Factors influencing arm and axillary symptoms after treatment for node negative breast carcinoma
Identifieur interne : 009267 ( Main/Exploration ); précédent : 009266; suivant : 009268Factors influencing arm and axillary symptoms after treatment for node negative breast carcinoma
Auteurs : Karen P. L. Yap [Canada] ; David R. Mccready [Canada] ; Steven Narod [Canada] ; Lee A. Manchul [Canada] ; Maureen Trudeau [Canada] ; Anthony Fyles [Canada]Source :
- Cancer [ 0008-543X ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
BACKGROUND. The purpose of the current study was to identify the factors that contribute to postoperative arm symptoms following breast conserving surgery in a well-defined cohort of node negative breast carcinoma patients. METHODS. A convenience sample of 370 women ≥ 50 years of age with node negative breast carcinoma who were participants in a randomized controlled trial designed to assess the need for breast radiation in addition to tamoxifen were surveyed. Axillary dissection was optional for patients 65 years or older and who were clinically node negative. RESULTS. A total of 65.1%(241/370) of women had ipsilateral shoulder or arm symptoms. Multivariate analysis revealed that axillary dissection, breast radiation, and younger age (odds ratio = 11.2, 1.65, and 3.8 respectively) were significantly (P < 0.05) associated with increased ipsilateral shoulder or arm symptoms. Treatment with axillary dissection and breast radiation were significant factors (P <0.02) associated with the self-reporting of arm swelling (odds ratio = 4.4 and 2.0, respectively). Patients 70 years old or greater reported significantly fewer arm symptoms (odds ratio = 0.26, P < 0.05) after axillary dissection. CONCLUSIONS. Arm symptoms were present in about 80% of patients who underwent breast conserving surgery, axillary dissection, and breast radiation in the current study These symptoms were significantly associated with the use of axillary dissection, breast radiation, and younger age. Older patients experienced fewer arm symptoms after standard treatment for node negative breast carcinoma, and thus older age should not be a contraindication to axillary dissection.
Affiliations:
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Mccready</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre of Research in Women's Health, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Manchul, Lee A" sort="Manchul, Lee A" uniqKey="Manchul L" first="Lee A." last="Manchul">Lee A. 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L." last="Yap">Karen P. L. Yap</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Mccready, David R" sort="Mccready, David R" uniqKey="Mccready D" first="David R." last="Mccready">David R. Mccready</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre of Research in Women's Health, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Manchul, Lee A" sort="Manchul, Lee A" uniqKey="Manchul L" first="Lee A." last="Manchul">Lee A. Manchul</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Trudeau, Maureen" sort="Trudeau, Maureen" uniqKey="Trudeau M" first="Maureen" last="Trudeau">Maureen Trudeau</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Medical Oncology, Sunnybrook & Women's College Health Sciences Centre, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Fyles, Anthony" sort="Fyles, Anthony" uniqKey="Fyles A" first="Anthony" last="Fyles">Anthony Fyles</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Cancer</title><title level="j" type="abbreviated">Cancer</title><idno type="ISSN">0008-543X</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Cancer</title><title level="j" type="abbreviated">Cancer</title><idno type="ISSN">0008-543X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term><term>Carcinoma</term><term>Complication</term><term>Conservative surgery</term><term>Early stage</term><term>Human</term><term>Lymphadenectomy</term><term>Lymphedema</term><term>Mammary gland</term><term>Motility disorder</term><term>Radiotherapy</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Carcinome</term><term>Glande mammaire</term><term>Stade précoce</term><term>Lymphadénectomie</term><term>Chirurgie conservatrice</term><term>Radiothérapie</term><term>Lymphoedème</term><term>Bras</term><term>Traitement</term><term>Trouble motricité</term><term>Complication</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND. The purpose of the current study was to identify the factors that contribute to postoperative arm symptoms following breast conserving surgery in a well-defined cohort of node negative breast carcinoma patients. METHODS. A convenience sample of 370 women ≥ 50 years of age with node negative breast carcinoma who were participants in a randomized controlled trial designed to assess the need for breast radiation in addition to tamoxifen were surveyed. Axillary dissection was optional for patients 65 years or older and who were clinically node negative. RESULTS. A total of 65.1%(241/370) of women had ipsilateral shoulder or arm symptoms. Multivariate analysis revealed that axillary dissection, breast radiation, and younger age (odds ratio = 11.2, 1.65, and 3.8 respectively) were significantly (P < 0.05) associated with increased ipsilateral shoulder or arm symptoms. Treatment with axillary dissection and breast radiation were significant factors (P <0.02) associated with the self-reporting of arm swelling (odds ratio = 4.4 and 2.0, respectively). Patients 70 years old or greater reported significantly fewer arm symptoms (odds ratio = 0.26, P < 0.05) after axillary dissection. CONCLUSIONS. Arm symptoms were present in about 80% of patients who underwent breast conserving surgery, axillary dissection, and breast radiation in the current study These symptoms were significantly associated with the use of axillary dissection, breast radiation, and younger age. Older patients experienced fewer arm symptoms after standard treatment for node negative breast carcinoma, and thus older age should not be a contraindication to axillary dissection.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Yap, Karen P L" sort="Yap, Karen P L" uniqKey="Yap K" first="Karen P. L." last="Yap">Karen P. L. Yap</name></region><name sortKey="Fyles, Anthony" sort="Fyles, Anthony" uniqKey="Fyles A" first="Anthony" last="Fyles">Anthony Fyles</name><name sortKey="Manchul, Lee A" sort="Manchul, Lee A" uniqKey="Manchul L" first="Lee A." last="Manchul">Lee A. Manchul</name><name sortKey="Mccready, David R" sort="Mccready, David R" uniqKey="Mccready D" first="David R." last="Mccready">David R. Mccready</name><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name><name sortKey="Trudeau, Maureen" sort="Trudeau, Maureen" uniqKey="Trudeau M" first="Maureen" last="Trudeau">Maureen Trudeau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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