Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates†
Identifieur interne : 004055 ( Main/Exploration ); précédent : 004054; suivant : 004056Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates†
Auteurs : Kalicharan Cattopadhyay ; Antonio Recio [États-Unis] ; Jon A. Tunge [États-Unis]Source :
- Organic & biomolecular chemistry [ 1477-0520 ] ; 2012.
Abstract
We report the palladium-catalyzed, pyrrolidine-mediated α-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd-π-benzyl complex generated from (coumarinyl)methyl acetates.
Url:
DOI: 10.1039/c2ob25962a
PubMed: 22832549
PubMed Central: 3443958
Affiliations:
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Tunge</name><affiliation wicri:level="1"><nlm:aff id="A2">2010 Malott Hall, 1251 Wescoe Hall Dr., Lawrence, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2010 Malott Hall, 1251 Wescoe Hall Dr., Lawrence</wicri:regionArea><wicri:noRegion>Lawrence</wicri:noRegion></affiliation></author></analytic><series><title level="j">Organic & biomolecular chemistry</title><idno type="ISSN">1477-0520</idno><idno type="eISSN">1477-0539</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We report the palladium-catalyzed, pyrrolidine-mediated α-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd-π-benzyl complex generated from (coumarinyl)methyl acetates.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Cattopadhyay, Kalicharan" sort="Cattopadhyay, Kalicharan" uniqKey="Cattopadhyay K" first="Kalicharan" last="Cattopadhyay">Kalicharan Cattopadhyay</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Recio, Antonio" sort="Recio, Antonio" uniqKey="Recio A" first="Antonio" last="Recio">Antonio Recio</name></noRegion><name sortKey="Tunge, Jon A" sort="Tunge, Jon A" uniqKey="Tunge J" first="Jon A." last="Tunge">Jon A. Tunge</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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