Quantitative morphological correlations of alterations in capillary permeability, following histamine and moderate burning, in the mouse diaphragm; and the effects of benzopyrones
Identifieur interne : 010317 ( Main/Exploration ); précédent : 010316; suivant : 010318Quantitative morphological correlations of alterations in capillary permeability, following histamine and moderate burning, in the mouse diaphragm; and the effects of benzopyrones
Auteurs : J. R. Casley-Smith [Australie] ; J. Window [Australie]Source :
- Microvascular Research [ 0026-2862 ] ; 1976.
Abstract
The effects of moderate burning and histamine on capillaries were studied in the diaphragms of mice by electron microscopical, quantitative stereology. Many junctions were opened, but these closed again after ∼30 min. Ten junctions which were open over parts of their depths were studied by serial sectioning. It was found that these represented junctions which were actually completely open, from the lumenal to the ablumenal surfaces, but in planes other than those of the sections. The calculated permeabilities of the capillaries while they had many open junctions were much greater than those found by experiment. This indicates that the connective tissue, not the endothelium, is the factor limiting small molecular passage; the injured vessels are, temporarily, tunnel-capillaries. The small vesicles were very little altered, although the reduction in the cellular widths may have increased transport via this system by ∼50%. In contrast to recent predictions from physiological experiments, they did not increase their diameters, rather the reverse. However, great numbers of large vacuoles appeared and were just as frequent 90 min after the injuries. If, as appears likely, these transport material across the cells, they would correspond with the physiological deductions. The effects of a mixture of two benzopyrones were studied. These increased the numbers of open junctions, but had negligible effects on the vesicles and vacuoles. While it is known that these drugs greatly reduce high-protein edemas, including those of burns, this indicates that they do not do this by reducing capillary permeability.
Url:
DOI: 10.1016/0026-2862(76)90059-5
Affiliations:
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Window</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9CDFA2FEE80C31B7AE9FB281DC4C7B021377732B</idno><date when="1976" year="1976">1976</date><idno type="doi">10.1016/0026-2862(76)90059-5</idno><idno type="url">https://api.istex.fr/document/9CDFA2FEE80C31B7AE9FB281DC4C7B021377732B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004A00</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004A00</idno><idno type="wicri:Area/Istex/Curation">004A00</idno><idno type="wicri:Area/Istex/Checkpoint">006962</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">006962</idno><idno type="wicri:doubleKey">0026-2862:1976:Casley Smith J:quantitative:morphological:correlations</idno><idno type="wicri:Area/Main/Merge">011324</idno><idno type="wicri:Area/Main/Curation">010317</idno><idno type="wicri:Area/Main/Exploration">010317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Quantitative morphological correlations of alterations in capillary permeability, following histamine and moderate burning, in the mouse diaphragm; and the effects of benzopyrones</title><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Electron Microscope Unit, University of Adelaide</wicri:regionArea><wicri:noRegion>University of Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Window, J" sort="Window, J" uniqKey="Window J" first="J." last="Window">J. Window</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Electron Microscope Unit, University of Adelaide</wicri:regionArea><wicri:noRegion>University of Adelaide</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Microvascular Research</title><title level="j" type="abbrev">YMVRE</title><idno type="ISSN">0026-2862</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1976">1976</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="279">279</biblScope><biblScope unit="page" to="305">305</biblScope></imprint><idno type="ISSN">0026-2862</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0026-2862</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of moderate burning and histamine on capillaries were studied in the diaphragms of mice by electron microscopical, quantitative stereology. Many junctions were opened, but these closed again after ∼30 min. Ten junctions which were open over parts of their depths were studied by serial sectioning. It was found that these represented junctions which were actually completely open, from the lumenal to the ablumenal surfaces, but in planes other than those of the sections. The calculated permeabilities of the capillaries while they had many open junctions were much greater than those found by experiment. This indicates that the connective tissue, not the endothelium, is the factor limiting small molecular passage; the injured vessels are, temporarily, tunnel-capillaries. The small vesicles were very little altered, although the reduction in the cellular widths may have increased transport via this system by ∼50%. In contrast to recent predictions from physiological experiments, they did not increase their diameters, rather the reverse. However, great numbers of large vacuoles appeared and were just as frequent 90 min after the injuries. If, as appears likely, these transport material across the cells, they would correspond with the physiological deductions. The effects of a mixture of two benzopyrones were studied. These increased the numbers of open junctions, but had negligible effects on the vesicles and vacuoles. While it is known that these drugs greatly reduce high-protein edemas, including those of burns, this indicates that they do not do this by reducing capillary permeability.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></noRegion><name sortKey="Window, J" sort="Window, J" uniqKey="Window J" first="J." last="Window">J. 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