Antibodies to microfilarial sheath in bancroftian filariasis--prevalence and characterization.
Identifieur interne : 00DA66 ( Main/Exploration ); précédent : 00DA65; suivant : 00DA67Antibodies to microfilarial sheath in bancroftian filariasis--prevalence and characterization.
Auteurs : B. Ravindran ; A K Satapathy ; M K Das ; N M Pattnaik ; V R SubramanyamSource :
- Annals of tropical medicine and parasitology [ 0003-4983 ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (analyse), Antigènes de surface (immunologie), Filariose lymphatique (immunologie), Humains, Immunoglobuline G (analyse), Immunoglobuline M (analyse), Microfilaria (immunologie), Technique d'immunofluorescence, Techniques immunoenzymatiques, Température élevée, Wuchereria bancrofti (immunologie).
- MESH :
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (analysis), Antigens, Surface (immunology), Elephantiasis, Filarial (immunology), Fluorescent Antibody Technique, Hot Temperature, Humans, Immunoenzyme Techniques, Immunoglobulin G (analysis), Immunoglobulin M (analysis), Microfilariae (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antibodies, Helminth, Immunoglobulin G, Immunoglobulin M.
- chemical , immunology : Antigens, Surface.
- immunology : Elephantiasis, Filarial, Microfilariae, Wuchereria bancrofti.
- Animals, Fluorescent Antibody Technique, Hot Temperature, Humans, Immunoenzyme Techniques.
Abstract
Antibodies directed towards the sheaths of microfilariae have been implicated in the elimination of circulating microfilariae, both in experimental and human filariasis. In the present study antisheath antibodies have been detected in human sera by indirect immunoperoxidase assay (IPA) using fixed Wuchereria bancrofti microfilariae as antigen. One hundred and eighteen sera collected from an area endemic for Bancroftian filariasis were tested. While 80% of sera from microfilariae carriers had no demonstrable antisheath antibodies, more than 80% of amicrofilaraemic samples (chronic filariasis cases and endemic normals) had antisheath antibodies. The antibody activity was found in IgG, IgM and also IgE isotypes. IgG subclass typing with monospecific antisera revealed significantly higher antisheath activity in IgG2 in comparison with other IgG subclasses. The determinants on sheathed microfilariae reacting with antisheath antibodies were found to be thermostable (100 degrees C for 30 minutes), resistant to protease treatment and significantly sensitive to sodium periodate treatment, indicating the possible role of carbohydrate moieties in eliciting protective antisheath antibodies in Bancroftian filariasis.
PubMed: 2076039
Affiliations:
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Ravindran</name><affiliation><nlm:affiliation>Regional Medical Research Centre, (Indian Council of Medical Research), Bhubaneswar.</nlm:affiliation><wicri:noCountry code="subField">Bhubaneswar</wicri:noCountry></affiliation></author><author><name sortKey="Satapathy, A K" sort="Satapathy, A K" uniqKey="Satapathy A" first="A K" last="Satapathy">A K Satapathy</name></author><author><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name></author><author><name sortKey="Pattnaik, N M" sort="Pattnaik, N M" uniqKey="Pattnaik N" first="N M" last="Pattnaik">N M Pattnaik</name></author><author><name sortKey="Subramanyam, V R" sort="Subramanyam, V R" uniqKey="Subramanyam V" first="V R" last="Subramanyam">V R Subramanyam</name></author></analytic><series><title level="j">Annals of tropical medicine and parasitology</title><idno type="ISSN">0003-4983</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Antigens, Surface (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Fluorescent Antibody Technique</term><term>Hot Temperature</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin M (analysis)</term><term>Microfilariae (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (analyse)</term><term>Antigènes de surface (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Immunoglobuline G (analyse)</term><term>Immunoglobuline M (analyse)</term><term>Microfilaria (immunologie)</term><term>Technique d'immunofluorescence</term><term>Techniques immunoenzymatiques</term><term>Température élevée</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Surface</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes de surface</term><term>Filariose lymphatique</term><term>Microfilaria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fluorescent Antibody Technique</term><term>Hot Temperature</term><term>Humans</term><term>Immunoenzyme Techniques</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Technique d'immunofluorescence</term><term>Techniques immunoenzymatiques</term><term>Température élevée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antibodies directed towards the sheaths of microfilariae have been implicated in the elimination of circulating microfilariae, both in experimental and human filariasis. In the present study antisheath antibodies have been detected in human sera by indirect immunoperoxidase assay (IPA) using fixed Wuchereria bancrofti microfilariae as antigen. One hundred and eighteen sera collected from an area endemic for Bancroftian filariasis were tested. While 80% of sera from microfilariae carriers had no demonstrable antisheath antibodies, more than 80% of amicrofilaraemic samples (chronic filariasis cases and endemic normals) had antisheath antibodies. The antibody activity was found in IgG, IgM and also IgE isotypes. IgG subclass typing with monospecific antisera revealed significantly higher antisheath activity in IgG2 in comparison with other IgG subclasses. The determinants on sheathed microfilariae reacting with antisheath antibodies were found to be thermostable (100 degrees C for 30 minutes), resistant to protease treatment and significantly sensitive to sodium periodate treatment, indicating the possible role of carbohydrate moieties in eliciting protective antisheath antibodies in Bancroftian filariasis.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name><name sortKey="Pattnaik, N M" sort="Pattnaik, N M" uniqKey="Pattnaik N" first="N M" last="Pattnaik">N M Pattnaik</name><name sortKey="Ravindran, B" sort="Ravindran, B" uniqKey="Ravindran B" first="B" last="Ravindran">B. Ravindran</name><name sortKey="Satapathy, A K" sort="Satapathy, A K" uniqKey="Satapathy A" first="A K" last="Satapathy">A K Satapathy</name><name sortKey="Subramanyam, V R" sort="Subramanyam, V R" uniqKey="Subramanyam V" first="V R" last="Subramanyam">V R Subramanyam</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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