Lymphomatoid papulosis: A premalignant T cell disorder
Identifieur interne : 00EF37 ( Main/Exploration ); précédent : 00EF36; suivant : 00EF38Lymphomatoid papulosis: A premalignant T cell disorder
Auteurs : Carmen G. Espinoza [États-Unis] ; Bayzar Erkman-Balis [États-Unis] ; Neil A. Fenske [États-Unis]Source :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 1985.
Abstract
In an attempt to better define the process of lymphomatoid papulosis, two cases were studied by means of light and electron microscopy, immunohistochemistry studies, including the use of monoclonal antibodies, and cytogenetic technics. About 90% of the dermal lymphoid infiltrate, including the atypical cells, reacted with antibodies that define helper-inducer T cells. Only a few cells, about 5%, reacted with antibodies that define cytotoxic-suppressor T cells. Langerhans cells were increased mostly within the epidermis, and in the dermis they were in close proximity to lymphoid cells. Cytogenetic studies disclosed an abnormal hypertetraploid karyotype in dividing cells from the skin lesion, whereas skin fibroblast and phytohemagglutinin-stimulated cells from peripheral blood cultures had a diploid karyotype. The results support the concept that lymphomatoid papulosis is a disorder characterized by a predominance of helper-inducer T cells, including the atypical cells bearing an abnormal karyotype.
Url:
DOI: 10.1016/S0190-9622(85)70215-0
Affiliations:
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Espinoza</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Erkman Balis, Bayzar" sort="Erkman Balis, Bayzar" uniqKey="Erkman Balis B" first="Bayzar" last="Erkman-Balis">Bayzar Erkman-Balis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fenske, Neil A" sort="Fenske, Neil A" uniqKey="Fenske N" first="Neil A." last="Fenske">Neil A. Fenske</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American Academy of Dermatology</title><title level="j" type="abbrev">YMJD</title><idno type="ISSN">0190-9622</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="supplement">P1</biblScope><biblScope unit="page" from="736">736</biblScope><biblScope unit="page" to="743">743</biblScope></imprint><idno type="ISSN">0190-9622</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0190-9622</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In an attempt to better define the process of lymphomatoid papulosis, two cases were studied by means of light and electron microscopy, immunohistochemistry studies, including the use of monoclonal antibodies, and cytogenetic technics. About 90% of the dermal lymphoid infiltrate, including the atypical cells, reacted with antibodies that define helper-inducer T cells. Only a few cells, about 5%, reacted with antibodies that define cytotoxic-suppressor T cells. Langerhans cells were increased mostly within the epidermis, and in the dermis they were in close proximity to lymphoid cells. Cytogenetic studies disclosed an abnormal hypertetraploid karyotype in dividing cells from the skin lesion, whereas skin fibroblast and phytohemagglutinin-stimulated cells from peripheral blood cultures had a diploid karyotype. The results support the concept that lymphomatoid papulosis is a disorder characterized by a predominance of helper-inducer T cells, including the atypical cells bearing an abnormal karyotype.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Espinoza, Carmen G" sort="Espinoza, Carmen G" uniqKey="Espinoza C" first="Carmen G." last="Espinoza">Carmen G. Espinoza</name></region><name sortKey="Erkman Balis, Bayzar" sort="Erkman Balis, Bayzar" uniqKey="Erkman Balis B" first="Bayzar" last="Erkman-Balis">Bayzar Erkman-Balis</name><name sortKey="Fenske, Neil A" sort="Fenske, Neil A" uniqKey="Fenske N" first="Neil A." last="Fenske">Neil A. Fenske</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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