Normal wound healing of the paranasal sinuses: Clinical and experimental investigations
Identifieur interne : 00D747 ( Main/Exploration ); précédent : 00D746; suivant : 00D748Normal wound healing of the paranasal sinuses: Clinical and experimental investigations
Auteurs : W. 0hosemann [Allemagne] ; M. E. Wigand [Allemagne] ; U. Göde [Allemagne] ; F. Linger [Allemagne] ; I. Dunker [Allemagne]Source :
- European Archives of Oto-Rhino-Laryngology [ 0937-4477 ] ; 1991-10-01.
Abstract
Summary: Twenty-two patients underwent partial or complete ethmoidectomies and were subjected to standardized postoperative follow-ups including endoscopic photography of healing tissues. Sequential biopsies were also taken from the regenerating mucosa and compared with endoscopic findings. On this basis wound healing could be divided into four different phases, allowing for the diagnosis of healing disturbances and clinical planning of stage-dependent therapy. Additionally, a model of wound healing in the maxillary antrum of the rabbit was developed for better understanding the clinical observations. Regeneration of standardized mucosal defects was studied with three-dimensional histomorphological analysis. Circular wounds were found to regenerate concentrically, with wound closure starting by epithelial migration. Within 120 h, granulation tissue covering the wound surface started to become hyperplastic and bone apposition occurred with the formation of osteoid. The systemic application of prednisolone (2 mg/ kg per day i.m.) and topical 5% dexpanthenol ointment resulted in an acceleration of late epithelial wound closure together with a reduction in hyperplastic granulation tissue. Local applications of “epidermal growth factor” had no significant effect.
Url:
DOI: 10.1007/BF01463560
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001309
- to stream Istex, to step Curation: 001309
- to stream Istex, to step Checkpoint: 005333
- to stream Main, to step Merge: 00E308
- to stream Main, to step Curation: 00D747
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Normal wound healing of the paranasal sinuses: Clinical and experimental investigations</title><author><name sortKey="0hosemann, W" sort="0hosemann, W" uniqKey="0hosemann W" first="W." last="0hosemann">W. 0hosemann</name></author><author><name sortKey="Wigand, M E" sort="Wigand, M E" uniqKey="Wigand M" first="M. E." last="Wigand">M. E. Wigand</name></author><author><name sortKey="Gode, U" sort="Gode, U" uniqKey="Gode U" first="U." last="Göde">U. Göde</name></author><author><name sortKey="Linger, F" sort="Linger, F" uniqKey="Linger F" first="F." last="Linger">F. Linger</name></author><author><name sortKey="Dunker, I" sort="Dunker, I" uniqKey="Dunker I" first="I." last="Dunker">I. Dunker</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:293845C59C92D995BFB6C8109ADE30E27B67443C</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1007/BF01463560</idno><idno type="url">https://api.istex.fr/document/293845C59C92D995BFB6C8109ADE30E27B67443C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001309</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001309</idno><idno type="wicri:Area/Istex/Curation">001309</idno><idno type="wicri:Area/Istex/Checkpoint">005333</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">005333</idno><idno type="wicri:doubleKey">0937-4477:1991:0hosemann W:normal:wound:healing</idno><idno type="wicri:Area/Main/Merge">00E308</idno><idno type="wicri:Area/Main/Curation">00D747</idno><idno type="wicri:Area/Main/Exploration">00D747</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Normal wound healing of the paranasal sinuses: Clinical and experimental investigations</title><author><name sortKey="0hosemann, W" sort="0hosemann, W" uniqKey="0hosemann W" first="W." last="0hosemann">W. 0hosemann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>NT Department, University of Erlangen-Nürnberg, Waldstrasse 1, W-8520, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Wigand, M E" sort="Wigand, M E" uniqKey="Wigand M" first="M. E." last="Wigand">M. E. Wigand</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>NT Department, University of Erlangen-Nürnberg, Waldstrasse 1, W-8520, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Gode, U" sort="Gode, U" uniqKey="Gode U" first="U." last="Göde">U. Göde</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>NT Department, University of Erlangen-Nürnberg, Waldstrasse 1, W-8520, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Linger, F" sort="Linger, F" uniqKey="Linger F" first="F." last="Linger">F. Linger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>NT Department, University of Erlangen-Nürnberg, Waldstrasse 1, W-8520, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Dunker, I" sort="Dunker, I" uniqKey="Dunker I" first="I." last="Dunker">I. Dunker</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>NT Department, University of Erlangen-Nürnberg, Waldstrasse 1, W-8520, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Archives of Oto-Rhino-Laryngology</title><title level="j" type="abbrev">Eur Arch Otorhinolaryngol</title><idno type="ISSN">0937-4477</idno><idno type="eISSN">1434-4726</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-10-01">1991-10-01</date><biblScope unit="volume">248</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="390">390</biblScope><biblScope unit="page" to="394">394</biblScope></imprint><idno type="ISSN">0937-4477</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0937-4477</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Twenty-two patients underwent partial or complete ethmoidectomies and were subjected to standardized postoperative follow-ups including endoscopic photography of healing tissues. Sequential biopsies were also taken from the regenerating mucosa and compared with endoscopic findings. On this basis wound healing could be divided into four different phases, allowing for the diagnosis of healing disturbances and clinical planning of stage-dependent therapy. Additionally, a model of wound healing in the maxillary antrum of the rabbit was developed for better understanding the clinical observations. Regeneration of standardized mucosal defects was studied with three-dimensional histomorphological analysis. Circular wounds were found to regenerate concentrically, with wound closure starting by epithelial migration. Within 120 h, granulation tissue covering the wound surface started to become hyperplastic and bone apposition occurred with the formation of osteoid. The systemic application of prednisolone (2 mg/ kg per day i.m.) and topical 5% dexpanthenol ointment resulted in an acceleration of late epithelial wound closure together with a reduction in hyperplastic granulation tissue. Local applications of “epidermal growth factor” had no significant effect.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Moyenne-Franconie</li></region><settlement><li>Erlangen</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="0hosemann, W" sort="0hosemann, W" uniqKey="0hosemann W" first="W." last="0hosemann">W. 0hosemann</name></region><name sortKey="Dunker, I" sort="Dunker, I" uniqKey="Dunker I" first="I." last="Dunker">I. Dunker</name><name sortKey="Gode, U" sort="Gode, U" uniqKey="Gode U" first="U." last="Göde">U. Göde</name><name sortKey="Linger, F" sort="Linger, F" uniqKey="Linger F" first="F." last="Linger">F. Linger</name><name sortKey="Wigand, M E" sort="Wigand, M E" uniqKey="Wigand M" first="M. E." last="Wigand">M. E. Wigand</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00D747 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00D747 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:293845C59C92D995BFB6C8109ADE30E27B67443C
|texte= Normal wound healing of the paranasal sinuses: Clinical and experimental investigations
}}
| This area was generated with Dilib version V0.6.31. |  |