The LYMFASIM simulation program for modeling lymphatic filariasis and its control.
Identifieur interne : 00B053 ( Main/Exploration ); précédent : 00B052; suivant : 00B054The LYMFASIM simulation program for modeling lymphatic filariasis and its control.
Auteurs : A P Plaisier [Pays-Bas] ; S. Subramanian ; P K Das ; W. Souza ; T. Lapa ; A F Furtado ; C P Van Der Ploeg ; J D Habbema ; G J Van OortmarssenSource :
- Methods of information in medicine [ 0026-1270 ] ; 1998.
Descripteurs français
- KwdFr :
- Adolescent, Animaux, Brésil, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (), Filariose lymphatique (parasitologie), Filariose lymphatique (physiopathologie), Filariose lymphatique (épidémiologie), Humains, Modèles biologiques, Mâle, Nourrisson, Nouveau-né, Prise de décision assistée par ordinateur, Simulation numérique, Wuchereria bancrofti (physiologie).
- MESH :
- parasitologie : Filariose lymphatique.
- physiologie : Wuchereria bancrofti.
- physiopathologie : Filariose lymphatique.
- épidémiologie : Filariose lymphatique.
- Adolescent, Animaux, Brésil, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Humains, Modèles biologiques, Mâle, Nourrisson, Nouveau-né, Prise de décision assistée par ordinateur, Simulation numérique.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- Adolescent, Animals, Brazil, Child, Child, Preschool, Computer Simulation, Decision Making, Computer-Assisted, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (physiopathology), Elephantiasis, Filarial (prevention & control), Female, Humans, Infant, Infant, Newborn, Male, Models, Biological, Wuchereria bancrofti (physiology).
- MESH :
- geographic : Brazil.
- epidemiology : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- physiology : Wuchereria bancrofti.
- physiopathology : Elephantiasis, Filarial.
- prevention & control : Elephantiasis, Filarial.
- Adolescent, Animals, Child, Child, Preschool, Computer Simulation, Decision Making, Computer-Assisted, Female, Humans, Infant, Infant, Newborn, Male, Models, Biological.
Abstract
The LYMFASIM modeling framework for the transmission and control of the tropical parasitic disease lymphatic filariasis is described and its use in the context of an endemic community in north-eastern Brazil is illustrated. Lymphatic filariasis is a disease with a complex natural history with many unknowns. This complicates decision making with respect to control strategies. With LYMFASIM, a variety of hypotheses can be tested about the life history of the parasite Wuchereria bancrofti, its transmission from man to man through mosquitoes, the role of the immune system in regulating parasite numbers, the development of disease symptoms, and the effects of control measures (drug treatment or mosquito control). The implications of alternative assumptions and uncertainty about the quantification of parameters for the effectiveness of control strategies can be investigated. Thanks to the use of stochastic microsimulation, LYMFASIM is highly flexible and can be adapted and extended as new knowledge emerges.
PubMed: 9550853
Affiliations:
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<front><div type="abstract" xml:lang="en">The LYMFASIM modeling framework for the transmission and control of the tropical parasitic disease lymphatic filariasis is described and its use in the context of an endemic community in north-eastern Brazil is illustrated. Lymphatic filariasis is a disease with a complex natural history with many unknowns. This complicates decision making with respect to control strategies. With LYMFASIM, a variety of hypotheses can be tested about the life history of the parasite Wuchereria bancrofti, its transmission from man to man through mosquitoes, the role of the immune system in regulating parasite numbers, the development of disease symptoms, and the effects of control measures (drug treatment or mosquito control). The implications of alternative assumptions and uncertainty about the quantification of parameters for the effectiveness of control strategies can be investigated. Thanks to the use of stochastic microsimulation, LYMFASIM is highly flexible and can be adapted and extended as new knowledge emerges.</div>
</front>
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