LymphedemaV1, Main, Exploration, bibRecord, 00EE00

Brugia pahangi in the BALB/C mouse: a model for testing filaricidal compounds.

Identifieur interne : 00EE00 ( Main/Exploration ); précédent : 00ED99; suivant : 00EE01

Brugia pahangi in the BALB/C mouse: a model for testing filaricidal compounds.

Auteurs : E. Devaney ; R E Howells ; G. Smith

Source :

Journal of helminthology [ 0022-149X ] ; 1985.

RBID : pubmed:3843374

Descripteurs français

KwdFr :
- Animaux, Antihelminthiques (usage thérapeutique), Brugia, Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Lymphoedème (traitement médicamenteux), Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée BALB C.
MESH :
- traitement médicamenteux : Filariose lymphatique, Lymphoedème.
- usage thérapeutique : Antihelminthiques, Filaricides.
- Animaux, Brugia, Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée BALB C.

English descriptors

KwdEn :
- Animals, Anthelmintics (therapeutic use), Brugia, Disease Models, Animal, Elephantiasis, Filarial (drug therapy), Filaricides (therapeutic use), Lymphedema (drug therapy), Male, Mice, Mice, Inbred BALB C.
MESH :
- chemical , therapeutic use : Anthelmintics, Filaricides.
- drug therapy : Elephantiasis, Filarial, Lymphedema.
- Animals, Brugia, Disease Models, Animal, Male, Mice, Mice, Inbred BALB C.

Abstract

The BALB/C mouse infected with Brugia pahangi has been evaluated as a model for the selection of filaricidal compounds with activity against immature worms. Mice were infected by the intraperitoneal inoculation of 50 infective larvae and candidate compounds were administered by the intraperitoneal (i.p.), subcutaneous or oral route once daily from day 4 to day 8 post infection. Animals were examined on days 29 to 32 post infection. Variation in the larval recoveries from undrugged mice within and between experimental groups limited the value of drug assessments based upon percentage worm recoveries. The infection rate of undrugged mice was 85% over-all, range 60 to 100%. Using the infection rate of drugged v. undrugged animals as the criterion of activity the test has been evaluated with a series of standard nematicidal compounds. Levamisole and the benzimidazole carbamates, mebendazole, flubendazole and fenbendazole given i.p. at 10 mg/kg daily were active in this screen whilst DEC, DEC-N-oxide, ivermectin, amoscanate, metrifonate and suramin were inactive at the dosages tested. No retardation of growth or morphological abnormalities were observed in worms from the drugged mice.

PubMed: 3843374

Affiliations:

Le document en format XML

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<author><name sortKey="Howells, R E" sort="Howells, R E" uniqKey="Howells R" first="R E" last="Howells">R E Howells</name>
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<author><name sortKey="Smith, G" sort="Smith, G" uniqKey="Smith G" first="G" last="Smith">G. Smith</name>
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<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Filaricides (therapeutic use)</term>
<term>Lymphedema (drug therapy)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<term>Antihelminthiques (usage thérapeutique)</term>
<term>Brugia</term>
<term>Filaricides (usage thérapeutique)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Lymphoedème (traitement médicamenteux)</term>
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<term>Mâle</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Lymphoedème</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihelminthiques</term>
<term>Filaricides</term>
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<term>Disease Models, Animal</term>
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<term>Mice, Inbred BALB C</term>
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<term>Brugia</term>
<term>Modèles animaux de maladie humaine</term>
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<term>Souris</term>
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<front><div type="abstract" xml:lang="en">The BALB/C mouse infected with Brugia pahangi has been evaluated as a model for the selection of filaricidal compounds with activity against immature worms. Mice were infected by the intraperitoneal inoculation of 50 infective larvae and candidate compounds were administered by the intraperitoneal (i.p.), subcutaneous or oral route once daily from day 4 to day 8 post infection. Animals were examined on days 29 to 32 post infection. Variation in the larval recoveries from undrugged mice within and between experimental groups limited the value of drug assessments based upon percentage worm recoveries. The infection rate of undrugged mice was 85% over-all, range 60 to 100%. Using the infection rate of drugged v. undrugged animals as the criterion of activity the test has been evaluated with a series of standard nematicidal compounds. Levamisole and the benzimidazole carbamates, mebendazole, flubendazole and fenbendazole given i.p. at 10 mg/kg daily were active in this screen whilst DEC, DEC-N-oxide, ivermectin, amoscanate, metrifonate and suramin were inactive at the dosages tested. No retardation of growth or morphological abnormalities were observed in worms from the drugged mice.</div>
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<name sortKey="Smith, G" sort="Smith, G" uniqKey="Smith G" first="G" last="Smith">G. Smith</name>
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Serveur d'exploration sur le lymphœdème

Brugia pahangi in the BALB/C mouse: a model for testing filaricidal compounds.

Brugia pahangi in the BALB/C mouse: a model for testing filaricidal compounds.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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