LymphedemaV1, Main, Exploration, bibRecord, 00DE33

Lymphocyte subpopulations in Bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction.

Identifieur interne : 00DE33 ( Main/Exploration ); précédent : 00DE32; suivant : 00DE34

Lymphocyte subpopulations in Bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction.

Auteurs : R B Lal ; V. Kumaraswami ; N. Krishnan ; T B Nutman ; E A Ottesen

Source :

Clinical and Experimental Immunology [ 0009-9104 ] ; 1989.

RBID : PMC:1541923

Descripteurs français

KwdFr :
- Activation des lymphocytes, Adulte, Adulte d'âge moyen, Animaux, Antigènes HLA-DR (analyse), Femelle, Filariose lymphatique (immunologie), Filarioses (immunologie), Humains, Lymphocytes T cytotoxiques (immunologie), Lymphocytes T régulateurs (immunologie), Mâle, Numération des leucocytes, Sujet âgé, Wuchereria bancrofti.
MESH :
- analyse : Antigènes HLA-DR.
- immunologie : Filariose lymphatique, Filarioses, Lymphocytes T cytotoxiques, Lymphocytes T régulateurs.
- Activation des lymphocytes, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Mâle, Numération des leucocytes, Sujet âgé, Wuchereria bancrofti.

English descriptors

KwdEn :
- Adult, Aged, Animals, Elephantiasis, Filarial (immunology), Female, Filariasis (immunology), HLA-DR Antigens (analysis), Humans, Leukocyte Count, Lymphocyte Activation, Male, Middle Aged, T-Lymphocytes, Cytotoxic (immunology), T-Lymphocytes, Regulatory (immunology), Wuchereria bancrofti.
MESH :
- chemical , analysis : HLA-DR Antigens.
- immunology : Elephantiasis, Filarial, Filariasis, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Regulatory.
- Adult, Aged, Animals, Female, Humans, Leukocyte Count, Lymphocyte Activation, Male, Middle Aged, Wuchereria bancrofti.

Abstract

To examine the relationship between lymphocyte phenotypes and states of activation in patients with Bancroftian filariasis, dual colour flow cytometry and concurrent in vitro cell culture were performed on normal individuals (NV; n = 15), and on patients with either asymptomatic microfilaraemia (MF; n = 12) or elephantiasis (CP; n = 11). In contrast to findings by others in a population with Brugian filariasis, the percentages of total B lymphocytes (CD19), T lymphocytes (CD3), helper/inducer T lymphocytes (CD4), and suppressor/cytotoxic T lymphocytes (CD8) in both patient groups were found to be within the range defined by clinically normal individuals. Furthermore, there were no differences among the groups in the expression of the IL-2 receptor (CD25) on T cells. There was, however, a significantly greater proportion (P less than 0.01) of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 +/- 8.6%) than in the MF (8.9 +/- 2.6%) or NV (8.3 +/- 2.9%) groups. Further, when the expression of this activation antigen was examined in parallel with in vitro mitogen responsiveness, an inverse correlation between the percentage of CD8+ HLA-DR+ lymphocytes and pokeweed mitogen-induced proliferation was seen (r = -0.54; P less than 0.001). These data provide further definition of the immunoregulatory abnormalities seen in human filarial infections and suggest that activated CD8+ T lymphocytes may be involved in the pathogenesis of the chronic obstructed lymphatic form of this disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541923

PubMed: 2527654
PubMed Central: 1541923

Affiliations:

Le document en format XML

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<term>Female</term>
<term>Filariasis (immunology)</term>
<term>HLA-DR Antigens (analysis)</term>
<term>Humans</term>
<term>Leukocyte Count</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>T-Lymphocytes, Cytotoxic (immunology)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>Wuchereria bancrofti</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
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<term>Antigènes HLA-DR (analyse)</term>
<term>Femelle</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filarioses (immunologie)</term>
<term>Humains</term>
<term>Lymphocytes T cytotoxiques (immunologie)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Mâle</term>
<term>Numération des leucocytes</term>
<term>Sujet âgé</term>
<term>Wuchereria bancrofti</term>
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<term>Filarioses</term>
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<term>Lymphocytes T régulateurs</term>
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<term>T-Lymphocytes, Regulatory</term>
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<term>Middle Aged</term>
<term>Wuchereria bancrofti</term>
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<term>Adulte d'âge moyen</term>
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<term>Femelle</term>
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<term>Numération des leucocytes</term>
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<front><div type="abstract" xml:lang="en"><p>To examine the relationship between lymphocyte phenotypes and states of activation in patients with Bancroftian filariasis, dual colour flow cytometry and concurrent in vitro cell culture were performed on normal individuals (NV; n = 15), and on patients with either asymptomatic microfilaraemia (MF; n = 12) or elephantiasis (CP; n = 11). In contrast to findings by others in a population with Brugian filariasis, the percentages of total B lymphocytes (CD19), T lymphocytes (CD3), helper/inducer T lymphocytes (CD4), and suppressor/cytotoxic T lymphocytes (CD8) in both patient groups were found to be within the range defined by clinically normal individuals. Furthermore, there were no differences among the groups in the expression of the IL-2 receptor (CD25) on T cells. There was, however, a significantly greater proportion (P less than 0.01) of 'activated' cytotoxic/suppressor lymphocytes (defined by co-expression of CD8 and HLA-DR) in patients with elephantiasis (16.4 +/- 8.6%) than in the MF (8.9 +/- 2.6%) or NV (8.3 +/- 2.9%) groups. Further, when the expression of this activation antigen was examined in parallel with in vitro mitogen responsiveness, an inverse correlation between the percentage of CD8+ HLA-DR+ lymphocytes and pokeweed mitogen-induced proliferation was seen (r = -0.54; P less than 0.001). These data provide further definition of the immunoregulatory abnormalities seen in human filarial infections and suggest that activated CD8+ T lymphocytes may be involved in the pathogenesis of the chronic obstructed lymphatic form of this disease.</p>
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Lymphocyte subpopulations in Bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction.

Lymphocyte subpopulations in Bancroftian filariasis: activated (DR+) CD8+ T cells in patients with chronic lymphatic obstruction.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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