Cutaneous vascular control in the arms of women with postmastectomy oedema.
Identifieur interne : 00BD35 ( Main/Exploration ); précédent : 00BD34; suivant : 00BD36Cutaneous vascular control in the arms of women with postmastectomy oedema.
Auteurs : A W Stanton [Royaume-Uni] ; J R Levick ; Peter Mortimer (dermatologue) [Royaume-Uni]Source :
- Experimental physiology [ 0958-0670 ] ; 1996.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Mastectomie.
- physiopathologie : Hyperhémie, Oedème.
- étiologie : Oedème.
- Adulte d'âge moyen, Basse température, Bras, Femelle, Humains, Peau, Résistance vasculaire, Sujet âgé, Température élevée, Vasoconstriction, Vasodilatation.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Mastectomy.
- blood supply : Arm, Skin.
- drug effects : Vasoconstriction, Vasodilation.
- etiology : Edema.
- physiopathology : Edema, Hyperemia.
- Aged, Cold Temperature, Female, Hot Temperature, Humans, Middle Aged, Vascular Resistance.
Abstract
The control of forearm skin blood flow was examined in the swollen arms of twelve women with oedema caused by breast cancer treatment. The swollen arm was compared with the opposite unaffected (control) arm. Using laser Doppler flux (LDF) and continuous finger blood pressure (BP) measurements, vascular control was tested by applying a range of provocations previously shown to alter cutaneous vascular resistance (CVR) in healthy subjects. The tests and the accepted mechanism were: post-ischaemic hyperaemia (locally mediated vasodilatation), inspiratory gasp and cool reflex (both sympathetically mediated vasoconstriction), arm dependency (locally mediated vasoconstriction), and core heat load (sympathetically mediated vasodilatation). CVR was calculated as BP/(LDF-biological zero). Three differences between the control and swollen arms were identified. (i) The laser Doppler biological zero signal was significantly higher on the swollen side (P = 0.005, Student's paired t test). (ii) Baseline LDF was significantly lower on the swollen side (P = 0.002), and apparent CVR correspondingly higher. (iii) Cumulative reactive hyperaemia (area under the LDF curve above baseline) was significantly less on the swollen side (P = 0.03), although peak flux was not significantly different. Inspiratory gasp, cool reflex, arm dependency and core heat load produced changes of similar magnitude in both arms. It appears that sympathetic neural control and local vasoconstrictor control in arm dependency are normal in arm lymphoedema but that locally mediated vasodilator control is impaired. In addition, baseline skin blood flow may be reduced in this condition. The results provide no support for impairment of vascular tone as a contributory factor to the oedematous state.
PubMed: 8737078
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 005182
- to stream PubMed, to step Curation: 005182
- to stream PubMed, to step Checkpoint: 005182
- to stream Ncbi, to step Merge: 00B761
- to stream Ncbi, to step Curation: 00B761
- to stream Ncbi, to step Checkpoint: 00B761
- to stream Main, to step Merge: 00C576
- to stream Main, to step Curation: 00BD35
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cutaneous vascular control in the arms of women with postmastectomy oedema.</title>
<author><name sortKey="Stanton, A W" sort="Stanton, A W" uniqKey="Stanton A" first="A W" last="Stanton">A W Stanton</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medicine (Physiological Division), St George's Hospital Medical School, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Medicine (Physiological Division), St George's Hospital Medical School, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name>
</author>
<author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name>
<affiliation><country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1996">1996</date>
<idno type="RBID">pubmed:8737078</idno>
<idno type="pmid">8737078</idno>
<idno type="wicri:Area/PubMed/Corpus">005182</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005182</idno>
<idno type="wicri:Area/PubMed/Curation">005182</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005182</idno>
<idno type="wicri:Area/PubMed/Checkpoint">005182</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005182</idno>
<idno type="wicri:Area/Ncbi/Merge">00B761</idno>
<idno type="wicri:Area/Ncbi/Curation">00B761</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">00B761</idno>
<idno type="wicri:doubleKey">0958-0670:1996:Stanton A:cutaneous:vascular:control</idno>
<idno type="wicri:Area/Main/Merge">00C576</idno>
<idno type="wicri:Area/Main/Curation">00BD35</idno>
<idno type="wicri:Area/Main/Exploration">00BD35</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Cutaneous vascular control in the arms of women with postmastectomy oedema.</title>
<author><name sortKey="Stanton, A W" sort="Stanton, A W" uniqKey="Stanton A" first="A W" last="Stanton">A W Stanton</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medicine (Physiological Division), St George's Hospital Medical School, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Medicine (Physiological Division), St George's Hospital Medical School, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name>
</author>
<author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name>
<affiliation><country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Experimental physiology</title>
<idno type="ISSN">0958-0670</idno>
<imprint><date when="1996" type="published">1996</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Arm (blood supply)</term>
<term>Cold Temperature</term>
<term>Edema (etiology)</term>
<term>Edema (physiopathology)</term>
<term>Female</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Hyperemia (physiopathology)</term>
<term>Mastectomy (adverse effects)</term>
<term>Middle Aged</term>
<term>Skin (blood supply)</term>
<term>Vascular Resistance</term>
<term>Vasoconstriction (drug effects)</term>
<term>Vasodilation (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Basse température</term>
<term>Bras ()</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hyperhémie (physiopathologie)</term>
<term>Mastectomie (effets indésirables)</term>
<term>Oedème (physiopathologie)</term>
<term>Oedème (étiologie)</term>
<term>Peau ()</term>
<term>Résistance vasculaire</term>
<term>Sujet âgé</term>
<term>Température élevée</term>
<term>Vasoconstriction ()</term>
<term>Vasodilatation ()</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Arm</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Vasoconstriction</term>
<term>Vasodilation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Edema</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hyperhémie</term>
<term>Oedème</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Edema</term>
<term>Hyperemia</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Oedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cold Temperature</term>
<term>Female</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Vascular Resistance</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Basse température</term>
<term>Bras</term>
<term>Femelle</term>
<term>Humains</term>
<term>Peau</term>
<term>Résistance vasculaire</term>
<term>Sujet âgé</term>
<term>Température élevée</term>
<term>Vasoconstriction</term>
<term>Vasodilatation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The control of forearm skin blood flow was examined in the swollen arms of twelve women with oedema caused by breast cancer treatment. The swollen arm was compared with the opposite unaffected (control) arm. Using laser Doppler flux (LDF) and continuous finger blood pressure (BP) measurements, vascular control was tested by applying a range of provocations previously shown to alter cutaneous vascular resistance (CVR) in healthy subjects. The tests and the accepted mechanism were: post-ischaemic hyperaemia (locally mediated vasodilatation), inspiratory gasp and cool reflex (both sympathetically mediated vasoconstriction), arm dependency (locally mediated vasoconstriction), and core heat load (sympathetically mediated vasodilatation). CVR was calculated as BP/(LDF-biological zero). Three differences between the control and swollen arms were identified. (i) The laser Doppler biological zero signal was significantly higher on the swollen side (P = 0.005, Student's paired t test). (ii) Baseline LDF was significantly lower on the swollen side (P = 0.002), and apparent CVR correspondingly higher. (iii) Cumulative reactive hyperaemia (area under the LDF curve above baseline) was significantly less on the swollen side (P = 0.03), although peak flux was not significantly different. Inspiratory gasp, cool reflex, arm dependency and core heat load produced changes of similar magnitude in both arms. It appears that sympathetic neural control and local vasoconstrictor control in arm dependency are normal in arm lymphoedema but that locally mediated vasodilator control is impaired. In addition, baseline skin blood flow may be reduced in this condition. The results provide no support for impairment of vascular tone as a contributory factor to the oedematous state.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
<orgName><li>Université de Londres</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name>
</noCountry>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Stanton, A W" sort="Stanton, A W" uniqKey="Stanton A" first="A W" last="Stanton">A W Stanton</name>
</region>
<name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00BD35 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00BD35 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:8737078 |texte= Cutaneous vascular control in the arms of women with postmastectomy oedema. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8737078" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |