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Prädiktoren des Armlymphödems beim frühen Mammakarzinom

Identifieur interne : 009907 ( Main/Exploration ); précédent : 009906; suivant : 009908

Prädiktoren des Armlymphödems beim frühen Mammakarzinom

Auteurs : M. K. Fehr [Suisse] ; M. Erismann [Suisse] ; Ch. Schneider [Suisse] ; U. Haller [Suisse] ; D. Fink [Suisse]

Source :

RBID : Pascal:02-0534728

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English descriptors

Abstract

Purpose: Lymphedema of the arm develops in 6% to 30% of women undergoing axillary lymph node dissection for early breast cancer. We aimed to identify preoperative factors associated with lymphedema. Patients and Methods: We reviewed the records of 411 consecutive women with early breast cancer who underwent dissection of axillary levels I and II (n = 127) or I, II and III (n = 284) between 1992 and 1998. Cases of lymphedema necessitating treatment were identified. The mean follow-up was 45 ± 17 months. Results: Overall 21.6% of women underwent treatment for lymphedema. Univariate predictors of lymphedema were high body mass index (BMI), young age, premenopausal status (33% vs. 18%), poor tumor differentiation, dissection of level III (25% vs.15%), and adjuvant chemotherapy (29% vs. 19%). In the multivariate analysis high BMI (P=0.005) and premenopausal status (P = 0.0002) remained predictors of lymphedema. Conclusion: Premenopausal status and obesity are independent risk factors for the development of upper extremity lymphedema after axillary lymph node dissection. These patients may benefit most from sentinel lymphadenectomy.


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Le document en format XML

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<term>Dissection</term>
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<term>Tumeur maligne</term>
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<div type="abstract" xml:lang="en">Purpose: Lymphedema of the arm develops in 6% to 30% of women undergoing axillary lymph node dissection for early breast cancer. We aimed to identify preoperative factors associated with lymphedema. Patients and Methods: We reviewed the records of 411 consecutive women with early breast cancer who underwent dissection of axillary levels I and II (n = 127) or I, II and III (n = 284) between 1992 and 1998. Cases of lymphedema necessitating treatment were identified. The mean follow-up was 45 ± 17 months. Results: Overall 21.6% of women underwent treatment for lymphedema. Univariate predictors of lymphedema were high body mass index (BMI), young age, premenopausal status (33% vs. 18%), poor tumor differentiation, dissection of level III (25% vs.15%), and adjuvant chemotherapy (29% vs. 19%). In the multivariate analysis high BMI (P=0.005) and premenopausal status (P = 0.0002) remained predictors of lymphedema. Conclusion: Premenopausal status and obesity are independent risk factors for the development of upper extremity lymphedema after axillary lymph node dissection. These patients may benefit most from sentinel lymphadenectomy.</div>
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