Dermatologic manifestations of Crohn disease in children: Response to infliximab
Identifieur interne : 009272 ( Main/Exploration ); précédent : 009271; suivant : 009273Dermatologic manifestations of Crohn disease in children: Response to infliximab
Auteurs : Subra Kugathasan [États-Unis] ; Adrian Miranda [États-Unis] ; James Nocton [États-Unis] ; Beth A. Drolet [États-Unis] ; Carolyn Raasch [États-Unis] ; David G. Binion [États-Unis]Source :
- Journal of pediatric gastroenterology and nutrition [ 0277-2116 ] ; 2003.
Descripteurs français
- KwdFr :
- Adolescent, Anticorps monoclonaux (effets indésirables), Anticorps monoclonaux (usage thérapeutique), Enfant, Humains, Infliximab, Lymphoedème (traitement médicamenteux), Lymphoedème (étiologie), Maladie de Crohn (), Mâle, Produits dermatologiques (effets indésirables), Produits dermatologiques (usage thérapeutique), Pyodermie phadégénique (traitement médicamenteux), Pyodermie phadégénique (étiologie), Résultat thérapeutique, Érythème noueux (traitement médicamenteux), Érythème noueux (étiologie).
- MESH :
- effets indésirables : Anticorps monoclonaux, Produits dermatologiques.
- traitement médicamenteux : Lymphoedème, Pyodermie phadégénique, Érythème noueux.
- usage thérapeutique : Anticorps monoclonaux, Produits dermatologiques.
- étiologie : Lymphoedème, Pyodermie phadégénique, Érythème noueux.
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
- Adolescent, Antibodies, Monoclonal (adverse effects), Antibodies, Monoclonal (therapeutic use), Anticytokine, Case study, Chemotherapy, Child, Complication, Crohn Disease (complications), Crohn disease, Dermatologic Agents (adverse effects), Dermatologic Agents (therapeutic use), Erythema Nodosum (drug therapy), Erythema Nodosum (etiology), Erythema nodosum, Humans, Infliximab, Lymphedema, Lymphedema (drug therapy), Lymphedema (etiology), Male, Pyoderma Gangrenosum (drug therapy), Pyoderma Gangrenosum (etiology), Pyoderma gangrenosum, Treatment Outcome, Treatment efficiency.
- MESH :
- chemical , adverse effects : Antibodies, Monoclonal, Dermatologic Agents.
- chemical , therapeutic use : Antibodies, Monoclonal, Dermatologic Agents.
- complications : Crohn Disease.
- drug therapy : Erythema Nodosum, Lymphedema, Pyoderma Gangrenosum.
- etiology : Erythema Nodosum, Lymphedema, Pyoderma Gangrenosum.
- Adolescent, Child, Humans, Infliximab, Male, Treatment Outcome.
Abstract
Dermatologic extraintestinal manifestations of Crohn disease may be refractory to treatment with corticosteroids and immunomodulators. The authors describe four children with Crohn disease with dermatologic manifestations: pyoderma gangrenosum, orofacial involvement, erythema nodosum, and idiopathic lymphedema. These dermatologic conditions were unresponsive to conventional therapy but had rapid and sustained response to the anti-TNF-α antibody infliximab. No adverse reactions occurred. Infliximab should be considered for treating the extraintestinal dermatologic manifestations of Crohn disease in children.
Affiliations:
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Binion</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin</s1><s2>Milwaukee, Wisconsin</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of pediatric gastroenterology and nutrition</title><title level="j" type="abbreviated">J. pediatr. gastroenterol. nutr.</title><idno type="ISSN">0277-2116</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of pediatric gastroenterology and nutrition</title><title level="j" type="abbreviated">J. pediatr. gastroenterol. nutr.</title><idno type="ISSN">0277-2116</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Antibodies, Monoclonal (adverse effects)</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Anticytokine</term><term>Case study</term><term>Chemotherapy</term><term>Child</term><term>Complication</term><term>Crohn Disease (complications)</term><term>Crohn disease</term><term>Dermatologic Agents (adverse effects)</term><term>Dermatologic Agents (therapeutic use)</term><term>Erythema Nodosum (drug therapy)</term><term>Erythema Nodosum (etiology)</term><term>Erythema nodosum</term><term>Humans</term><term>Infliximab</term><term>Lymphedema</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (etiology)</term><term>Male</term><term>Pyoderma Gangrenosum (drug therapy)</term><term>Pyoderma Gangrenosum (etiology)</term><term>Pyoderma gangrenosum</term><term>Treatment Outcome</term><term>Treatment efficiency</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Anticorps monoclonaux (effets indésirables)</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Enfant</term><term>Humains</term><term>Infliximab</term><term>Lymphoedème (traitement médicamenteux)</term><term>Lymphoedème (étiologie)</term><term>Maladie de Crohn ()</term><term>Mâle</term><term>Produits dermatologiques (effets indésirables)</term><term>Produits dermatologiques (usage thérapeutique)</term><term>Pyodermie phadégénique (traitement médicamenteux)</term><term>Pyodermie phadégénique (étiologie)</term><term>Résultat thérapeutique</term><term>Érythème noueux (traitement médicamenteux)</term><term>Érythème noueux (étiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Dermatologic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Dermatologic Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Crohn Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Erythema Nodosum</term><term>Lymphedema</term><term>Pyoderma Gangrenosum</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Produits dermatologiques</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Erythema Nodosum</term><term>Lymphedema</term><term>Pyoderma Gangrenosum</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term><term>Pyodermie phadégénique</term><term>Érythème noueux</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Produits dermatologiques</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term><term>Pyodermie phadégénique</term><term>Érythème noueux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Humans</term><term>Infliximab</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Entérite Crohn</term><term>Complication</term><term>Humains</term><term>Infliximab</term><term>Maladie de Crohn</term><term>Mâle</term><term>Pyodermite phagédénique</term><term>Erythème noueux</term><term>Lymphoedème</term><term>Efficacité traitement</term><term>Chimiothérapie</term><term>Infliximab</term><term>Anticytokine</term><term>Etude cas</term><term>Enfant</term><term>Résultat thérapeutique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dermatologic extraintestinal manifestations of Crohn disease may be refractory to treatment with corticosteroids and immunomodulators. The authors describe four children with Crohn disease with dermatologic manifestations: pyoderma gangrenosum, orofacial involvement, erythema nodosum, and idiopathic lymphedema. These dermatologic conditions were unresponsive to conventional therapy but had rapid and sustained response to the anti-TNF-α antibody infliximab. No adverse reactions occurred. Infliximab should be considered for treating the extraintestinal dermatologic manifestations of Crohn disease in children.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Kugathasan, Subra" sort="Kugathasan, Subra" uniqKey="Kugathasan S" first="Subra" last="Kugathasan">Subra Kugathasan</name></region><name sortKey="Binion, David G" sort="Binion, David G" uniqKey="Binion D" first="David G." last="Binion">David G. Binion</name><name sortKey="Drolet, Beth A" sort="Drolet, Beth A" uniqKey="Drolet B" first="Beth A." last="Drolet">Beth A. Drolet</name><name sortKey="Miranda, Adrian" sort="Miranda, Adrian" uniqKey="Miranda A" first="Adrian" last="Miranda">Adrian Miranda</name><name sortKey="Nocton, James" sort="Nocton, James" uniqKey="Nocton J" first="James" last="Nocton">James Nocton</name><name sortKey="Raasch, Carolyn" sort="Raasch, Carolyn" uniqKey="Raasch C" first="Carolyn" last="Raasch">Carolyn Raasch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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