Prädiktoren des Armlymphödems beim frühen Mammakarzinom
Identifieur interne : 009907 ( Main/Exploration ); précédent : 009906; suivant : 009908Prädiktoren des Armlymphödems beim frühen Mammakarzinom
Auteurs : M. K. Fehr [Suisse] ; M. Erismann [Suisse] ; Ch. Schneider [Suisse] ; U. Haller [Suisse] ; D. Fink [Suisse]Source :
- Geburtshilfe und Frauenheilkunde [ 0016-5751 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte, Personne âgée.
English descriptors
- KwdEn :
Abstract
Purpose: Lymphedema of the arm develops in 6% to 30% of women undergoing axillary lymph node dissection for early breast cancer. We aimed to identify preoperative factors associated with lymphedema. Patients and Methods: We reviewed the records of 411 consecutive women with early breast cancer who underwent dissection of axillary levels I and II (n = 127) or I, II and III (n = 284) between 1992 and 1998. Cases of lymphedema necessitating treatment were identified. The mean follow-up was 45 ± 17 months. Results: Overall 21.6% of women underwent treatment for lymphedema. Univariate predictors of lymphedema were high body mass index (BMI), young age, premenopausal status (33% vs. 18%), poor tumor differentiation, dissection of level III (25% vs.15%), and adjuvant chemotherapy (29% vs. 19%). In the multivariate analysis high BMI (P=0.005) and premenopausal status (P = 0.0002) remained predictors of lymphedema. Conclusion: Premenopausal status and obesity are independent risk factors for the development of upper extremity lymphedema after axillary lymph node dissection. These patients may benefit most from sentinel lymphadenectomy.
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age</term>
<term>Axillary ganglion</term>
<term>Body mass index</term>
<term>Breast</term>
<term>Complication</term>
<term>Dissection</term>
<term>Elderly</term>
<term>Female</term>
<term>Iatrogenic</term>
<term>Lymphedema</term>
<term>Malignant tumor</term>
<term>Predictive factor</term>
<term>Preoperative</term>
<term>Risk factor</term>
<term>Sexually active period</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tumeur maligne</term>
<term>Sein</term>
<term>Dissection</term>
<term>Ganglion axillaire</term>
<term>Complication</term>
<term>Iatrogène</term>
<term>Facteur prédictif</term>
<term>Préopératoire</term>
<term>Lymphoedème</term>
<term>Facteur risque</term>
<term>Indice masse corporelle</term>
<term>Age</term>
<term>Période activité génitale</term>
<term>Adulte</term>
<term>Personne âgée</term>
<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">Purpose: Lymphedema of the arm develops in 6% to 30% of women undergoing axillary lymph node dissection for early breast cancer. We aimed to identify preoperative factors associated with lymphedema. Patients and Methods: We reviewed the records of 411 consecutive women with early breast cancer who underwent dissection of axillary levels I and II (n = 127) or I, II and III (n = 284) between 1992 and 1998. Cases of lymphedema necessitating treatment were identified. The mean follow-up was 45 ± 17 months. Results: Overall 21.6% of women underwent treatment for lymphedema. Univariate predictors of lymphedema were high body mass index (BMI), young age, premenopausal status (33% vs. 18%), poor tumor differentiation, dissection of level III (25% vs.15%), and adjuvant chemotherapy (29% vs. 19%). In the multivariate analysis high BMI (P=0.005) and premenopausal status (P = 0.0002) remained predictors of lymphedema. Conclusion: Premenopausal status and obesity are independent risk factors for the development of upper extremity lymphedema after axillary lymph node dissection. These patients may benefit most from sentinel lymphadenectomy.</div>
</front>
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