>
<affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC. We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC.</p>
</sec>
<sec><title>Methods</title>
<p>Ang-2 and VEGFR-3 expression was determined immunohistochemically in tumor tissues from 112 patients with OSCC; OSCC-adjacent noncancerous oral tissue from 85 OSCC patients; and normal oral mucosa from 37 cancer-free individuals. A log-rank test and Cox proportional hazard models were used to compare survival among different groups with expression of Ang-2 and VEGFR-3.</p>
</sec>
<sec><title>Results</title>
<p>Ang-2 and VEGFR-3 expression was upregulated in OSCC compared to nontumor tissue (all <italic>P</italic>
<0.05). High Ang-2 expression positively correlated with microvessel density (MVD) (<italic>P</italic>
<0.01), and high VEGFR-3 expression positively correlated with lymph node metastasis (<italic>P</italic>
<0.01) and lymphatic vessel density (LVD) (<italic>P</italic>
<0.01). The patients with high expression of Ang-2 alone or in combination with VEGFR-3 had a significantly worse survival than in patients with low expression of Ang-2 or any other co-expression status (all <italic>P</italic>
<0.05), respectively. Furthermore, multivariable analysis showed that patients with high expression of Ang-2 alone or in combination with VEGFR-3 had a significantly increased risk of death compared with those with low expression of Ang-2 or any other co-expression status (HR, 2.7, 95% CI, 1.1–6.2 and 5.0, 1.3–15.4, respectively).</p>
</sec>
<sec><title>Conclusions</title>
<p>These results suggest that increased expression in tumors of Ang-2 may individually, or in combination with VEGFR-3, predict poor prognosis of OSCC.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Massano, J" uniqKey="Massano J">J Massano</name>
</author>
<author><name sortKey="Regateiro, Fs" uniqKey="Regateiro F">FS Regateiro</name>
</author>
<author><name sortKey="Januario, G" uniqKey="Januario G">G Januário</name>
</author>
<author><name sortKey="Ferreira, A" uniqKey="Ferreira A">A Ferreira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gale, Nw" uniqKey="Gale N">NW Gale</name>
</author>
<author><name sortKey="Thurston, G" uniqKey="Thurston G">G Thurston</name>
</author>
<author><name sortKey="Hackett, Sf" uniqKey="Hackett S">SF Hackett</name>
</author>
<author><name sortKey="Renard, R" uniqKey="Renard R">R Renard</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="C, Li" uniqKey="C L">Li C</name>
</author>
<author><name sortKey="Hc, Feng" uniqKey="Hc F">Feng HC</name>
</author>
<author><name sortKey="Yf, Song" uniqKey="Yf S">Song YF</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saharinen, P" uniqKey="Saharinen P">P Saharinen</name>
</author>
<author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name>
</author>
<author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name>
</author>
<author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edge, Sb" uniqKey="Edge S">SB Edge</name>
</author>
<author><name sortKey="Compton, Cc" uniqKey="Compton C">CC Compton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bryne, M" uniqKey="Bryne M">M Bryne</name>
</author>
<author><name sortKey="Koppang, Hs" uniqKey="Koppang H">HS Koppang</name>
</author>
<author><name sortKey="Lilleng, R" uniqKey="Lilleng R">R Lilleng</name>
</author>
<author><name sortKey="Kjaerheim, A" uniqKey="Kjaerheim A">A Kjaerheim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ochiumi, T" uniqKey="Ochiumi T">T Ochiumi</name>
</author>
<author><name sortKey="Tanaka, S" uniqKey="Tanaka S">S Tanaka</name>
</author>
<author><name sortKey="Oka, S" uniqKey="Oka S">S Oka</name>
</author>
<author><name sortKey="Hiyama, T" uniqKey="Hiyama T">T Hiyama</name>
</author>
<author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weidner, N" uniqKey="Weidner N">N Weidner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nisato, Re" uniqKey="Nisato R">RE Nisato</name>
</author>
<author><name sortKey="Tille, Jc" uniqKey="Tille J">JC Tille</name>
</author>
<author><name sortKey="Pepper, Ms" uniqKey="Pepper M">MS Pepper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dumoff, Kl" uniqKey="Dumoff K">KL Dumoff</name>
</author>
<author><name sortKey="Chu, C" uniqKey="Chu C">C Chu</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
<author><name sortKey="Pasha, T" uniqKey="Pasha T">T Pasha</name>
</author>
<author><name sortKey="Zhang, Pj" uniqKey="Zhang P">PJ Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fogt, F" uniqKey="Fogt F">F Fogt</name>
</author>
<author><name sortKey="Zimmerman, Rl" uniqKey="Zimmerman R">RL Zimmerman</name>
</author>
<author><name sortKey="Ross, Hm" uniqKey="Ross H">HM Ross</name>
</author>
<author><name sortKey="Daly, T" uniqKey="Daly T">T Daly</name>
</author>
<author><name sortKey="Gausas, Re" uniqKey="Gausas R">RE Gausas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Urabe, A" uniqKey="Urabe A">A Urabe</name>
</author>
<author><name sortKey="Matsumoto, T" uniqKey="Matsumoto T">T Matsumoto</name>
</author>
<author><name sortKey="Kimura, M" uniqKey="Kimura M">M Kimura</name>
</author>
<author><name sortKey="Sonoue, H" uniqKey="Sonoue H">H Sonoue</name>
</author>
<author><name sortKey="Kinoshita, K" uniqKey="Kinoshita K">K Kinoshita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Urabe, A" uniqKey="Urabe A">A Urabe</name>
</author>
<author><name sortKey="Matsumoto, T" uniqKey="Matsumoto T">T Matsumoto</name>
</author>
<author><name sortKey="Kimura, M" uniqKey="Kimura M">M Kimura</name>
</author>
<author><name sortKey="Sonoue, H" uniqKey="Sonoue H">H Sonoue</name>
</author>
<author><name sortKey="Kinoshita, K" uniqKey="Kinoshita K">K Kinoshita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name>
</author>
<author><name sortKey="Rajantie, I" uniqKey="Rajantie I">I Rajantie</name>
</author>
<author><name sortKey="Pajusola, K" uniqKey="Pajusola K">K Pajusola</name>
</author>
<author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name>
</author>
<author><name sortKey="Holopainen, T" uniqKey="Holopainen T">T Holopainen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Botting, Sk" uniqKey="Botting S">SK Botting</name>
</author>
<author><name sortKey="Fouad, H" uniqKey="Fouad H">H Fouad</name>
</author>
<author><name sortKey="Elwell, K" uniqKey="Elwell K">K Elwell</name>
</author>
<author><name sortKey="Rampy, Ba" uniqKey="Rampy B">BA Rampy</name>
</author>
<author><name sortKey="Salama, Sa" uniqKey="Salama S">SA Salama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yashiro, M" uniqKey="Yashiro M">M Yashiro</name>
</author>
<author><name sortKey="Shinto, O" uniqKey="Shinto O">O Shinto</name>
</author>
<author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name>
</author>
<author><name sortKey="Tendo, M" uniqKey="Tendo M">M Tendo</name>
</author>
<author><name sortKey="Matsuoka, T" uniqKey="Matsuoka T">T Matsuoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yancopoulos, Gd" uniqKey="Yancopoulos G">GD Yancopoulos</name>
</author>
<author><name sortKey="Davis, S" uniqKey="Davis S">S Davis</name>
</author>
<author><name sortKey="Gale, Nw" uniqKey="Gale N">NW Gale</name>
</author>
<author><name sortKey="Rudge, Js" uniqKey="Rudge J">JS Rudge</name>
</author>
<author><name sortKey="Wiegand, Sj" uniqKey="Wiegand S">SJ Wiegand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="M Kinen, T" uniqKey="M Kinen T">T Mäkinen</name>
</author>
<author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name>
</author>
<author><name sortKey="Veikkola, T" uniqKey="Veikkola T">T Veikkola</name>
</author>
<author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name>
</author>
<author><name sortKey="Kettunen, Mi" uniqKey="Kettunen M">MI Kettunen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wigle, Jt" uniqKey="Wigle J">JT Wigle</name>
</author>
<author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holopainen, T" uniqKey="Holopainen T">T Holopainen</name>
</author>
<author><name sortKey="Saharinen, P" uniqKey="Saharinen P">P Saharinen</name>
</author>
<author><name sortKey="D Amico, G" uniqKey="D Amico G">G D'Amico</name>
</author>
<author><name sortKey="Lampinen, A" uniqKey="Lampinen A">A Lampinen</name>
</author>
<author><name sortKey="Eklund, L" uniqKey="Eklund L">L Eklund</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Texas</li>
</region>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name>
</noRegion>
<name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name>
<name sortKey="Fan, Jinchuan" sort="Fan, Jinchuan" uniqKey="Fan J" first="Jinchuan" last="Fan">Jinchuan Fan</name>
<name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name>
<name sortKey="Li, Chunhua" sort="Li, Chunhua" uniqKey="Li C" first="Chunhua" last="Li">Chunhua Li</name>
<name sortKey="Ma, Hong" sort="Ma, Hong" uniqKey="Ma H" first="Hong" last="Ma">Hong Ma</name>
<name sortKey="Mi, Kun" sort="Mi, Kun" uniqKey="Mi K" first="Kun" last="Mi">Kun Mi</name>
<name sortKey="Song, Xicheng" sort="Song, Xicheng" uniqKey="Song X" first="Xicheng" last="Song">Xicheng Song</name>
<name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name>
<name sortKey="Tao, Xiaofeng" sort="Tao, Xiaofeng" uniqKey="Tao X" first="Xiaofeng" last="Tao">Xiaofeng Tao</name>
<name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name>
</country>
<country name="États-Unis"><region name="Texas"><name sortKey="Li, Guojun" sort="Li, Guojun" uniqKey="Li G" first="Guojun" last="Li">Guojun Li</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003649 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003649 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3770542 |texte= Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24040410" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |