LymphedemaV1, Main, Exploration, bibRecord, 00DA38

Diethylcarbamazine in the control of bancroftian filariasis in the highly endemic Ok Tedi area of Papua New Guinea: phase 1.

Identifieur interne : 00DA38 ( Main/Exploration ); précédent : 00DA37; suivant : 00DA39

Diethylcarbamazine in the control of bancroftian filariasis in the highly endemic Ok Tedi area of Papua New Guinea: phase 1.

Auteurs : G J Schuurkamp [Papouasie-Nouvelle-Guinée] ; R K Kereu ; P K Bulungol

Source :

Papua and New Guinea medical journal [ 0031-1480 ] ; 1990.

RBID : pubmed:2238834

Descripteurs français

KwdFr :
- Adulte, Animaux, Contrôle des maladies contagieuses, Diéthylcarbamazine (pharmacologie), Diéthylcarbamazine (usage thérapeutique), Femelle, Filariose lymphatique (), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Incidence, Mâle, Nouvelle-Guinée, Paludisme (), Paludisme (épidémiologie), Prévalence, Vecteurs insectes (), Wuchereria bancrofti.
MESH :
- pharmacologie : Diéthylcarbamazine.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine.
- épidémiologie : Filariose lymphatique, Paludisme.
- Adulte, Animaux, Contrôle des maladies contagieuses, Femelle, Filariose lymphatique, Humains, Incidence, Mâle, Nouvelle-Guinée, Paludisme, Prévalence, Vecteurs insectes, Wuchereria bancrofti.

English descriptors

KwdEn :
- Adult, Animals, Communicable Disease Control, Diethylcarbamazine (pharmacology), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Female, Humans, Incidence, Insect Vectors (drug effects), Malaria (epidemiology), Malaria (prevention & control), Male, New Guinea, Prevalence, Wuchereria bancrofti.
MESH :
- chemical , pharmacology : Diethylcarbamazine.
- chemical , therapeutic use : Diethylcarbamazine.
- geographic : New Guinea.
- drug effects : Insect Vectors.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial, Malaria.
- prevention & control : Elephantiasis, Filarial, Malaria.
- Adult, Animals, Communicable Disease Control, Female, Humans, Incidence, Male, Prevalence, Wuchereria bancrofti.

Abstract

The effects of a well-spaced diethylcarbamazine (DEC) mass drug application in areas highly endemic for Wuchereria bancrofti in Papua New Guinea are not known. In 1986 a semi-annual single-dose 6 mg/kg body weight administration of DEC was initiated in the Ok Tedi area of Western Province, Papua New Guinea. The rate of bancroftian filariasis in the area was 39%. Within two years the rate of detectable microfilaraemia was reduced from 31% to 11% in the treated group. The mean blood density of the parasite was reduced from 79 to 19 microfilariae per 20 microliters. A survey of untreated villages in the immediate area (not surveyed before 1988) showed a filariasis rate of 39%. A 14-fold difference in the total microfilaraemia count was noted between the two groups when 1988 data were compared. A reduction in the annual rate of filariasis may be monitored through a well-established passive case detection program for malaria. The DEC treatment program was well accepted despite side-effects encountered in 20% of the treated population early on in the program. The success of the 2-year Phase 1 program has expanded into an annual single-dose administration of DEC over a larger area.

PubMed: 2238834

Affiliations:

Papouasie-Nouvelle-Guinée

Le document en format XML

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Diethylcarbamazine in the control of bancroftian filariasis in the highly endemic Ok Tedi area of Papua New Guinea: phase 1.

Diethylcarbamazine in the control of bancroftian filariasis in the highly endemic Ok Tedi area of Papua New Guinea: phase 1.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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