LymphedemaV1, Main, Exploration, bibRecord, 00E631

Immunodiagnosis of bancroftian filariasis.

Identifieur interne : 00E631 ( Main/Exploration ); précédent : 00E630; suivant : 00E632

Immunodiagnosis of bancroftian filariasis.

Auteurs : S. Dissanayake ; M M Ismail

Source :

Ciba Foundation symposium [ 0300-5208 ] ; 1987.

RBID : pubmed:2439264

Descripteurs français

KwdFr :
- Animaux, Anticorps (analyse), Antigènes d'helminthe (analyse), Antigènes de surface (analyse), Filariose lymphatique (diagnostic), Humains, Lymphoedème (diagnostic), Microfilaria (immunologie), Tests immunologiques, Wuchereria (immunologie), Wuchereria bancrofti (immunologie), Épitopes (analyse).
MESH :
- analyse : Anticorps, Antigènes d'helminthe, Antigènes de surface, Épitopes.
- diagnostic : Filariose lymphatique, Lymphoedème.
- immunologie : Microfilaria, Wuchereria, Wuchereria bancrofti.
- Animaux, Humains, Tests immunologiques.

English descriptors

KwdEn :
- Animals, Antibodies (analysis), Antigens, Helminth (analysis), Antigens, Surface (analysis), Elephantiasis, Filarial (diagnosis), Epitopes (analysis), Humans, Immunologic Tests, Lymphedema (diagnosis), Microfilariae (immunology), Wuchereria (immunology), Wuchereria bancrofti (immunology).
MESH :
- chemical , analysis : Antibodies, Antigens, Helminth, Antigens, Surface, Epitopes.
- diagnosis : Elephantiasis, Filarial, Lymphedema.
- immunology : Microfilariae, Wuchereria, Wuchereria bancrofti.
- Animals, Humans, Immunologic Tests.

Abstract

The development of immunodiagnostic tests (IDTs) for bancroftian filariasis must be aimed at defined objectives, such as the determination of exposure rates, the detection of microfilaraemia and the diagnosis of clinical filariasis. Assays for both antibody and antigen detection are necessary. Antigen determination may be more appropriate in the detection of microfilaraemia, but for clinical filariasis, antibody determination may prove more useful. The microfilarial surface antigens are very good candidates for this purpose. Determination of antibody to larval antigens may be the best way of establishing exposure rates for epidemiological purposes. An important prerequisite for IDT development is the characterization of antigens at epitope level. Sharing of antigen epitopes with host antigens could be a major limitation in IDT development. An understanding of the parasitological and immunological background of the endemic locality is also necessary. It is recommended that all IDTs are evaluated in follow-up case studies.

PubMed: 2439264

Affiliations:

Le document en format XML

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<term>Elephantiasis, Filarial (diagnosis)</term>
<term>Epitopes (analysis)</term>
<term>Humans</term>
<term>Immunologic Tests</term>
<term>Lymphedema (diagnosis)</term>
<term>Microfilariae (immunology)</term>
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<term>Anticorps (analyse)</term>
<term>Antigènes d'helminthe (analyse)</term>
<term>Antigènes de surface (analyse)</term>
<term>Filariose lymphatique (diagnostic)</term>
<term>Humains</term>
<term>Lymphoedème (diagnostic)</term>
<term>Microfilaria (immunologie)</term>
<term>Tests immunologiques</term>
<term>Wuchereria (immunologie)</term>
<term>Wuchereria bancrofti (immunologie)</term>
<term>Épitopes (analyse)</term>
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<term>Antigens, Helminth</term>
<term>Antigens, Surface</term>
<term>Epitopes</term>
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<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps</term>
<term>Antigènes d'helminthe</term>
<term>Antigènes de surface</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Microfilaria</term>
<term>Wuchereria</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Microfilariae</term>
<term>Wuchereria</term>
<term>Wuchereria bancrofti</term>
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<term>Humans</term>
<term>Immunologic Tests</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en">The development of immunodiagnostic tests (IDTs) for bancroftian filariasis must be aimed at defined objectives, such as the determination of exposure rates, the detection of microfilaraemia and the diagnosis of clinical filariasis. Assays for both antibody and antigen detection are necessary. Antigen determination may be more appropriate in the detection of microfilaraemia, but for clinical filariasis, antibody determination may prove more useful. The microfilarial surface antigens are very good candidates for this purpose. Determination of antibody to larval antigens may be the best way of establishing exposure rates for epidemiological purposes. An important prerequisite for IDT development is the characterization of antigens at epitope level. Sharing of antigen epitopes with host antigens could be a major limitation in IDT development. An understanding of the parasitological and immunological background of the endemic locality is also necessary. It is recommended that all IDTs are evaluated in follow-up case studies.</div>
</front>
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Serveur d'exploration sur le lymphœdème

Immunodiagnosis of bancroftian filariasis.

Immunodiagnosis of bancroftian filariasis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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