LymphedemaV1, Main, Exploration, bibRecordById, PMC:3069509

The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases

Identifieur interne : 004A47 ( Main/Exploration ); précédent : 004A46; suivant : 004A48

The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases

Auteurs : S. Michelle Shiller ; Robert Weir ; John Pippen ; Metin Punar ; Daniel Savino

Source :

Proceedings (Baylor University. Medical Center) [ 0899-8280 ] ; 2011.

RBID : PMC:3069509

Abstract

Sentinel lymph node (SLN) biopsy has become the standard of care for breast carcinoma management, as it precludes the negative morbid effects—including decreased shoulder range of motion, lymphedema, and paresthesias—of unnecessary axillary lymph node dissection. However, the method of pathologic evaluation of the lymph node has been scrutinized to obtain the greatest sensitivity, specificity, and negative predictive value, ultimately for the benefit of the patient. This retrospective study analyzed 488 biopsies completed by two surgeons and read by multiple pathologists affiliated with Pathologists Biomedical Laboratories. When metastatic disease was not grossly obvious, analysis of the SLN began with touch imprint cytology and, if necessary, a frozen section analysis. On the subsequent day, three levels of the SLN were analyzed with hematoxylin and eosin stain and immunohistochemistry with cytokeratin AE1-3 and the appropriate control. Touch imprint cytology and/or frozen section analysis (where applicable) correctly identified 78 of 89 macrometastases, with a sensitivity of 88%, specificity of 100%, and negative predictive value of 97%. Sensitivity was 72% for micrometastases and 60% for isolated tumor cells, each with 100% specificity. In conclusion, the sensitivity and specificity of SLN biopsy at our institution compares with the higher end of percentages reported in the literature.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069509

PubMed: 21566748
PubMed Central: 3069509

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases</title>
<author><name sortKey="Shiller, S Michelle" sort="Shiller, S Michelle" uniqKey="Shiller S" first="S. Michelle" last="Shiller">S. Michelle Shiller</name>
</author>
<author><name sortKey="Weir, Robert" sort="Weir, Robert" uniqKey="Weir R" first="Robert" last="Weir">Robert Weir</name>
</author>
<author><name sortKey="Pippen, John" sort="Pippen, John" uniqKey="Pippen J" first="John" last="Pippen">John Pippen</name>
</author>
<author><name sortKey="Punar, Metin" sort="Punar, Metin" uniqKey="Punar M" first="Metin" last="Punar">Metin Punar</name>
</author>
<author><name sortKey="Savino, Daniel" sort="Savino, Daniel" uniqKey="Savino D" first="Daniel" last="Savino">Daniel Savino</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21566748</idno>
<idno type="pmc">3069509</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069509</idno>
<idno type="RBID">PMC:3069509</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">003153</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003153</idno>
<idno type="wicri:Area/Pmc/Curation">003152</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003152</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002C72</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002C72</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002631</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002631</idno>
<idno type="wicri:Area/PubMed/Curation">002631</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002631</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002631</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002631</idno>
<idno type="wicri:Area/Ncbi/Merge">004346</idno>
<idno type="wicri:Area/Ncbi/Curation">004346</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004346</idno>
<idno type="wicri:doubleKey">0899-8280:2011:Shiller S:the:sensitivity:and</idno>
<idno type="wicri:Area/Main/Merge">004A79</idno>
<idno type="wicri:Area/Main/Curation">004A47</idno>
<idno type="wicri:Area/Main/Exploration">004A47</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases</title>
<author><name sortKey="Shiller, S Michelle" sort="Shiller, S Michelle" uniqKey="Shiller S" first="S. Michelle" last="Shiller">S. Michelle Shiller</name>
</author>
<author><name sortKey="Weir, Robert" sort="Weir, Robert" uniqKey="Weir R" first="Robert" last="Weir">Robert Weir</name>
</author>
<author><name sortKey="Pippen, John" sort="Pippen, John" uniqKey="Pippen J" first="John" last="Pippen">John Pippen</name>
</author>
<author><name sortKey="Punar, Metin" sort="Punar, Metin" uniqKey="Punar M" first="Metin" last="Punar">Metin Punar</name>
</author>
<author><name sortKey="Savino, Daniel" sort="Savino, Daniel" uniqKey="Savino D" first="Daniel" last="Savino">Daniel Savino</name>
</author>
</analytic>
<series><title level="j">Proceedings (Baylor University. Medical Center)</title>
<idno type="ISSN">0899-8280</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Sentinel lymph node (SLN) biopsy has become the standard of care for breast carcinoma management, as it precludes the negative morbid effects—including decreased shoulder range of motion, lymphedema, and paresthesias—of unnecessary axillary lymph node dissection. However, the method of pathologic evaluation of the lymph node has been scrutinized to obtain the greatest sensitivity, specificity, and negative predictive value, ultimately for the benefit of the patient. This retrospective study analyzed 488 biopsies completed by two surgeons and read by multiple pathologists affiliated with Pathologists Biomedical Laboratories. When metastatic disease was not grossly obvious, analysis of the SLN began with touch imprint cytology and, if necessary, a frozen section analysis. On the subsequent day, three levels of the SLN were analyzed with hematoxylin and eosin stain and immunohistochemistry with cytokeratin AE1-3 and the appropriate control. Touch imprint cytology and/or frozen section analysis (where applicable) correctly identified 78 of 89 macrometastases, with a sensitivity of 88%, specificity of 100%, and negative predictive value of 97%. Sensitivity was 72% for micrometastases and 60% for isolated tumor cells, each with 100% specificity. In conclusion, the sensitivity and specificity of SLN biopsy at our institution compares with the higher end of percentages reported in the literature.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Pippen, John" sort="Pippen, John" uniqKey="Pippen J" first="John" last="Pippen">John Pippen</name>
<name sortKey="Punar, Metin" sort="Punar, Metin" uniqKey="Punar M" first="Metin" last="Punar">Metin Punar</name>
<name sortKey="Savino, Daniel" sort="Savino, Daniel" uniqKey="Savino D" first="Daniel" last="Savino">Daniel Savino</name>
<name sortKey="Shiller, S Michelle" sort="Shiller, S Michelle" uniqKey="Shiller S" first="S. Michelle" last="Shiller">S. Michelle Shiller</name>
<name sortKey="Weir, Robert" sort="Weir, Robert" uniqKey="Weir R" first="Robert" last="Weir">Robert Weir</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004A47 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004A47 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3069509
   |texte=   The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:21566748" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases

The sensitivity and specificity of sentinel lymph node biopsy for breast cancer at Baylor University Medical Center at Dallas: a retrospective review of 488 cases

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.