Effectiveness of annual ivermectin treatment for Wuchereria bancrofti infection.
Identifieur interne : 00A260 ( Main/Exploration ); précédent : 00A259; suivant : 00A261Effectiveness of annual ivermectin treatment for Wuchereria bancrofti infection.
Auteurs : A P Plaisier [Pays-Bas] ; W A Stolk ; G J Van Oortmarssen ; J D HabbemaSource :
- Parasitology today (Personal ed.) [ 0169-4758 ] ; 2000.
Descripteurs français
- KwdFr :
- MESH :
- parasitologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Filaricides, Ivermectine.
- Animaux, Humains, Modèles biologiques, Résultat thérapeutique, Wuchereria bancrofti.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Filaricides, Ivermectin.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- Animals, Humans, Models, Biological, Treatment Outcome, Wuchereria bancrofti.
Abstract
Using estimates for the anthelmintic efficacy of a single dose of ivermectin in the treatment of lymphatic filariasis patients, Anton Plaisier, Wilma Stolk, Gerrit van Oortmarssen and Dik Habbema here present and discuss model predictions of the impact of a five-year programme of annual community treatment on the intensity of infection. They show that the effectiveness of such programmes in terms of reductions in the microfilarial density depends critically on the treatment coverage and the pattern of attendance at repeated mass administrations. Improving these factors will possibly be more important than improving the efficacy of ivermectin by increasing its dosage or by adding other drugs.
PubMed: 10858649
Affiliations:
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Le document en format XML
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Oortmarssen, G J" sort="Van Oortmarssen, G J" uniqKey="Van Oortmarssen G" first="G J" last="Van Oortmarssen">G J Van Oortmarssen</name></author><author><name sortKey="Habbema, J D" sort="Habbema, J D" uniqKey="Habbema J" first="J D" last="Habbema">J D Habbema</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10858649</idno><idno type="pmid">10858649</idno><idno type="wicri:Area/PubMed/Corpus">004A57</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004A57</idno><idno type="wicri:Area/PubMed/Curation">004A57</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004A57</idno><idno type="wicri:Area/PubMed/Checkpoint">004A57</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004A57</idno><idno type="wicri:Area/Ncbi/Merge">000354</idno><idno type="wicri:Area/Ncbi/Curation">000354</idno><idno 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Rotterdam, PO Box 1738, 3000 DR Rotterdam</wicri:regionArea><wicri:noRegion>3000 DR Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Stolk, W A" sort="Stolk, W A" uniqKey="Stolk W" first="W A" last="Stolk">W A Stolk</name></author><author><name sortKey="Van Oortmarssen, G J" sort="Van Oortmarssen, G J" uniqKey="Van Oortmarssen G" first="G J" last="Van Oortmarssen">G J Van Oortmarssen</name></author><author><name sortKey="Habbema, J D" sort="Habbema, J D" uniqKey="Habbema J" first="J D" last="Habbema">J D Habbema</name></author></analytic><series><title level="j">Parasitology today (Personal ed.)</title><idno type="ISSN">0169-4758</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Ivermectin (therapeutic use)</term><term>Models, Biological</term><term>Treatment Outcome</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Ivermectine (usage thérapeutique)</term><term>Modèles biologiques</term><term>Résultat thérapeutique</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Filaricides</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Biological</term><term>Treatment Outcome</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Modèles biologiques</term><term>Résultat thérapeutique</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using estimates for the anthelmintic efficacy of a single dose of ivermectin in the treatment of lymphatic filariasis patients, Anton Plaisier, Wilma Stolk, Gerrit van Oortmarssen and Dik Habbema here present and discuss model predictions of the impact of a five-year programme of annual community treatment on the intensity of infection. They show that the effectiveness of such programmes in terms of reductions in the microfilarial density depends critically on the treatment coverage and the pattern of attendance at repeated mass administrations. Improving these factors will possibly be more important than improving the efficacy of ivermectin by increasing its dosage or by adding other drugs.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Habbema, J D" sort="Habbema, J D" uniqKey="Habbema J" first="J D" last="Habbema">J D Habbema</name><name sortKey="Stolk, W A" sort="Stolk, W A" uniqKey="Stolk W" first="W A" last="Stolk">W A Stolk</name><name sortKey="Van Oortmarssen, G J" sort="Van Oortmarssen, G J" uniqKey="Van Oortmarssen G" first="G J" last="Van Oortmarssen">G J Van Oortmarssen</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Plaisier, A P" sort="Plaisier, A P" uniqKey="Plaisier A" first="A P" last="Plaisier">A P Plaisier</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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