IgE responses in human filariasis. IV. Parallel antigen recognition by IgE and IgG4 subclass antibodies.
Identifieur interne : 00EA02 ( Main/Exploration ); précédent : 00EA01; suivant : 00EA03IgE responses in human filariasis. IV. Parallel antigen recognition by IgE and IgG4 subclass antibodies.
Auteurs : R. Hussain ; E A OttesenSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 1986.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (analyse), Antigènes d'helminthe (immunologie), Brugia (immunologie), Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Humains, Immunoglobuline E (analyse), Immunoglobuline E (biosynthèse), Immunoglobuline E (métabolisme), Immunoglobuline G (), Immunoglobuline G (biosynthèse), Immunoglobuline G (métabolisme), Lymphoedème (immunologie), Maladie chronique, Mâle, Poumon éosinophile (immunologie), Sites de fixation des anticorps, Sujet âgé.
- MESH :
- analyse : Antigènes d'helminthe, Immunoglobuline E.
- anatomopathologie : Filariose lymphatique.
- biosynthèse : Immunoglobuline E, Immunoglobuline G.
- immunologie : Antigènes d'helminthe, Brugia, Filariose lymphatique, Lymphoedème, Poumon éosinophile.
- métabolisme : Immunoglobuline E, Immunoglobuline G.
- parasitologie : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Immunoglobuline G, Maladie chronique, Mâle, Sites de fixation des anticorps, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antigens, Helminth (analysis), Antigens, Helminth (immunology), Binding Sites, Antibody, Brugia (immunology), Chronic Disease, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Female, Humans, Immunoglobulin E (analysis), Immunoglobulin E (biosynthesis), Immunoglobulin E (metabolism), Immunoglobulin G (biosynthesis), Immunoglobulin G (classification), Immunoglobulin G (metabolism), Lymphedema (immunology), Male, Middle Aged, Pulmonary Eosinophilia (immunology).
- MESH :
- chemical , analysis : Antigens, Helminth, Immunoglobulin E.
- chemical , biosynthesis : Immunoglobulin E, Immunoglobulin G.
- chemical , classification : Immunoglobulin G.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Lymphedema, Pulmonary Eosinophilia.
- chemical , metabolism : Immunoglobulin E, Immunoglobulin G.
- parasitology : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Animals, Binding Sites, Antibody, Chronic Disease, Female, Humans, Male, Middle Aged.
Abstract
Immediate hypersensitivity responses are highly modulated in filariasis, and with few exceptions, the majority of infected individuals do not develop allergic manifestations. One possible mechanism for this modulated responsiveness could involve the high levels of IgG "blocking antibodies" shown to be present in filariasis and other chronic helminth infections. When immunoblot analyses were done to analyze the immunoglobulin (Ig) E and IgG antibody responses of patients simultaneously, remarkable similarity in the patterns of antigen binding was observed. In this study, the four IgG subclasses were analyzed in a similar manner in relation to IgE. The results clearly demonstrate that IgG4 was primarily responsible for this "parallel" recognition that was seen previously between IgG and IgE antibodies. These results lend additional support to the possibility that IgG4 may play an important role in modulating IgE-mediated allergic responses in vivo.
PubMed: 3950405
Affiliations:
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IV. Parallel antigen recognition by IgE and IgG4 subclass antibodies.</title><author><name sortKey="Hussain, R" sort="Hussain, R" uniqKey="Hussain R" first="R" last="Hussain">R. 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One possible mechanism for this modulated responsiveness could involve the high levels of IgG "blocking antibodies" shown to be present in filariasis and other chronic helminth infections. When immunoblot analyses were done to analyze the immunoglobulin (Ig) E and IgG antibody responses of patients simultaneously, remarkable similarity in the patterns of antigen binding was observed. In this study, the four IgG subclasses were analyzed in a similar manner in relation to IgE. The results clearly demonstrate that IgG4 was primarily responsible for this "parallel" recognition that was seen previously between IgG and IgE antibodies. These results lend additional support to the possibility that IgG4 may play an important role in modulating IgE-mediated allergic responses in vivo.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hussain, R" sort="Hussain, R" uniqKey="Hussain R" first="R" last="Hussain">R. Hussain</name><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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