Immunoregulation in human lymphatic filariasis: the role of interleukin 10.
Identifieur interne : 00C295 ( Main/Exploration ); précédent : 00C294; suivant : 00C296Immunoregulation in human lymphatic filariasis: the role of interleukin 10.
Auteurs : S. Mahanty [États-Unis] ; T B NutmanSource :
- Parasite immunology [ 0141-9838 ] ; 1995.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Filariose lymphatique, Lymphocytes T.
- physiologie : Interféron gamma, Interleukine-10.
- Humains, Tolérance immunitaire.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Interferon-gamma, Interleukin-10.
- immunology : Elephantiasis, Filarial, T-Lymphocytes.
- Humans, Immune Tolerance.
Abstract
In humans with lymphatic filariasis microfilaremia is associated with a parasite antigen-specific hyporesponsiveness when assessed by cell proliferation and secretion of interleukin-2 and interferon-gamma. Hyporesponsiveness in these individuals is not only parasite antigen-specific but appears to be limited to Th1-type responses. Th2 mediated responses such as IL-5 secretion and IgE antibody production to parasite antigens are generally strong and usually no different than those seen in immunologically more reactive amicrofilaremic individuals with chronic lymphatic pathology. The mechanisms by which Th1 responses are inhibited have not yet been elucidated, but some studies suggest that down-regulatory cytokines such as IL-10 may be involved in this process. Mononuclear cells from microfilaremic individuals have been found to secrete greater quantities of IL-10 spontaneously and in response to parasite antigens. In this review, mechanisms by which IL-10 may be induced by the parasite and the mode by which IL-10 may regulate parasite antigen-specific Th1 responses in these individuals are discussed.
PubMed: 7501419
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 005365
- to stream PubMed, to step Curation: 005365
- to stream PubMed, to step Checkpoint: 005365
- to stream Ncbi, to step Merge: 00B080
- to stream Ncbi, to step Curation: 00B080
- to stream Ncbi, to step Checkpoint: 00B080
- to stream Main, to step Merge: 00CB89
- to stream Main, to step Curation: 00C295
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunoregulation in human lymphatic filariasis: the role of interleukin 10.</title><author><name sortKey="Mahanty, S" sort="Mahanty, S" uniqKey="Mahanty S" first="S" last="Mahanty">S. Mahanty</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425</wicri:regionArea><wicri:noRegion>Maryland 20892-0425</wicri:noRegion></affiliation></author><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7501419</idno><idno type="pmid">7501419</idno><idno type="wicri:Area/PubMed/Corpus">005365</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005365</idno><idno type="wicri:Area/PubMed/Curation">005365</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005365</idno><idno type="wicri:Area/PubMed/Checkpoint">005365</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005365</idno><idno type="wicri:Area/Ncbi/Merge">00B080</idno><idno type="wicri:Area/Ncbi/Curation">00B080</idno><idno type="wicri:Area/Ncbi/Checkpoint">00B080</idno><idno type="wicri:doubleKey">0141-9838:1995:Mahanty S:immunoregulation:in:human</idno><idno type="wicri:Area/Main/Merge">00CB89</idno><idno type="wicri:Area/Main/Curation">00C295</idno><idno type="wicri:Area/Main/Exploration">00C295</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immunoregulation in human lymphatic filariasis: the role of interleukin 10.</title><author><name sortKey="Mahanty, S" sort="Mahanty, S" uniqKey="Mahanty S" first="S" last="Mahanty">S. Mahanty</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425</wicri:regionArea><wicri:noRegion>Maryland 20892-0425</wicri:noRegion></affiliation></author><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Elephantiasis, Filarial (immunology)</term><term>Humans</term><term>Immune Tolerance</term><term>Interferon-gamma (physiology)</term><term>Interleukin-10 (physiology)</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Interféron gamma (physiologie)</term><term>Interleukine-10 (physiologie)</term><term>Lymphocytes T (immunologie)</term><term>Tolérance immunitaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Interferon-gamma</term><term>Interleukin-10</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Interféron gamma</term><term>Interleukine-10</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immune Tolerance</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Tolérance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In humans with lymphatic filariasis microfilaremia is associated with a parasite antigen-specific hyporesponsiveness when assessed by cell proliferation and secretion of interleukin-2 and interferon-gamma. Hyporesponsiveness in these individuals is not only parasite antigen-specific but appears to be limited to Th1-type responses. Th2 mediated responses such as IL-5 secretion and IgE antibody production to parasite antigens are generally strong and usually no different than those seen in immunologically more reactive amicrofilaremic individuals with chronic lymphatic pathology. The mechanisms by which Th1 responses are inhibited have not yet been elucidated, but some studies suggest that down-regulatory cytokines such as IL-10 may be involved in this process. Mononuclear cells from microfilaremic individuals have been found to secrete greater quantities of IL-10 spontaneously and in response to parasite antigens. In this review, mechanisms by which IL-10 may be induced by the parasite and the mode by which IL-10 may regulate parasite antigen-specific Th1 responses in these individuals are discussed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Mahanty, S" sort="Mahanty, S" uniqKey="Mahanty S" first="S" last="Mahanty">S. Mahanty</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00C295 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00C295 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:7501419
|texte= Immunoregulation in human lymphatic filariasis: the role of interleukin 10.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:7501419" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |