The induction of functional mononuclear and multinuclear macrophages in murine brugian filariasis: morphological and immunological properties.
Identifieur interne : 00ED35 ( Main/Exploration ); précédent : 00ED34; suivant : 00ED36The induction of functional mononuclear and multinuclear macrophages in murine brugian filariasis: morphological and immunological properties.
Auteurs : C D Mackenzie ; S L Oxenham ; D A Liron ; D. Grennan ; D A DenhamSource :
- Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [ 0177-2392 ] ; 1985.
Descripteurs français
- KwdFr :
- Activation des macrophages, Adhérence cellulaire, Animaux, Brugia (croissance et développement), Brugia (immunologie), Cavité péritonéale (anatomopathologie), Cavité péritonéale (parasitologie), Cytoplasme (ultrastructure), Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Granulocytes éosinophiles, Lymphoedème (immunologie), Macrophages (immunologie), Macrophages (ultrastructure), Membrane cellulaire (ultrastructure), Microfilaria (immunologie), Microscopie électronique, Noyau de la cellule (ultrastructure), Numération cellulaire, Phagocytose, Récepteur Fc (analyse), Récepteurs au C3b du complément, Récepteurs au complément (analyse), Souris, Souris de lignée CBA, Vacuoles (ultrastructure).
- MESH :
- analyse : Récepteur Fc, Récepteurs au complément.
- anatomopathologie : Cavité péritonéale, Filariose lymphatique.
- croissance et développement : Brugia.
- immunologie : Brugia, Filariose lymphatique, Lymphoedème, Macrophages, Microfilaria.
- parasitologie : Cavité péritonéale, Filariose lymphatique.
- ultrastructure : Activation des macrophages, Adhérence cellulaire, Animaux, Cytoplasme, Femelle, Granulocytes éosinophiles, Macrophages, Membrane cellulaire, Microscopie électronique, Noyau de la cellule, Numération cellulaire, Phagocytose, Récepteurs au C3b du complément, Souris, Souris de lignée CBA, Vacuoles.
English descriptors
- KwdEn :
- Animals, Brugia (growth & development), Brugia (immunology), Cell Adhesion, Cell Count, Cell Membrane (ultrastructure), Cell Nucleus (ultrastructure), Cytoplasm (ultrastructure), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Eosinophils, Female, Lymphedema (immunology), Macrophage Activation, Macrophages (immunology), Macrophages (ultrastructure), Mice, Mice, Inbred CBA, Microfilariae (immunology), Microscopy, Electron, Peritoneal Cavity (parasitology), Peritoneal Cavity (pathology), Phagocytosis, Receptors, Complement (analysis), Receptors, Complement 3b, Receptors, Fc (analysis), Vacuoles (ultrastructure).
- MESH :
- chemical , analysis : Receptors, Complement, Receptors, Fc.
- growth & development : Brugia.
- immunology : Brugia, Elephantiasis, Filarial, Lymphedema, Macrophages, Microfilariae.
- parasitology : Elephantiasis, Filarial, Peritoneal Cavity.
- pathology : Elephantiasis, Filarial, Peritoneal Cavity.
- ultrastructure : Cell Membrane, Cell Nucleus, Cytoplasm, Macrophages, Vacuoles.
- Animals, Cell Adhesion, Cell Count, Eosinophils, Female, Macrophage Activation, Mice, Mice, Inbred CBA, Microscopy, Electron, Phagocytosis, Receptors, Complement 3b.
Abstract
This present study describes the ontogeny and morphology of mononuclear and multinuclear macrophages in murine Brugia pahangi infections. Intraperitoneal infection with L 3 resulted in the development of adult worms and the production of microfilariae in many mice; however, all worms were usually removed by 100 days post infection (p.i.). The infection induced predominantly mononuclear and multinuclear macrophage responses in the peritoneal cavity, with maximum numbers of peritoneal cells being achieved by 8-12 weeks p.i. and at this time some 20% of the macrophages were multinucleated. Lymphocyte numbers were also increased during infection. The reactions around the filariae involved macrophages (both single and multinucleated), eosinophils, fibroblasts and the laying down of collagen. Most worms were involved in these cellular reactions by 5-6 weeks p.i., with the multinuclear macrophages generally seen lying close to the parasites. All stages of parasites developed vacuolar internal changes early in their degeneration with calcification being a later change. The destruction and removal of the sheath was not apparently a prerequisite for degeneration of the body of microfilariae. Rosetting techniques showed that 75% of peritoneal cells (macrophages) in infected animals possessed Fc receptors compared with 32% of those in uninfected mice, and for C3 receptors the respective results were 35% and 5%. The multinuclear cells possessed both types of receptors at levels similar to those of mononuclear macrophages. Likewise both cell types were found to readily phagocytose yeast and latex particles, as well as staining positively for non-specific esterases.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed: 2934789
Affiliations:
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Le document en format XML
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Grennan</name></author><author><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></author></analytic><series><title level="j">Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)</title><idno type="ISSN">0177-2392</idno><imprint><date when="1985" type="published">1985</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia (growth & development)</term><term>Brugia (immunology)</term><term>Cell Adhesion</term><term>Cell Count</term><term>Cell Membrane (ultrastructure)</term><term>Cell Nucleus (ultrastructure)</term><term>Cytoplasm (ultrastructure)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial 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lymphatique (anatomopathologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Granulocytes éosinophiles</term><term>Lymphoedème (immunologie)</term><term>Macrophages (immunologie)</term><term>Macrophages (ultrastructure)</term><term>Membrane cellulaire (ultrastructure)</term><term>Microfilaria (immunologie)</term><term>Microscopie électronique</term><term>Noyau de la cellule (ultrastructure)</term><term>Numération cellulaire</term><term>Phagocytose</term><term>Récepteur Fc (analyse)</term><term>Récepteurs au C3b du complément</term><term>Récepteurs au complément (analyse)</term><term>Souris</term><term>Souris de lignée CBA</term><term>Vacuoles (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Complement</term><term>Receptors, Fc</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Récepteur Fc</term><term>Récepteurs au 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xml:lang="en"><term>Elephantiasis, Filarial</term><term>Peritoneal Cavity</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Peritoneal Cavity</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Cell Membrane</term><term>Cell Nucleus</term><term>Cytoplasm</term><term>Macrophages</term><term>Vacuoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Adhesion</term><term>Cell Count</term><term>Eosinophils</term><term>Female</term><term>Macrophage Activation</term><term>Mice</term><term>Mice, Inbred CBA</term><term>Microscopy, Electron</term><term>Phagocytosis</term><term>Receptors, Complement 3b</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Activation des macrophages</term><term>Adhérence cellulaire</term><term>Animaux</term><term>Cytoplasme</term><term>Femelle</term><term>Granulocytes éosinophiles</term><term>Macrophages</term><term>Membrane cellulaire</term><term>Microscopie électronique</term><term>Noyau de la cellule</term><term>Numération cellulaire</term><term>Phagocytose</term><term>Récepteurs au C3b du complément</term><term>Souris</term><term>Souris de lignée CBA</term><term>Vacuoles</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This present study describes the ontogeny and morphology of mononuclear and multinuclear macrophages in murine Brugia pahangi infections. Intraperitoneal infection with L 3 resulted in the development of adult worms and the production of microfilariae in many mice; however, all worms were usually removed by 100 days post infection (p.i.). The infection induced predominantly mononuclear and multinuclear macrophage responses in the peritoneal cavity, with maximum numbers of peritoneal cells being achieved by 8-12 weeks p.i. and at this time some 20% of the macrophages were multinucleated. Lymphocyte numbers were also increased during infection. The reactions around the filariae involved macrophages (both single and multinucleated), eosinophils, fibroblasts and the laying down of collagen. Most worms were involved in these cellular reactions by 5-6 weeks p.i., with the multinuclear macrophages generally seen lying close to the parasites. All stages of parasites developed vacuolar internal changes early in their degeneration with calcification being a later change. The destruction and removal of the sheath was not apparently a prerequisite for degeneration of the body of microfilariae. Rosetting techniques showed that 75% of peritoneal cells (macrophages) in infected animals possessed Fc receptors compared with 32% of those in uninfected mice, and for C3 receptors the respective results were 35% and 5%. The multinuclear cells possessed both types of receptors at levels similar to those of mononuclear macrophages. Likewise both cell types were found to readily phagocytose yeast and latex particles, as well as staining positively for non-specific esterases.(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name><name sortKey="Grennan, D" sort="Grennan, D" uniqKey="Grennan D" first="D" last="Grennan">D. Grennan</name><name sortKey="Liron, D A" sort="Liron, D A" uniqKey="Liron D" first="D A" last="Liron">D A Liron</name><name sortKey="Mackenzie, C D" sort="Mackenzie, C D" uniqKey="Mackenzie C" first="C D" last="Mackenzie">C D Mackenzie</name><name sortKey="Oxenham, S L" sort="Oxenham, S L" uniqKey="Oxenham S" first="S L" last="Oxenham">S L Oxenham</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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