Lymphatic filariasis: detection of circulating and urinary antigen and differences in antibody isotypes complexed with circulating antigen between symptomatic and asymptomatic subjects.
Identifieur interne : 00E264 ( Main/Exploration ); précédent : 00E263; suivant : 00E265Lymphatic filariasis: detection of circulating and urinary antigen and differences in antibody isotypes complexed with circulating antigen between symptomatic and asymptomatic subjects.
Auteurs : C. Lutsch ; J Y Cesbron ; D. Henry ; J P Dessaint ; K. Wandji ; M. Ismail ; A. CapronSource :
- Clinical and Experimental Immunology [ 0009-9104 ] ; 1988.
Descripteurs français
- KwdFr :
- Animaux, Antigènes d'helminthe (urine), Brugia (immunologie), Complexe antigène-anticorps (analyse), Dosage radioimmunologique, Filariose lymphatique (immunologie), Filarioses (immunologie), Humains, Immunoglobuline G (immunologie), Immunoglobuline M (immunologie), Isotypes des immunoglobulines (immunologie), Microfilaria (immunologie), Wuchereria bancrofti (immunologie).
- MESH :
- analyse : Complexe antigène-anticorps.
- immunologie : Brugia, Filariose lymphatique, Filarioses, Immunoglobuline G, Immunoglobuline M, Isotypes des immunoglobulines, Microfilaria, Wuchereria bancrofti.
- urine : Antigènes d'helminthe.
- Animaux, Dosage radioimmunologique, Humains.
English descriptors
- KwdEn :
- Animals, Antigen-Antibody Complex (analysis), Antigens, Helminth (urine), Brugia (immunology), Elephantiasis, Filarial (immunology), Filariasis (immunology), Humans, Immunoglobulin G (immunology), Immunoglobulin Isotypes (immunology), Immunoglobulin M (immunology), Microfilariae (immunology), Radioimmunoassay, Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antigen-Antibody Complex.
- chemical , immunology : Immunoglobulin G, Immunoglobulin Isotypes, Immunoglobulin M.
- chemical , urine : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Microfilariae, Wuchereria bancrofti.
- Animals, Humans, Radioimmunoassay.
Abstract
A two-site immunoradiometric assay using a monoclonal antibody (MoAb) against Brugia malayi microfilariae allowed the detection of parasite molecules both in the serum and the urine of patients from Sri Lanka infected with Wuchereria bancrofti. Whereas 50% of patients had no antigen in their serum, all of them excreted detectable amounts of antigen in their urine, the levels being higher in symptomatic than in asymptomatic patients. The poor detection in serum appeared to be related to the presence of circulating immune complexes. It was shown that the isotype of the antibodies complexed with the circulating antigen was IgM in the asymptomatic group, while it was mainly IgG in the symptomatic patients (swelling and lymphoedema or elephantiasis). These results suggest the existence of regulatory immune mechanisms affecting the clinical expression of lymphatic filariasis.
Url:
PubMed: 3280185
PubMed Central: 1541426
Affiliations:
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Le document en format XML
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Lutsch</name></author><author><name sortKey="Cesbron, J Y" sort="Cesbron, J Y" uniqKey="Cesbron J" first="J Y" last="Cesbron">J Y Cesbron</name></author><author><name sortKey="Henry, D" sort="Henry, D" uniqKey="Henry D" first="D" last="Henry">D. Henry</name></author><author><name sortKey="Dessaint, J P" sort="Dessaint, J P" uniqKey="Dessaint J" first="J P" last="Dessaint">J P Dessaint</name></author><author><name sortKey="Wandji, K" sort="Wandji, K" uniqKey="Wandji K" first="K" last="Wandji">K. Wandji</name></author><author><name sortKey="Ismail, M" sort="Ismail, M" uniqKey="Ismail M" first="M" last="Ismail">M. Ismail</name></author><author><name sortKey="Capron, A" sort="Capron, A" uniqKey="Capron A" first="A" last="Capron">A. Capron</name></author></analytic><series><title level="j">Clinical and Experimental Immunology</title><idno type="ISSN">0009-9104</idno><idno type="eISSN">1365-2249</idno><imprint><date when="1988">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigen-Antibody Complex (analysis)</term><term>Antigens, Helminth (urine)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (immunology)</term><term>Humans</term><term>Immunoglobulin G (immunology)</term><term>Immunoglobulin Isotypes (immunology)</term><term>Immunoglobulin M (immunology)</term><term>Microfilariae (immunology)</term><term>Radioimmunoassay</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes d'helminthe (urine)</term><term>Brugia (immunologie)</term><term>Complexe antigène-anticorps (analyse)</term><term>Dosage radioimmunologique</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Humains</term><term>Immunoglobuline G (immunologie)</term><term>Immunoglobuline M (immunologie)</term><term>Isotypes des immunoglobulines (immunologie)</term><term>Microfilaria (immunologie)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigen-Antibody Complex</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulin G</term><term>Immunoglobulin Isotypes</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Complexe antigène-anticorps</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term><term>Isotypes des immunoglobulines</term><term>Microfilaria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Radioimmunoassay</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dosage radioimmunologique</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A two-site immunoradiometric assay using a monoclonal antibody (MoAb) against Brugia malayi microfilariae allowed the detection of parasite molecules both in the serum and the urine of patients from Sri Lanka infected with Wuchereria bancrofti. Whereas 50% of patients had no antigen in their serum, all of them excreted detectable amounts of antigen in their urine, the levels being higher in symptomatic than in asymptomatic patients. The poor detection in serum appeared to be related to the presence of circulating immune complexes. It was shown that the isotype of the antibodies complexed with the circulating antigen was IgM in the asymptomatic group, while it was mainly IgG in the symptomatic patients (swelling and lymphoedema or elephantiasis). These results suggest the existence of regulatory immune mechanisms affecting the clinical expression of lymphatic filariasis.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Fig. 5</label><graphic xlink:href="clinexpimmunol00101-0052-a" xlink:role="256"></graphic></fig></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Capron, A" sort="Capron, A" uniqKey="Capron A" first="A" last="Capron">A. Capron</name><name sortKey="Cesbron, J Y" sort="Cesbron, J Y" uniqKey="Cesbron J" first="J Y" last="Cesbron">J Y Cesbron</name><name sortKey="Dessaint, J P" sort="Dessaint, J P" uniqKey="Dessaint J" first="J P" last="Dessaint">J P Dessaint</name><name sortKey="Henry, D" sort="Henry, D" uniqKey="Henry D" first="D" last="Henry">D. Henry</name><name sortKey="Ismail, M" sort="Ismail, M" uniqKey="Ismail M" first="M" last="Ismail">M. Ismail</name><name sortKey="Lutsch, C" sort="Lutsch, C" uniqKey="Lutsch C" first="C" last="Lutsch">C. Lutsch</name><name sortKey="Wandji, K" sort="Wandji, K" uniqKey="Wandji K" first="K" last="Wandji">K. Wandji</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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