Complications following external beam radiation therapy for prostate cancer: an analysis of patients treated with and without staging pelvic lymphadenectomy.
Identifieur interne : 00D573 ( Main/Exploration ); précédent : 00D572; suivant : 00D574Complications following external beam radiation therapy for prostate cancer: an analysis of patients treated with and without staging pelvic lymphadenectomy.
Auteurs : F J Greskovich ; G K Zagars ; N E Sherman ; D E JohnsonSource :
- The Journal of urology [ 0022-5347 ] ; 1991.
Descripteurs français
- KwdFr :
- Adénocarcinome (), Adénocarcinome (anatomopathologie), Adénocarcinome (mortalité), Adénocarcinome (radiothérapie), Association thérapeutique, Dosimétrie en radiothérapie, Humains, Lymphadénectomie, Lésions radio-induites (anatomopathologie), Lésions radio-induites (étiologie), Maladies du rectum (étiologie), Maladies urologiques (étiologie), Mâle, Pelvis, Prostatectomie, Radiothérapie de haute énergie (effets indésirables), Sujet âgé, Tumeurs de la prostate (), Tumeurs de la prostate (anatomopathologie), Tumeurs de la prostate (mortalité), Tumeurs de la prostate (radiothérapie).
- MESH :
- anatomopathologie : Adénocarcinome, Lésions radio-induites, Tumeurs de la prostate.
- effets indésirables : Radiothérapie de haute énergie.
- mortalité : Adénocarcinome, Tumeurs de la prostate.
- radiothérapie : Adénocarcinome, Tumeurs de la prostate.
- étiologie : Lésions radio-induites, Maladies du rectum, Maladies urologiques.
- Adénocarcinome, Association thérapeutique, Dosimétrie en radiothérapie, Humains, Lymphadénectomie, Mâle, Pelvis, Prostatectomie, Sujet âgé, Tumeurs de la prostate.
English descriptors
- KwdEn :
- Adenocarcinoma (mortality), Adenocarcinoma (pathology), Adenocarcinoma (radiotherapy), Adenocarcinoma (surgery), Aged, Combined Modality Therapy, Humans, Lymph Node Excision, Male, Pelvis, Prostatectomy, Prostatic Neoplasms (mortality), Prostatic Neoplasms (pathology), Prostatic Neoplasms (radiotherapy), Prostatic Neoplasms (surgery), Radiation Injuries (etiology), Radiation Injuries (pathology), Radiotherapy Dosage, Radiotherapy, High-Energy (adverse effects), Rectal Diseases (etiology), Urologic Diseases (etiology).
- MESH :
- adverse effects : Radiotherapy, High-Energy.
- etiology : Radiation Injuries, Rectal Diseases, Urologic Diseases.
- mortality : Adenocarcinoma, Prostatic Neoplasms.
- pathology : Adenocarcinoma, Prostatic Neoplasms, Radiation Injuries.
- radiotherapy : Adenocarcinoma, Prostatic Neoplasms.
- surgery : Adenocarcinoma, Prostatic Neoplasms.
- Aged, Combined Modality Therapy, Humans, Lymph Node Excision, Male, Pelvis, Prostatectomy, Radiotherapy Dosage.
Abstract
We reviewed the treatment morbidity associated with definitive high energy external beam radiotherapy in 289 consecutive patients with clinically localized prostate cancer (stages A2 to C) treated from 1984 to 1988 inclusively. All patients were treated with 18 mv. photon beams via a 4-field box technique. Radiation doses ranged from 5,858 to 6,900 cGy., with a mean dose of 6,456 cGy. and a median dose of 6,400 cGy. A total of 65 patients underwent extraperitoneal pelvic staging lymphadenectomy before radiotherapy. Complications noted in 42 patients were mild (generally trivial) in 23 and moderate in 19 (6.6%). There were no severe complications. The actuarial incidence of moderate complications was 9% at 5 years. Only 6 patients experienced symptoms for longer than 6 months. The risk of complications was not increased in patients who had undergone prior lymph node dissection, and only 2 of 65 had mild lymphedema, which resolved in both cases. We conclude that high energy external beam radiation for prostate cancer can be delivered with a low risk of serious complications, even in patients who have undergone extraperitoneal staging pelvic lymphadenectomy, provided the patients are treated to limited fields with high energy photons and at doses limited to 6,800 cGy. or less.
PubMed: 1908530
Affiliations:
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Johnson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1908530</idno><idno type="pmid">1908530</idno><idno type="wicri:Area/PubMed/Corpus">005A82</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005A82</idno><idno type="wicri:Area/PubMed/Curation">005A82</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005A82</idno><idno type="wicri:Area/PubMed/Checkpoint">005A82</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005A82</idno><idno type="wicri:Area/Ncbi/Merge">003125</idno><idno type="wicri:Area/Ncbi/Curation">003125</idno><idno type="wicri:Area/Ncbi/Checkpoint">003125</idno><idno type="wicri:doubleKey">0022-5347:1991:Greskovich F:complications:following:external</idno><idno type="wicri:Area/Main/Merge">00E115</idno><idno type="wicri:Area/Main/Curation">00D573</idno><idno 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last="Johnson">D E Johnson</name></author></analytic><series><title level="j">The Journal of urology</title><idno type="ISSN">0022-5347</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (mortality)</term><term>Adenocarcinoma (pathology)</term><term>Adenocarcinoma (radiotherapy)</term><term>Adenocarcinoma (surgery)</term><term>Aged</term><term>Combined Modality Therapy</term><term>Humans</term><term>Lymph Node Excision</term><term>Male</term><term>Pelvis</term><term>Prostatectomy</term><term>Prostatic Neoplasms (mortality)</term><term>Prostatic Neoplasms (pathology)</term><term>Prostatic Neoplasms (radiotherapy)</term><term>Prostatic Neoplasms (surgery)</term><term>Radiation Injuries (etiology)</term><term>Radiation Injuries (pathology)</term><term>Radiotherapy Dosage</term><term>Radiotherapy, High-Energy (adverse effects)</term><term>Rectal Diseases (etiology)</term><term>Urologic Diseases (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénocarcinome ()</term><term>Adénocarcinome (anatomopathologie)</term><term>Adénocarcinome (mortalité)</term><term>Adénocarcinome (radiothérapie)</term><term>Association thérapeutique</term><term>Dosimétrie en radiothérapie</term><term>Humains</term><term>Lymphadénectomie</term><term>Lésions radio-induites (anatomopathologie)</term><term>Lésions radio-induites (étiologie)</term><term>Maladies du rectum (étiologie)</term><term>Maladies urologiques (étiologie)</term><term>Mâle</term><term>Pelvis</term><term>Prostatectomie</term><term>Radiothérapie de haute énergie (effets indésirables)</term><term>Sujet âgé</term><term>Tumeurs de la prostate ()</term><term>Tumeurs de la prostate (anatomopathologie)</term><term>Tumeurs de la prostate (mortalité)</term><term>Tumeurs de la prostate (radiothérapie)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy, High-Energy</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Adénocarcinome</term><term>Lésions radio-induites</term><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Radiothérapie de haute énergie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Radiation Injuries</term><term>Rectal Diseases</term><term>Urologic Diseases</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Adenocarcinoma</term><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenocarcinoma</term><term>Prostatic Neoplasms</term><term>Radiation Injuries</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Adenocarcinoma</term><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Adenocarcinoma</term><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lésions radio-induites</term><term>Maladies du rectum</term><term>Maladies urologiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Humans</term><term>Lymph Node Excision</term><term>Male</term><term>Pelvis</term><term>Prostatectomy</term><term>Radiotherapy Dosage</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adénocarcinome</term><term>Association thérapeutique</term><term>Dosimétrie en radiothérapie</term><term>Humains</term><term>Lymphadénectomie</term><term>Mâle</term><term>Pelvis</term><term>Prostatectomie</term><term>Sujet âgé</term><term>Tumeurs de la prostate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We reviewed the treatment morbidity associated with definitive high energy external beam radiotherapy in 289 consecutive patients with clinically localized prostate cancer (stages A2 to C) treated from 1984 to 1988 inclusively. All patients were treated with 18 mv. photon beams via a 4-field box technique. Radiation doses ranged from 5,858 to 6,900 cGy., with a mean dose of 6,456 cGy. and a median dose of 6,400 cGy. A total of 65 patients underwent extraperitoneal pelvic staging lymphadenectomy before radiotherapy. Complications noted in 42 patients were mild (generally trivial) in 23 and moderate in 19 (6.6%). There were no severe complications. The actuarial incidence of moderate complications was 9% at 5 years. Only 6 patients experienced symptoms for longer than 6 months. The risk of complications was not increased in patients who had undergone prior lymph node dissection, and only 2 of 65 had mild lymphedema, which resolved in both cases. We conclude that high energy external beam radiation for prostate cancer can be delivered with a low risk of serious complications, even in patients who have undergone extraperitoneal staging pelvic lymphadenectomy, provided the patients are treated to limited fields with high energy photons and at doses limited to 6,800 cGy. or less.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Greskovich, F J" sort="Greskovich, F J" uniqKey="Greskovich F" first="F J" last="Greskovich">F J Greskovich</name><name sortKey="Johnson, D E" sort="Johnson, D E" uniqKey="Johnson D" first="D E" last="Johnson">D E Johnson</name><name sortKey="Sherman, N E" sort="Sherman, N E" uniqKey="Sherman N" first="N E" last="Sherman">N E Sherman</name><name sortKey="Zagars, G K" sort="Zagars, G K" uniqKey="Zagars G" first="G K" last="Zagars">G K Zagars</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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