Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome
Identifieur interne : 00D753 ( Main/Exploration ); précédent : 00D752; suivant : 00D754Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome
Auteurs : Lars Gunnar Kindblom [Suède] ; Göran Stenman [Suède] ; Lennart Angervall [Suède]Source :
- Virchows Archiv A [ 0174-7398 ] ; 1991-09-01.
Descripteurs français
- KwdFr :
- Adulte, Cartographie chromosomique, Caryotypage, Complications postopératoires, Femelle, Humains, Hémangiosarcome (anatomopathologie), Hémangiosarcome (métabolisme), Immunohistochimie, Lymphoedème (), Lymphoedème (anatomopathologie), Lymphoedème (étiologie), Mastectomie (effets indésirables), Microscopie électronique, Syndrome, Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (métabolisme).
- MESH :
- anatomopathologie : Hémangiosarcome, Lymphoedème, Tumeurs cutanées.
- effets indésirables : Mastectomie.
- métabolisme : Hémangiosarcome, Tumeurs cutanées.
- étiologie : Lymphoedème.
- Adulte, Cartographie chromosomique, Caryotypage, Complications postopératoires, Femelle, Humains, Immunohistochimie, Lymphoedème, Microscopie électronique, Syndrome.
English descriptors
- KwdEn :
- Adult, Chromosome Mapping, Female, Hemangiosarcoma (metabolism), Hemangiosarcoma (pathology), Humans, Immunohistochemistry, Karyotyping, Lymphedema (complications), Lymphedema (etiology), Lymphedema (pathology), Mastectomy (adverse effects), Microscopy, Electron, Postoperative Complications, Skin Neoplasms (metabolism), Skin Neoplasms (pathology), Syndrome.
- MESH :
- adverse effects : Mastectomy.
- complications : Lymphedema.
- etiology : Lymphedema.
- metabolism : Hemangiosarcoma, Skin Neoplasms.
- pathology : Hemangiosarcoma, Lymphedema, Skin Neoplasms.
- Adult, Chromosome Mapping, Female, Humans, Immunohistochemistry, Karyotyping, Microscopy, Electron, Postoperative Complications, Syndrome.
Abstract
Summary: A morphological and cytogenetic analysis of a multifocal angiosarcoma in a typical case of Stewart-Treves syndrome is reported. The morphological analysis indicated differentiation along both blood and lymph vessel endothelium lines. By light and electron microscopy there were areas with well-developed erythrocyte-containing, capillary-like vessels and poorly differentiated areas with abortive vascular formations. In these the endothelium revealed immunoreactivity to factor VIII RAg, binding ofUlex europaeus I andPsophocarpus tetragonolobus agglutinin lectins, Weibel-Palade bodies ultrastructurally and presented a continuous enclosing external lamina and immunoreactivity for laminin and collagen IV, all features of blood-vessel differentiation. There were also lymphangioma-like areas as well as poorly differentiated areas where the immunohistochemical, lectin-binding and ultrastructural features were compatible with a lymph vessel differentiation. Cytogenetic analysis of cultured tumour cells revealed chromosome counts in the diploid region. About 40% of the cells analysed had a normal diploid karyotype. The remaining cells showed a multitude of mainly nonclonal structural alterations; 17 unique marker types resulting from different translocations and deletions were observed. There were also a few cells with clonal numerical deviations showing monosomy 22, monosomy X and trisomy 2 respectively. It is of interest that the losses of chromosome 22 and the X chromosome also have been observed in Kaposi's sarcoma and that the PD-ECGF gene, a novel angiogenetic factor, has been mapped to chromosome 22.
Url:
DOI: 10.1007/BF01605079
Affiliations:
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qualifier="pathology" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphedema</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Chromosome Mapping</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Karyotyping</term><term>Microscopy, Electron</term><term>Postoperative Complications</term><term>Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Cartographie chromosomique</term><term>Caryotypage</term><term>Complications postopératoires</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Lymphoedème</term><term>Microscopie électronique</term><term>Syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: A morphological and cytogenetic analysis of a multifocal angiosarcoma in a typical case of Stewart-Treves syndrome is reported. The morphological analysis indicated differentiation along both blood and lymph vessel endothelium lines. By light and electron microscopy there were areas with well-developed erythrocyte-containing, capillary-like vessels and poorly differentiated areas with abortive vascular formations. In these the endothelium revealed immunoreactivity to factor VIII RAg, binding ofUlex europaeus I andPsophocarpus tetragonolobus agglutinin lectins, Weibel-Palade bodies ultrastructurally and presented a continuous enclosing external lamina and immunoreactivity for laminin and collagen IV, all features of blood-vessel differentiation. There were also lymphangioma-like areas as well as poorly differentiated areas where the immunohistochemical, lectin-binding and ultrastructural features were compatible with a lymph vessel differentiation. Cytogenetic analysis of cultured tumour cells revealed chromosome counts in the diploid region. About 40% of the cells analysed had a normal diploid karyotype. The remaining cells showed a multitude of mainly nonclonal structural alterations; 17 unique marker types resulting from different translocations and deletions were observed. There were also a few cells with clonal numerical deviations showing monosomy 22, monosomy X and trisomy 2 respectively. It is of interest that the losses of chromosome 22 and the X chromosome also have been observed in Kaposi's sarcoma and that the PD-ECGF gene, a novel angiogenetic factor, has been mapped to chromosome 22.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Kindblom, Lars Gunnar" sort="Kindblom, Lars Gunnar" uniqKey="Kindblom L" first="Lars Gunnar" last="Kindblom">Lars Gunnar Kindblom</name></noRegion><name sortKey="Angervall, Lennart" sort="Angervall, Lennart" uniqKey="Angervall L" first="Lennart" last="Angervall">Lennart Angervall</name><name sortKey="Stenman, Goran" sort="Stenman, Goran" uniqKey="Stenman G" first="Göran" last="Stenman">Göran Stenman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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