Efficacy of diethylcarbamazine in eradicating infection with lymphatic-dwelling filariae in humans.
Identifieur interne : 012D76 ( Main/Exploration ); précédent : 012D75; suivant : 012D77Efficacy of diethylcarbamazine in eradicating infection with lymphatic-dwelling filariae in humans.
Auteurs : E A OttesenSource :
- Reviews of infectious diseases [ 0162-0886 ]
Descripteurs français
- KwdFr :
- Additifs alimentaires, Animaux, Antihelminthiques (usage thérapeutique), Brugia, Chlorure de sodium, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (effets indésirables), Diéthylcarbamazine (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (traitement médicamenteux), Formes posologiques, Humains, Larve (), Lymphoedème (traitement médicamenteux), Relation dose-effet des médicaments, Wuchereria bancrofti, Évaluation de médicament.
- MESH :
- administration et posologie : Diéthylcarbamazine.
- effets indésirables : Diéthylcarbamazine.
- immunologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique, Lymphoedème.
- usage thérapeutique : Antihelminthiques, Diéthylcarbamazine.
- Additifs alimentaires, Animaux, Brugia, Chlorure de sodium, Formes posologiques, Humains, Larve, Relation dose-effet des médicaments, Wuchereria bancrofti, Évaluation de médicament.
English descriptors
- KwdEn :
- Animals, Anthelmintics (therapeutic use), Brugia, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (adverse effects), Diethylcarbamazine (therapeutic use), Dosage Forms, Dose-Response Relationship, Drug, Drug Evaluation, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Food Additives, Humans, Larva (drug effects), Lymphedema (drug therapy), Sodium Chloride, Wuchereria bancrofti.
- MESH :
- chemical , administration & dosage : Diethylcarbamazine.
- chemical , adverse effects : Diethylcarbamazine.
- chemical , therapeutic use : Anthelmintics, Diethylcarbamazine.
- drug effects : Larva.
- drug therapy : Elephantiasis, Filarial, Lymphedema.
- immunology : Elephantiasis, Filarial.
- Animals, Brugia, Dosage Forms, Dose-Response Relationship, Drug, Drug Evaluation, Food Additives, Humans, Sodium Chloride, Wuchereria bancrofti.
Abstract
Diethylcarbamazine (DEC) is an effective microfilaricidal drug against Wuchereria bancrofti, Brugia malayi, and Brugia timori--the three lymphatic-dwelling filariae infecting humans. However, effectiveness in killing the adult stage of these parasites has been more difficult to establish. The present review of available evidence from the literature suggests that: (1) in addition to being a microfilaricidal agent, DEC in conventional dosages effectively kills adult worms of these three parasites in many patients; (2) relatively high total dosages of DEC (including dosages considerably in excess of those currently recommended) generally give better long-term therapeutic results than lower dosages; (3) spaced doses of DEC (weekly or monthly) are more effective than the same total dosage given in consecutive daily doses; (4) chronic administration of low-dose DEC, as in medicated salt, can effectively control filariasis caused by W. bancrofti or B. malayi; and (5) rational determination of the DEC regimen ideal for the killing of adult filarial parasites awaits the development of assays capable of sensitively detecting the presence of living adult parasites.
PubMed: 3895352
Affiliations:
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Le document en format XML
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Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihelminthiques</term><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Dosage Forms</term><term>Dose-Response Relationship, Drug</term><term>Drug Evaluation</term><term>Food Additives</term><term>Humans</term><term>Sodium Chloride</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Additifs alimentaires</term><term>Animaux</term><term>Brugia</term><term>Chlorure de sodium</term><term>Formes posologiques</term><term>Humains</term><term>Larve</term><term>Relation dose-effet des médicaments</term><term>Wuchereria bancrofti</term><term>Évaluation de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diethylcarbamazine (DEC) is an effective microfilaricidal drug against Wuchereria bancrofti, Brugia malayi, and Brugia timori--the three lymphatic-dwelling filariae infecting humans. However, effectiveness in killing the adult stage of these parasites has been more difficult to establish. The present review of available evidence from the literature suggests that: (1) in addition to being a microfilaricidal agent, DEC in conventional dosages effectively kills adult worms of these three parasites in many patients; (2) relatively high total dosages of DEC (including dosages considerably in excess of those currently recommended) generally give better long-term therapeutic results than lower dosages; (3) spaced doses of DEC (weekly or monthly) are more effective than the same total dosage given in consecutive daily doses; (4) chronic administration of low-dose DEC, as in medicated salt, can effectively control filariasis caused by W. bancrofti or B. malayi; and (5) rational determination of the DEC regimen ideal for the killing of adult filarial parasites awaits the development of assays capable of sensitively detecting the presence of living adult parasites.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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