In vivo effect of benzothiazole and amoscanate derivatives on the fine structure of adult Brugia spp. and Litomosoides carinii.
Identifieur interne : 00DA13 ( Main/Exploration ); précédent : 00DA12; suivant : 00DA14In vivo effect of benzothiazole and amoscanate derivatives on the fine structure of adult Brugia spp. and Litomosoides carinii.
Auteurs : M. Franz [Allemagne] ; H. Zahner ; H. Mehlhorn ; H P StriebelSource :
- Parasitology research [ 0932-0113 ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Antihelminthiques (pharmacologie), Benzothiazoles, Brugia (), Brugia (ultrastructure), Diphénylamine (analogues et dérivés), Diphénylamine (pharmacologie), Diphénylamine (usage thérapeutique), Dérivés de l'aniline (pharmacologie), Femelle, Filaricides (pharmacologie), Filaricides (usage thérapeutique), Filarioidea (), Filarioidea (ultrastructure), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filarioses (parasitologie), Filarioses (traitement médicamenteux), Isothiocyanates, Microscopie électronique, Muridae, Pipérazines (pharmacologie), Pipérazines (usage thérapeutique), Thiazoles (pharmacologie), Thiazoles (usage thérapeutique), Thiocyanates (pharmacologie), Thiocyanates (usage thérapeutique).
- MESH :
- analogues et dérivés : Diphénylamine.
- parasitologie : Filariose lymphatique, Filarioses.
- pharmacologie : Antihelminthiques, Diphénylamine, Dérivés de l'aniline, Filaricides, Pipérazines, Thiazoles, Thiocyanates.
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Brugia, Diphénylamine, Filaricides, Filarioidea, Pipérazines, Thiazoles, Thiocyanates.
- Animaux, Benzothiazoles, Brugia, Femelle, Filarioidea, Isothiocyanates, Microscopie électronique, Muridae.
English descriptors
- KwdEn :
- Aniline Compounds (pharmacology), Animals, Anthelmintics (pharmacology), Benzothiazoles, Brugia (drug effects), Brugia (ultrastructure), Diphenylamine (analogs & derivatives), Diphenylamine (pharmacology), Diphenylamine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Female, Filariasis (drug therapy), Filariasis (parasitology), Filaricides (pharmacology), Filaricides (therapeutic use), Filarioidea (drug effects), Filarioidea (ultrastructure), Isothiocyanates, Microscopy, Electron, Muridae, Piperazines (pharmacology), Piperazines (therapeutic use), Thiazoles (pharmacology), Thiazoles (therapeutic use), Thiocyanates (pharmacology), Thiocyanates (therapeutic use).
- MESH :
- chemical , analogs & derivatives : Diphenylamine.
- chemical , pharmacology : Aniline Compounds, Anthelmintics, Diphenylamine, Filaricides, Piperazines, Thiazoles, Thiocyanates.
- drug effects : Brugia, Filarioidea.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- parasitology : Elephantiasis, Filarial, Filariasis.
- chemical , therapeutic use : Diphenylamine, Filaricides, Piperazines, Thiazoles, Thiocyanates.
- ultrastructure : Brugia, Filarioidea.
- Animals, Benzothiazoles, Female, Isothiocyanates, Microscopy, Electron, Muridae.
Abstract
Alterations in the fine structures of female Brugia spp. and Litomosoides carinii were investigated after in vivo treatment with curative doses of 4 compounds: CGP 20376 [2-tert-butyl-benzothiazole-5-methoxy-6-dithiocarbamic-S-(2- carboxyethyl)-ester], CGP 21833 (2-tert-butyl-benzothiazole-5-methyl-6- N-methylamino-piperazinylthiocarbonylamide), CGP 6140 [4-Nitro-4'-(N-methyl-piperazinylthiocarbonylamido)-diphenylamine] and amoscanate (4-isothiocyanato-4'-nitrodiphenylamine). All compounds caused early alterations in the somatic muscle cells. These alterations usually appeared within 24 h after treatment; they occurred later only after treatment of L. carinii with amoscanate. In Brugia spp., swelling of the muscle cells occurred in which the glycogen deposits considerably increased in size. The electron density of the cytoplasm surrounding the myofilaments in the fibrillar portion of the muscle cells increased, and light zones appeared between the fibrils. The muscle cell mitochondria swelled, particularly their inner matrix, which became more electron-lucent, with some dense spots. In L. carinii the muscle cells were not increased in size, but their mitochondria were considerably swollen before disintegration; this was followed by disintegration of the myofilaments and vacuolization of the cytoplasm. Vacuolization before mitochondrial swelling was observed only after treatment with CGP 6140. Other tissues of this species were not altered before the 2nd day after treatment. In Brugia spp., electron-lucent appeared in the hypodermis either simultaneously with the alterations in the muscle cells or a few hours later. At 24 h after treatment with amoscanate, blebs were formed on the luminal side of the intestinal membrane.
PubMed: 2352916
Affiliations:
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Le document en format XML
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Mehlhorn</name></author><author><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2352916</idno><idno type="pmid">2352916</idno><idno type="wicri:Area/PubMed/Corpus">005E38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005E38</idno><idno type="wicri:Area/PubMed/Curation">005E38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005E38</idno><idno type="wicri:Area/PubMed/Checkpoint">005E38</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005E38</idno><idno type="wicri:Area/Ncbi/Merge">005750</idno><idno type="wicri:Area/Ncbi/Curation">005750</idno><idno type="wicri:Area/Ncbi/Checkpoint">005750</idno><idno type="wicri:doubleKey">0932-0113:1990:Franz M:in:vivo:effect</idno><idno type="wicri:Area/Main/Merge">00E609</idno><idno type="wicri:Area/Main/Curation">00DA13</idno><idno type="wicri:Area/Main/Exploration">00DA13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vivo effect of benzothiazole and amoscanate derivatives on the fine structure of adult Brugia spp. and Litomosoides carinii.</title><author><name sortKey="Franz, M" sort="Franz, M" uniqKey="Franz M" first="M" last="Franz">M. Franz</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Spezielle Zoologie und Parasitologie, Ruhr-Universität, Bochum, Federal Republic of Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Spezielle Zoologie und Parasitologie, Ruhr-Universität, Bochum</wicri:regionArea><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Zahner, H" sort="Zahner, H" uniqKey="Zahner H" first="H" last="Zahner">H. Zahner</name></author><author><name sortKey="Mehlhorn, H" sort="Mehlhorn, H" uniqKey="Mehlhorn H" first="H" last="Mehlhorn">H. Mehlhorn</name></author><author><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name></author></analytic><series><title level="j">Parasitology research</title><idno type="ISSN">0932-0113</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aniline Compounds (pharmacology)</term><term>Animals</term><term>Anthelmintics (pharmacology)</term><term>Benzothiazoles</term><term>Brugia (drug effects)</term><term>Brugia (ultrastructure)</term><term>Diphenylamine (analogs & derivatives)</term><term>Diphenylamine (pharmacology)</term><term>Diphenylamine (therapeutic use)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Filariasis (drug therapy)</term><term>Filariasis (parasitology)</term><term>Filaricides (pharmacology)</term><term>Filaricides (therapeutic use)</term><term>Filarioidea (drug effects)</term><term>Filarioidea (ultrastructure)</term><term>Isothiocyanates</term><term>Microscopy, Electron</term><term>Muridae</term><term>Piperazines (pharmacology)</term><term>Piperazines (therapeutic use)</term><term>Thiazoles (pharmacology)</term><term>Thiazoles (therapeutic use)</term><term>Thiocyanates (pharmacology)</term><term>Thiocyanates (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antihelminthiques (pharmacologie)</term><term>Benzothiazoles</term><term>Brugia ()</term><term>Brugia (ultrastructure)</term><term>Diphénylamine (analogues et dérivés)</term><term>Diphénylamine (pharmacologie)</term><term>Diphénylamine (usage thérapeutique)</term><term>Dérivés de l'aniline (pharmacologie)</term><term>Femelle</term><term>Filaricides (pharmacologie)</term><term>Filaricides (usage thérapeutique)</term><term>Filarioidea ()</term><term>Filarioidea (ultrastructure)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (parasitologie)</term><term>Filarioses (traitement médicamenteux)</term><term>Isothiocyanates</term><term>Microscopie électronique</term><term>Muridae</term><term>Pipérazines (pharmacologie)</term><term>Pipérazines (usage thérapeutique)</term><term>Thiazoles (pharmacologie)</term><term>Thiazoles (usage thérapeutique)</term><term>Thiocyanates (pharmacologie)</term><term>Thiocyanates (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Diphenylamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aniline 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Electron</term><term>Muridae</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Benzothiazoles</term><term>Brugia</term><term>Femelle</term><term>Filarioidea</term><term>Isothiocyanates</term><term>Microscopie électronique</term><term>Muridae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alterations in the fine structures of female Brugia spp. and Litomosoides carinii were investigated after in vivo treatment with curative doses of 4 compounds: CGP 20376 [2-tert-butyl-benzothiazole-5-methoxy-6-dithiocarbamic-S-(2- carboxyethyl)-ester], CGP 21833 (2-tert-butyl-benzothiazole-5-methyl-6- N-methylamino-piperazinylthiocarbonylamide), CGP 6140 [4-Nitro-4'-(N-methyl-piperazinylthiocarbonylamido)-diphenylamine] and amoscanate (4-isothiocyanato-4'-nitrodiphenylamine). All compounds caused early alterations in the somatic muscle cells. These alterations usually appeared within 24 h after treatment; they occurred later only after treatment of L. carinii with amoscanate. In Brugia spp., swelling of the muscle cells occurred in which the glycogen deposits considerably increased in size. The electron density of the cytoplasm surrounding the myofilaments in the fibrillar portion of the muscle cells increased, and light zones appeared between the fibrils. The muscle cell mitochondria swelled, particularly their inner matrix, which became more electron-lucent, with some dense spots. In L. carinii the muscle cells were not increased in size, but their mitochondria were considerably swollen before disintegration; this was followed by disintegration of the myofilaments and vacuolization of the cytoplasm. Vacuolization before mitochondrial swelling was observed only after treatment with CGP 6140. Other tissues of this species were not altered before the 2nd day after treatment. In Brugia spp., electron-lucent appeared in the hypodermis either simultaneously with the alterations in the muscle cells or a few hours later. At 24 h after treatment with amoscanate, blebs were formed on the luminal side of the intestinal membrane.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Mehlhorn, H" sort="Mehlhorn, H" uniqKey="Mehlhorn H" first="H" last="Mehlhorn">H. Mehlhorn</name><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name><name sortKey="Zahner, H" sort="Zahner, H" uniqKey="Zahner H" first="H" last="Zahner">H. Zahner</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Franz, M" sort="Franz, M" uniqKey="Franz M" first="M" last="Franz">M. Franz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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